Journal
ACS OMEGA
Volume 4, Issue 15, Pages 16292-16299Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.9b01317
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Funding
- Ministry of Science and Technology (MOST) of Taiwan [106-2113-M-009-013MY2, 106-2221-E-009-129-MY3]
- Center for Emergent Functional Matter Science of National Chiao Tung University Featured Areas Research Center Program within the framework of the Higher Education Sprout Project of the Ministry of Education (MOE) in Taiwan
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Open-surface microfluidics is promising in terms of enabling economical and rapid biochemical analysis for addressing challenges associated with medical diagnosis and food safety. To this end, we present a simple and economical approach to develop an open-surface microfluidic platform suitable for facile liquid transport and mixing. Customizable patterns with tailored wettability are deposited using a plasma-assisted deposition technique under atmospheric pressure. The flow of the dispensed liquid is driven by gravity, and the tilting angle of the device determines the extent of mixing. First, a hexamethyldisiloxane film was deposited to create hydrophobic patterns on glass, and then, hydrophilic acrylic acid was deposited by a patterned cardboard mask to construct a channel suitable for forming channels to transport aqueous liquids without the need of an external energy input; the liquid can be confined to designated pathways. Several designs including Y-junctions, serpentine-shaped patterns, splitting channels, and concentration gradient generation patterns are presented. The proposed method can spatially pattern a surface with a hydrophobic/hydrophilic area, which can function as a microfluidic channel, and the surface can be applied in microfluidic devices with other types of substrates.
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