Review
Oncology
Pinaki Mondal, Katie L. Bailey, Sara B. Cartwright, Vimla Band, Mark A. Carlson
Summary: This mini review discusses the current status, advantages, and disadvantages of large animal modeling of breast cancer (BC). Recently, there has been interest in developing porcine BC models, which show promising results for mimicking human disease. The widely used rodent models of BC are also briefly reviewed. The availability of large animal BC models could provide additional tools for BC research and models with greater biological relevance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Natasha N. Knier, Sierra Pellizzari, Jiangbing Zhou, Paula J. Foster, Armen Parsyan
Summary: Breast cancer brain metastases (BCBM) are a major cause of female mortality worldwide. The scarcity of representative experimental preclinical models has hindered the advancement of BCBM treatment. However, recent developments in patient-derived in vitro and in vivo breast cancer culturing systems, along with advances in animal brain imaging, have provided opportunities to better understand BCBM biology and develop novel treatment approaches.
Review
Biochemistry & Molecular Biology
Marina A. Ryazanova, Vladislava S. Plekanchuk, Olga I. Prokudina, Yulia V. Makovka, Tatiana A. Alekhina, Olga E. Redina, Arcady L. Markel
Summary: Research on the genetic and physiological mechanisms of widespread disorders is important in academic and practical medicine and biology. Animal models are used to overcome limitations and difficulties in such studies. Different approaches, including genetic technologies and breeding, have been used to create animal models of human pathologies. This review describes three rat models developed through breeding in a research institute.
Article
Clinical Neurology
Thais Helena Figueiredo do Bonfim, Renata Leite Tavares, Maria Helena Araujo de Vasconcelos, Mirela Gouveia, Polyana Campos Nunes, Nais Lira Soares, Raquel Coutinho Alves, Jader Luciano Pinto de Carvalho, Adriano Francisco Alves, Ramon de Alencar Pereira, Glebia Alexa Cardoso, Alexandre Sergio Silva, Jailane de Souza Aquino
Summary: This study compared the effectiveness of western and cafeteria diets as obesity-inducing protocols, finding that the cafeteria diet was more effective in inducing obesity and causing a greater number of obesity-related metabolic and neurobehavioral disorders in the evaluated rats.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Pharmacology & Pharmacy
Paz Boix-Montesinos, Paula M. Soriano-Teruel, Ana Arminan, Mar Orzaez, Maria J. Vicent
Summary: Despite recent advancements in nanomedicine for breast cancer treatment and promising results in pre-clinical models, clinical trials often face challenges. Innovative cell culture strategies and consideration of critical parameters for in vivo evaluation are essential to improve the clinical translation efficiency of nanomedicines in breast cancer treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Chih-Chuan Yang, Mao-Hsien Wang, Hung-Sheng Soung, Hsiang-Chien Tseng, Feng-Huei Lin, Kuo-Chi Chang, Cheng-Chia Tsai
Summary: L-theanine, a major amino acid in green tea, has been found to alleviate Vincristine-induced peripheral neuropathy and associated neuronal functional changes in rats. The study showed that administration of L-theanine reduced pain sensitivity and nerve function loss caused by Vincristine, and it exhibited antioxidant, calcium-regulating, anti-inflammatory, anti-apoptotic, and neuroprotective properties.
Article
Cell Biology
Xin Jin, Janne Kaes, Jan Van Slambrouck, Ilhan Inci, Stephan Arni, Vincent Geudens, Tobias Heigl, Yanina Jansen, Marianne S. Carlon, Robin Vos, Dirk Van Raemdonck, Yi Zhang, Bart M. Vanaudenaerde, Laurens J. Ceulemans
Summary: Lung transplantation enhances the outcomes and quality of life for patients with end-stage pulmonary disease, though it still faces challenges due to limited suitable donors, complex surgery, and the potential for chronic lung allograft dysfunction. Small animal models, such as rats and mice, have been extensively used in immunology and pathobiology research for lung transplantation, offering advantages in terms of ethical considerations, cost-effectiveness, and high throughput possibilities.
Article
Biotechnology & Applied Microbiology
Baojun Fu, Rong Zhu
Summary: The mechanism of siSCN9A in Vincristine-induced neuropathic pain is still unclear. This study found that LV-siSCN9A infected neurons can play an analgesic role by down-regulating Nav1.7 expression induced by VCR in NP model.
Review
Oncology
George Sflomos, Koen Schipper, Thijs Koorman, Amanda Fitzpatrick, Steffi Oesterreich, Adrian V. Lee, Jos Jonkers, Valerie G. Brunton, Matthias Christgen, Clare Isacke, Patrick W. B. Derksen, Cathrin Brisken
Summary: Invasive lobular carcinoma (ILC) is the second most common histological subtype of invasive breast cancer, accounting for up to 15% of all cases. Despite responding well to endocrine treatment when estrogen receptor alpha-positive (ER+), it differs in biological aspects from other ER+ subtypes. Current advances in ILC modeling include cell lines, organotypic models, genetically engineered mouse models, and patient-derived xenografts, addressing critical challenges such as drug resistance, the tumor microenvironment, tumor dormancy, and metastasis. The European Lobular Breast Cancer Consortium (ELBCC) focuses on understanding and translating molecular cues underlying ILC to clinical diagnosis and intervention, providing essential considerations for researchers considering the implementation of ILC models.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiafan Ma, Kai Chen, Shunrong Li, Liling Zhu, Yunfang Yu, Jingwu Li, Jie Ma, Jie Ouyang, Zhuo Wu, Yujie Tan, Zifan He, Haiqing Liu, Zhilong Pan, Haojiang Li, Qiang Liu, Erwei Song
Summary: An MRI-based radiomic model was developed to predict the risk of margin positivity in breast-conserving surgery. The model can stratify patients into different risk subgroups and is associated with tumor immune-microenvironment alterations.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Li Zhang, Mingchao Li, Xiaochen Li, Taiyang Liao, Zhenyuan Ma, Zhang Li, Runlin Xing, Peimin Wang, Jun Mao
Summary: This study investigated the characteristics of sensory innervation in different KOA rat models and found a positive correlation between the degree of synovial fibrosis and the pain sensitivity of the KOA model rats. Surgical modeling, especially the ACLT method, is recommended for KOA pain research.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fernanda Elisa Ferreira Ananias, Victor Augusto Benedicto dos Santos, Francisco C. Groppo, Guilherme Elias Pessanha Henriques, Jose Roberto Toledo, Renata da Silva Pais, Sidney R. Figueroba
Summary: This study compared three models of inducing osteoarthritis (OA) and rheumatoid arthritis (RA) in the temporomandibular joint (TMJ) of rats. The results showed that injecting complete Freund's adjuvant (CFA) + type II bovine collagen (CII) into the TMJ induced OA, injecting CFA+CII into both the tail and TMJ induced RA+OA, and injecting CFA+CII only into the tail induced RA. After the injections, the thickness of the condylar cartilage and cytokine levels showed different changes in each group. Additionally, measuring cytokines to assess the severity of arthritis was feasible.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Oncology
Johnny Donovan, Zicheng Deng, Fenghua Bian, Samriddhi Shukla, Jose Gomez-Arroyo, Donglu Shi, Vladimir V. Kalinichenko, Tanya V. Kalin
Summary: Rhabdomyosarcoma (RMS) is a highly metastatic soft-tissue sarcoma that often develops resistance to current therapies. The combination treatment with specific FOXM1 inhibitor RCM1 and low doses of vincristine shows superior anti-tumor effects in vitro. Innovative nanoparticle delivery system NPFA efficiently delivers RCM1 to mouse RMS tumors and reduces tumor volumes in vivo. Knockdown of Chac1 recapitulates the effects of the combination therapy in vitro.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Angela N. Giaquinto, Hyuna Sung, Kimberly D. Miller, Joan L. Kramer, Lisa A. Newman, Adair Minihan, Ahmedin Jemal, Rebecca L. Siegel
Summary: This article provides an update on female breast cancer statistics in the United States, including data on incidence, mortality, survival, and mammography screening. It shows that breast cancer incidence rates have increased over the past few decades, driven by localized-stage and hormone receptor-positive disease. However, breast cancer mortality rates have been steadily declining since 1989, although at a slower pace in recent years. Despite lower incidence rates, there remains a racial disparity in breast cancer mortality, with higher rates among Black women compared to White women.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Oncology
You-Fan Zhao, Zhongwei Chen, Yang Zhang, Jiejie Zhou, Jeon-Hor Chen, Kyoung Eun Lee, Freddie J. Combs, Ritesh Parajuli, Rita S. Mehta, Meihao Wang, Min-Ying Su
Summary: By utilizing radiomics models built from features extracted from DCE-MRI and mammography, this study aimed to enhance the diagnostic accuracy of breast cancer. The combination of mammography features with MRI improved the specificity of the models, leading to decreased false positive diagnosis of contrast-enhanced benign lesions on MRI.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
D. M. B. Oliveira Souza, J. Genre, T. G. Alves Silva, C. P. Soares, K. Borges Ferreira Rocha, C. Nunes Oliveira, C. A. Nunes Jatoba, J. Marco de Leon Andrade, P. Moreau, A. da Cunha Medeiros, E. A. Donadi, J. C. de Oliveira Crispim
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Surgery
Aldo Cunha Medeiros, Alexandra Regia Dantas Brigido, Suyana Meneses Silva, Vanessa Ramalho Brito, Keyla Borges Ferreira Rocha, Claudia Nunes Oliveira
ACTA CIRURGICA BRASILEIRA
(2013)
Article
Surgery
Claudia Nunes Oliveira, Italo Medeiros Azevedo, Keyla Borges Ferreira Rocha, Eryvaldo Socrates Tabosa Egito, Aldo Cunha Medeiros
Summary: This study found that in a rat model, ileum and colon resection have different effects on liver regeneration. Colon resection has a positive influence on liver regeneration, while ileum resection negatively impacts the regenerative process.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Medicine, Research & Experimental
Joquebede Rodrigues Pereira, Aldilane Goncalves da Fonseca, Luzia Leiros de Sena Fernandes, Allanny Alves Furtado, Valeria Costa da Silva, Valdir Florencio da Veiga Junior, Antonio Euzebio Goulart Sant'Ana, Claudia Nunes Oliveira, Gerlane Coelho Bernardo Guerra, Matheus De Freitas Fernandes-Pedrosa, Elaine Cristina Gavioli, Jose Fernando Oliveira-Costa, Milena Botelho Pereira Soares, Adley Antonini Neves de Lima, Daniel de Melo Silva, Telma Maria Araujo Moura Lemos
Summary: This study demonstrated that MHF has potential anti-inflammatory and analgesic effects without causing acute or subchronic toxic effects, making it a promising natural source for further exploration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Joaquim Felipe Junior, Gloria Maria de Franca, Caio Cesar da Silva Barros, Fernanda Aragao Felix, Weslay Rodrigues da Silva, Hevio Freitas de Lucena, Claudia Nunes Oliveira, Hebel Cavalcanti Galvao
Summary: This study analyzed the expression of epidermal growth factor receptor (EGFR), Cyclin D1, and transcription factor SOX2 in odontogenic cysts. The results showed that the cyst lining in all cases of odontogenic keratocysts (OKC), botryoid odontogenic cysts (BOC), and glandular odontogenic cysts (GOC) were positive for EGFR. The highest expression of nuclear Cyclin D1 was observed in the suprabasal layer of OKCs and in the basal and suprabasal layers of GOC and BOC. SOX2 was only expressed in the suprabasal layer of OKCs.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)
Article
Surgery
Livia Medeiros Soares Celani, Eryvaldo Socrates Tabosa Egito, Italo Medeiros Azevedo, Claudia Nunes Oliveira, Douglas Dourado, Aldo Cunha Medeiros
Summary: This study examined the effects of a negatively charged nanostructured curcumin microemulsion on experimental ulcerative colitis (UC) in rats. The results showed that the nanostructured curcumin microemulsion positively influenced antioxidant enzyme levels and significantly reduced the levels of pro-inflammatory cytokines. Furthermore, the severity of colonic mucosal ulcers was significantly reduced in the nanostructured curcumin group compared to the other groups. These findings suggest that nanostructured curcumin with negative zeta potential is a promising phytopharmaceutical oral delivery system for UC therapy.
ACTA CIRURGICA BRASILEIRA
(2022)
Article
Multidisciplinary Sciences
Andre F. Silva, Emmily C. C. Silva, Claudia N. Oliveira, Keyla B. F. Rocha, Marcia C. C. Miguel, Joabe S. Pereira
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2020)
Article
Infectious Diseases
Guilherme Holanda Bezerra, Monica Larissa Padilha Honorio, Vivianne Lira da Camara Costa, Hareton Teixeira Vechi, Manoella do Monte Alves, Maria Helena Marques Fonseca de Britto, Keyla Borges Ferreira Rocha, Luciana Distasio de Carvalho
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2020)
Article
Surgery
Vanessa de Fatima Lima Paiva Medeiros, Italo Medeiros Azevedo, Marilia Daniela Ferreira Carvalho, Claudia Nunes Oliveira, Eryvaldo Socrates Tabosa do Egito, Aldo Cunha Medeiros
ACTA CIRURGICA BRASILEIRA
(2017)
Article
Surgery
Italo Medeiros Azevedo, Robson Macedo Filho, Keyla Borges Ferreira Rocha, Claudia Nunes Oliveira, Aldo Cunha Medeiros
ACTA CIRURGICA BRASILEIRA
(2020)