Article
Environmental Sciences
Ali S. Alshehri, Attalla F. El-kott, Mohamed S. A. El-Gerbed, Ayman E. El-Kenawy, Ghadeer M. Albadrani, Heba S. Khalifa
Summary: The study evaluated the protective effect of kaempferol against cadmium chloride-induced liver damage through antioxidant and anti-inflammatory mechanisms, involving the upregulation of Nr12/HO-1 axis and suppression of NF-kappa B p65 and keap1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Sergio Davinelli, Luciano Saso, Floriana D'Angeli, Vittorio Calabrese, Mariano Intrieri, Giovanni Scapagnini
Summary: This article reviews the potential molecular mechanisms by which astaxanthin (AST) regulates the transcription factors Nrf2 and NF-κB, which are involved in oxidative stress and inflammation. Additionally, it summarizes the current clinical studies elucidating how AST alleviates the etiopathogenesis of oxidative stress and inflammation.
Article
Plant Sciences
Mengqin Liu, Sha Liu, Qi Zhang, Yingqi Fang, Yanwei Yu, Lulin Zhu, Yuling Liu, Wan Gong, Luying Zhao, Luping Qin, Qiaoyan Zhang
Summary: The study demonstrates that Curculigoside can alleviate oxidative stress and osteoclastogenesis by activating Nrf2 and inhibiting the NF-kappa B pathway, suggesting a potential therapeutic role in osteoporosis treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
Don A. Davies, Aida Adlimoghaddam, Benedict C. Albensi
Summary: Nrf2 impairments in neurodegenerative disorders, such as Alzheimer's disease, lead to oxidative stress, while Nrf2 activators can reverse memory and synaptic plasticity impairments associated with AD.
Article
Orthopedics
Peng Zhang, Yesheng Jin, Wei Xia, Xiaotong Wang, Zhiqiang Zhou
Summary: This study found that the active ingredient PHI from Forsythiae Fructus can alleviate IL-1 beta-induced inflammation cytokines and ECM degradation by activating Nrf2 and inhibiting the NF-kappa B pathway. This provides a biological rationale for the use of PHI as a potential candidate for OA treatment.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Nutrition & Dietetics
Yongfeng Zhang, Jie Hao, Zijian Liu, Zhige Li, Lirong Teng, Di Wang
Summary: This study investigated the regulatory effects of Inonotus hispidus (IH) on lipid metabolism in mice fed a high-fat diet (HFD). The results showed that IH could reverse the pathological state of the liver and fat, decrease the levels of LDL-C, TC, TG, and LEP, and increase the level of HDL-C in serum. Additionally, IH improved liver damage and modulated the gut microbiota. IH regulated the Nrf2/NF-κB signaling pathway and oxidative stress. These findings provide experimental evidence for the potential use of IH in obesity treatment.
Article
Biochemistry & Molecular Biology
Shujuan Li, Yan Li, Li Hou, Li Tang, Fang Gao
Summary: Forsythoside B hampers IL-1 beta-elicited rat chondrocyte apoptosis, oxidative stress, and facilitates proliferation. It suppresses the profiles of inflammatory factors and NOD-like receptor family pyrin domain containing 3 inflammasomes, as well as Kelch-like epichlorohydrin-associated protein-1 (Keap1) and nuclear factor-kappa B (NF-kappa B) phosphorylation, while promotes nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels. Furthermore, Forsythoside B mitigates cartilage damage and degeneration.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fengpei Zhang, Hui Xu, Yuan Yuan, Haichen Huang, Xiaoping Wu, Junli Zhang, Junsheng Fu
Summary: This study demonstrated that Lyophyllum decastes fruiting body polysaccharide (LDFP) protects against CCl4-induced acute liver injury in mice by activating the Nrf2 pathway, reducing inflammatory response, and improving antioxidant status in the liver.
Review
Biochemistry & Molecular Biology
Maja Jazvinscak Jembrek, Nada Orsolic, Lucija Mandic, Anja Sadzak, Suzana Segota
Summary: Neurodegenerative diseases are a major cause of disability and death worldwide, with pathways involving transcription factors playing a critical role in the pathological changes associated with oxidative stress and neuroinflammation. This review focuses on the role of transcription factor p53 in coordinating cellular response and potential therapeutic interventions using natural polyphenolic compounds with anti-oxidative, anti-inflammatory and anti-apoptotic effects. Further research is needed to fully understand the cellular and molecular mechanisms of these compounds for potential new treatments for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Hua-Wen Meng, Zhen-Bao Shen, Xian-She Meng, Ze-Qun Yin, Xue-Rui Wang, Ting-Feng Zou, Zhi-Gang Liu, Shuang Zhang, Yuan -Li Chen, Xiao-Xiao Yang, Qing-Shan Li, Ya-Jun Duan
Summary: In this study, a series of novel oxadiazole derivatives were designed and synthesized, among which compound F12 showed the best pharmacological activity. Compound F12 improved the dysfunction in a mouse model of Parkinson's disease by reducing oxidative stress and inflammatory response, and could be a potential treatment for Parkinson's disease.
BIOORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Xiangxiang Hu, Sing-Wai Wong, Kaixin Liang, Tai-Hsien Wu, Sheng Wang, Lufei Wang, Jie Liu, Mitsuo Yamauchi, Brian L. Foster, Jenny P. -Y. Ting, Baohong Zhao, Henry C. Tseng, Ching-Chang Ko
Summary: Degenerative diseases affecting the nervous and skeletal systems, such as neurodegenerative diseases and Paget's disease of bone, are influenced by the protein OPTN. OPTN and NRF2 show an age-related increase, and OPTN can interact with NRF2 and KEAP1 to up-regulate antioxidant response. Deletion of OPTN leads to increased oxidative stress and osteoclastogenesis, which can be attenuated by curcumin. These findings suggest the therapeutic potential of antioxidants for PDB.
Article
Biochemistry & Molecular Biology
Yong-er Chen, Shi-jie Xu, Ying-yu Lu, Shu-xian Chen, Xian-hua Du, Shao-zhen Hou, Hai-yang Huang, Jian Liang
Summary: The research demonstrates that asperuloside (ASP) has anti-inflammatory and antioxidant effects on DSS-induced chronic colitis, activating the Nrf2/HO-1 signaling pathway and inhibiting the NF-kappa B signaling pathway, making it a potential effective candidate for the treatment of IBD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Zhengle Zhang, Longjiang Chen, Chuanbing Zhao, Qiong Gong, Zhigang Tang, Hanjun Li, Jing Tao
Summary: This study reveals that CASC9 plays a key role in driving resistance to gemcitabine in pancreatic cancer. CASC9 forms a positive feedback loop with the NRF2-antioxidant signaling pathway and activates the NF-kappa B signaling pathway, contributing to gemcitabine resistance.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biology
Mengjue Tu, Xingshuo Fan, Jianan Shi, Shengnan Jing, Xiaole Xu, Yuqin Wang
Summary: This study demonstrates that 2-fluorofucose (2FF) can improve cell viability and reduce hydrogen peroxide (H2O2)-induced oxidative damage by inhibiting fucosylation. Furthermore, 2FF enhances antioxidant capacity and suppresses inflammation-associated protein expression through Nrf2/keap1 and NF-kappa B signaling pathways.
Review
Biochemistry & Molecular Biology
Sonia Emanuele, Adriana Celesia, Antonella D'Anneo, Marianna Lauricella, Daniela Carlisi, Anna De Blasio, Michela Giuliano
Summary: The article discusses the roles of Nrf2 in both cancer and COVID-19, highlighting its protective function in normal cells but potential overstimulation in tumor cells. Nrf2 exhibits different mechanisms of action in cancer and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Jamaan S. Ajarem, Ahmad K. Hegazy, Gamal A. Allam, Ahmed A. Allam, Saleh N. Maodaa, Ayman M. Mahmoud
Summary: This study evaluated the levels of heavy metals in Plantago ovata and domestic goats in the eastern region of Saudi Arabia, which were influenced by the petroleum industry. The results showed that the petroleum industry increased the levels of lead, cadmium, nickel, and vanadium in both the plant and animal samples, leading to liver and kidney injury, oxidative stress, and upregulation of pro-inflammatory and apoptosis markers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Sadaf Jamal Gilani, May Nasser Bin-Jumah, Syed Sarim Imam, Ameeduzzafar Zafar, Mohd Yasir, Sultan Alshehri, Muhammed M. Ghuneim
Summary: In this study, orally administered Osimertinib nanostructured lipid carriers (OSM-NLCs) were successfully prepared and evaluated for their drug release, permeation, and cytotoxicity against lung cancer cells. The results showed that OSM-NLCs exhibited high drug release and permeation flux, as well as lower cytotoxicity compared to pure OSM.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Syed Sarim Imam, Sadaf Jamal Gilani, Ameeduzzafar Zafar, May Nasser Bin Jumah, Sultan Alshehri
Summary: The present study aimed to develop MZBSo bilosomes and MZBSo gel. MZBSo presented nano-sized vesicles with high entrapment efficiency and suitable ζ potential, while MZBSoG2 showed good pH, viscosity, spreadability, and a slower drug release. MZBSoG2 was non-irritant and exhibited significant antifungal activity. Stability study results showed no significant changes. MZ-loaded gels could improve therapeutic efficacy.
Article
Plant Sciences
Fatimah Al-Otibi, Nourah A. A. Alshammry, Raedah I. I. Alharbi, May N. N. Bin-Jumah, Maha M. M. AlSubaie
Summary: The aqueous and ethanolic extracts of Artemisia sieberi showed significant antibacterial and antifungal effects against various microorganisms. Additionally, the synthesized silver nanoparticles from the A. sieberi extract exhibited stronger antibacterial properties. This research suggests that A. sieberi has potential as an antimicrobial agent.
Article
Biology
Bothina Mohammed Alharbi, Tahani H. Albinhassan, Razan Ali Alzahrani, Abderrezak Bouchama, Sameer Mohammad, Awatif Abdulaziz Alomari, May Nasser Bin-Jumah, Entissar S. AlSuhaibani, Shuja Shafi Malik
Summary: Rising temperatures and heat waves caused by climate change are detrimental to human health. Exposure to extreme heat during heat waves can cause heat-related illnesses, including heat stroke, which can result in permanent disability. Heat can damage proteins, leading to their misfolding and aggregation, which can be neurotoxic and contribute to neurodegenerative disorders.
Article
Chemistry, Inorganic & Nuclear
Imran Ali, Yasir Jamil, Saeed Ahmed Khan, Yunxiang Pan, Aqeel Ahmed Shah, Ali Dad Chandio, Sadaf Jamal Gilani, May Nasser Bin Jumah, Yusra Fazal, Jun Chen, Zhonghua Shen
Summary: The qualitative study of copper-cobalt ingot sample was conducted using laser induced breakdown spectroscopy (LIBS), and CuCo2O4 nanoparticles were synthesized using the alloy as a target material for Nd:YAG laser ablation. The composition and morphology of the synthesized nanoparticles were determined using various techniques including X-ray diffraction (XRD), energy dispersive X-ray (EDX) analysis, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and dynamic light scattering (DLS). The synthesized nanoparticles exhibited antibacterial activity and potential for magnetic hyperthermia.
Article
Chemistry, Inorganic & Nuclear
Imran Ali, Jun Chen, Saeed Ahmed Khan, Yasir Jamil, Aqeel Ahmed Shah, Abdul Karim Shah, Sadaf Jamal Gilani, May Nasser Bin Jumah, Yusra Fazal, Yunxiang Pan, Zhonghua Shen
Summary: Magneto-plasmonic Ag/Ni and Ag/Fe nanoparticles were synthesized using a dual-pulsed Q-switched Nd:YAG 1064 nm laser ablation method. The optical and magnetic properties were investigated, and the morphologies and phase structures of the nanoparticles were characterized. The synthesized nanoparticles exhibited plasmonic hyperthermia properties, reaching high temperatures when irradiated with a NIR 808 nm laser. These findings suggest the potential use of silver-based plasmonic nanoparticles for hyperthermia treatment.
Article
Chemistry, Analytical
Komal Majeed, Jaweria Ambreen, Saeed Ahmed Khan, Saz Muhammad, Aqeel Ahmed Shah, Muhammad Ali Bhatti, Syeda Sitwat Batool, Muhammad Farooq, Syed Nizam Uddin Shah Bukhari, Ali Dad Chandio, Sadaf Jamal Gilani, May Nasser Bin Jumah
Summary: Wastewater treatment is indispensable to prevent adverse health effects and deterioration of the quality of life on earth. Photocatalysis using nanocomposites of manganese oxide (Mn3O4) and nickel oxide (NiO) has been studied for its effectiveness in purifying wastewater. The synthesized nanomaterials were characterized using various techniques and the photocatalytic performance of the Mn3O4/NiO nanocomposite (NC) was evaluated. The results show that the NCs have a high photocatalytic degradation efficiency of 95% for removing methylene blue (MB) dye from wastewater.
Article
Food Science & Technology
Reem S. Alruhaimi, Emad H. M. Hassanein, May N. Bin-Jumah, Ayman M. Mahmoud
Summary: This study evaluated the protective effects of agomelatine (AGM) against cadmium (Cd)-induced cardiotoxicity in rats and found that AGM modulated the TLR-4/NF-kB pathway and HSP70. The results showed that AGM alleviated Cd-induced myocardial injury, reduced oxidative stress, and enhanced antioxidant effects.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mashael D. Alqahtani, May N. Bin Jumah, Saleha A. AlZahrani, Ahmed A. Allam, Mostafa R. Abukhadra, Stefano Bellucci
Summary: The biocompatible chitosan/zeolite-A (CS/ZA) and β-cyclodextrin/zeolite-A (CD/ZA) biocomposites were produced by hybridizing synthetic zeolite-A (ZA) with chitosan and β-cyclodextrin. The hybridization with the two biopolymers resulted in significant increases in the loading capacities of the 5-fluorouracil drug (5-Fu), with CD/ZA exhibiting the highest loading capacity. The release activities of 5-Fu from both CS/ZA and CD/ZA showed continuous and controlled profiles, with CD/ZA releasing the drug at a faster rate.
Article
Biochemistry & Molecular Biology
Hamna Shahid, Aqeel Ahmed Shah, Syed Nizam Uddin Shah Bukhari, Anjum Zehra Naqvi, Iqra Arooj, Mehvish Javeed, Muhammad Aslam, Ali Dad Chandio, Muhammad Farooq, Sadaf Jamal Gilani, May Nasser Bin Jumah
Summary: The synthesis of iron oxide nanoparticles using honey as a reducing and capping agent has shown significant antibacterial, antioxidant, and anti-inflammatory properties, making it a potential alternative to traditional antimicrobial drugs.
Article
Biochemistry & Molecular Biology
Mashael D. Alqahtani, May N. Bin Jumah, Abdulrahman Al-Hashimi, Ahmed A. Allam, Mostafa R. Abukhadra, Stefano Bellucci
Summary: In this study, natural bentonite clay was modified to enhance its drug loading capabilities for 5-fluorouracil. The modification process involved exfoliation of the clay into nanosheets and further functionalization with methanol. The modified carrier (Mth/EXBE) showed higher loading site density and faster drug release compared to the raw clay. Additionally, the cytotoxicity of 5-fluorouracil was significantly enhanced by the modified carriers.
Article
Biochemistry & Molecular Biology
Mashael Daghash Alqahtani, Nourhan Nasser, May N. N. Bin Jumah, Saleha A. A. AlZahrani, Ahmed A. A. Allam, Mostafa R. R. Abukhadra, Stefano Bellucci
Summary: Natural kaolinite can be modified into separated single nanosheets (KNs) and scrolled nanoparticles as nanotubes (KNTs). The synthetic nanostructures show advanced oxaliplatin-medication (OXAP) delivery systems. The loading capacity of KNs and KNTs is significantly increased compared to raw kaolinite, and they exhibit classic kinetic and isotherm behaviors. The release of OXAP from KNs and KNTs shows continuous and regulated profiles, with KNTs demonstrating faster release. The cytotoxicity of the synthesized structures is significantly enhanced on cancer cell lines, and they greatly increase the cytotoxicity of OXAP.
Article
Pharmacology & Pharmacy
Reem S. Alruhaimi, Emad H. M. Hassanein, May N. Bin-Jumah, Ayman M. Mahmoud
Summary: Pre-treatment with Agomelatine (AGM) exerts a protective effect against Cd-induced lung injury by regulating the Nrf2/HO-1 and SIRT1/FOXO3 signaling pathways, thereby exerting antioxidant and anti-apoptotic effects.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shaymaa A. Ramadan, Emadeldin M. Kamel, Reem S. Alruhaimi, Albandari Bin-Ammar, Madeha A. Ewais, Akef A. Khowailed, Emad H. M. Hassanein, Ayman M. Mahmoud
Summary: This study found that Caroxylon salicornicum has hepatoprotective effects, potentially by attenuating oxidative stress and inflammation, and upregulating Nrf2 and SIRT1.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
