Article
Biophysics
Shatadal Ghosh, Sayanta Dutta, Abhijit Sarkar, Mousumi Kundu, Parames C. Sil
Summary: Curcumin, a natural antioxidant, was delivered through Mesoporous silica nanoparticles to enhance its anticancer efficacy by targeting cancer cells with hyaluronic acid. The synthesized nanohybrid showed cell death in MDA-MB-231 cells and decreased tumor volume in tumor-bearing mice by inducing ROS, cell cycle arrest, and modulation of apoptotic pathways. Overall, the study found that the nanohybrid had increased anticancer efficacy compared to free curcumin.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Pharmacology & Pharmacy
Tais de Cassia Ribeiro, Rafael Miguel Sabio, Marcela Tavares Luiz, Lucas Canto de Souza, Bruno Fonseca-Santos, Luis Carlos Cides da Silva, Marcia Carvalho de Abreu Fantini, Cleopatra da Silva Planeta, Marlus Chorilli
Summary: This study investigated the use of curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) and a thermo-responsive hydrogel for the treatment of Alzheimer's disease (AD). The results showed that the MSN-CCM and hydrogel had excellent properties and high permeation values. In vivo studies confirmed the potential of the hydrogel-MSN-CCM formulation in reverting cognitive deficits in an AD model.
Review
Medicine, Research & Experimental
Saurabh Shah, Paras Famta, Deepkumar Bagasariya, Kondasingh Charankumar, Anupama Sikder, Rama Kashikar, Arun K. Kotha, Mahavir Bhupal Chougule, Dharmendra Kumar Khatri, Amit Asthana, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava
Summary: This review highlights the importance of mesoporous silica nanoparticles (MSN) as delivery vehicles in cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters affecting MSN synthesis, drug loading characteristics, and targeting cancer cells specifically are explained. The applications and potential of MSN in nanotheranostics and imaging are illustrated. The review also discusses the hurdles encountered during the translation process and potential solutions.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Analytical
Albert Yu, Xiaoyong Dai, Zixian Wang, Huaqing Chen, Bing Guo, Laiqiang Huang
Summary: Immunotherapy is a promising treatment modality for cancer, using the body's immune response to fight against cancer. Mesoporous silica, as a nanomaterial, can facilitate the advancement of immunotherapy with its high porosity and biocompatibility.
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Joohyeon Kim, Yejin Kim, Sohyeon Yu, Jisu Kim, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Cancer remains a major global health challenge, and traditional chemotherapy often leads to side effects and drug resistance, necessitating the development of alternative treatments like gene therapy. Mesoporous silica nanoparticles (MSNs) offer numerous advantages as gene delivery carriers, including high loading capacity, controlled drug release, and easy surface functionalization. They are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies have reviewed the use of MSNs for delivering therapeutic nucleic acids to cancer cells and discussed their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are also discussed.
Review
Pharmacology & Pharmacy
Xiaowei Xie, Tianxiang Yue, Wenting Gu, Weiyi Cheng, Li He, Weiye Ren, Fanzhu Li, Ji-Gang Piao
Summary: This paper discusses the use of surface-functionalized mesoporous silica nanoparticles (MSN) as delivery vehicles for siRNA in cancer therapy. The advantages of using MSNs for siRNA loading and strategies to improve cellular uptake and endosomal escape are highlighted. Attention is also paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Lara G. Freidus, Pradeep Kumar, Thashree Marimuthu, Priyamvada Pradeep, Yahya E. Choonara
Summary: A novel theranostic molecule termed CurNQ, derived from Cur and NQ, has been synthesized and loaded into mesoporous silica nanoparticles to form MSN_CurNQ, which showed enhanced drug delivery and pH-responsive release of CurNQ. The fluorescence characteristics of MSN_CurNQ allow for tracking and detection, while its chemotherapeutic potential was demonstrated in vitro, particularly in cancer cell lines with tumor-specific toxicity. The novel nanosystem MSN_CurNQ holds promise for applications in cancer targeting, detection, and treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Ozi Adi Saputra, Windy Ayu Lestari, Wahyu Nur Safitriono, Murni Handayani, Witri Wahyu Lestari, Fajar Rakhman Wibowo
Summary: The study successfully prepared surface-modified magnetic mesoporous silica nanoparticles with high loading capacity, which can prevent premature drug release and achieve controlled release under different pH conditions. The nanoparticles also demonstrated good magnetic properties, potentially extending to magnetic hyperthermia for cancer therapy.
Article
Chemistry, Analytical
Lele Zhou, Lu Wang, Ning Ma, Yizhen Wan, Yu Zhang, Hao Liu, Weiping Qian
Summary: This study developed a novel and effective strategy to monitor the real-time release of hydrophobic cargo curcumin using a lipid-curcumin-loaded silica colloidal crystal film controlled by lipase. The degradation of a digestible lipid complex triggered by lipase resulted in the real-time release of curcumin, which was tracked by changes in optical thickness. The study also found that the addition of soluble dietary fiber delayed the release rate of curcumin.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Physical
Arezoo Sodagar Taleghani, Ali Taghvaie Nakhjiri, Mohammad Javad Khakzad, Seyed Mahdi Rezayat, Pedram Ebrahimnejad, Amir Heydarinasab, Azim Akbarzadeh, Azam Marjani
Summary: In recent decades, significant progress has been made in cancer treatment, but finding more effective therapies is crucial. The application of drug delivery nanovehicles, particularly mesoporous silica nanoparticles (MSNPs), shows promise in reducing side effects. MSNPs possess excellent characteristics that make them suitable for targeted and stimuli responsive drug delivery in cancer treatment.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Nanoscience & Nanotechnology
Nora Igaz, Peter Belteky, David Kovacs, Csaba Papp, Andrea Ronavari, Diana Szabo, Attila Gacser, Zoltan Konya, Monika Kiricsi
Summary: The efficient delivery of Rhodamine 123 and Mitomycin C to multidrug-resistant cells via mesoporous silica nanoparticles (MSNs), resulting in increased intracellular drug concentration and enhanced cytotoxic effects, demonstrates the enormous potential of MSNs in overcoming multidrug-resistant cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Hanh-Vy Tran Nguyen, Bao Quang Gia Le, Thu-Ha Thi Nguyen, Quyen Toan Pham, Minh-Tri Le, Toi Van Vo, Nhu-Thuy Trinh, Thi-Hiep Nguyen, Tan Le Hoang Doan, Ngoc Xuan Dat Mai, Long Binh Vong
Summary: The functionalization of mesoporous silica nanoparticles (MSN) with phosphonate groups (-PO3) facilitated the targeted delivery of curcumin to cancer cells and greatly improved the stability of the nanomaterial. The modified particles showed maintained structural integrity and exhibited potent efficacy against colorectal cancer cells.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lihong Fan, Yuqing Lu, Xiao-kun Ouyang, Junhong Ling
Summary: By embedding curcumin in core-shell nanoparticles using protein-polysaccharide complexes, the stability and dispersibility of Cur were effectively enhanced, providing a simple method for Cur delivery with potential applications for delivering lipid-soluble active ingredients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Han Zhao, Xiao-Kun Ouyang, Li-Ye Yang
Summary: The cellulose nanofiber and sodium alginate adsorbent prepared through a cross-linking method showed efficient removal of Pb(II), with fast adsorption equilibrium, high adsorption capacity, and good cycling regeneration performance.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Quan Wang, Fangyuan Jiang, Xiao-Kun Ouyang, Li-Ye Yang, Yangguang Wang
Summary: Using mussel shell powder as an adsorbent to remove contaminants from water was studied, with various characterizations confirming its adsorption performance, especially for Pb(II).
Article
Biochemical Research Methods
Minlan Li, Haozhan Feng, Xiaokun Ouyang, Junhong Ling
Summary: Fucoxanthin, a carotenoid natural product, has been found in various algae species, including those not traditionally considered producers of this compound. The development of a HPLC-UV method and HPLC-time-of-flight mass spectrometry has allowed for quantification and confirmation of fucoxanthin production in algae, highlighting the commercial potential for macroalgal biomass in producing this compound.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2021)
Article
Chemistry, Physical
Hong Zhang, Liyang Jiang, Mengdan Tong, Yi Lu, Xiao-Kun Ouyang, Junhong Ling
Summary: The composite nanosystem prepared with fucoidan and zein demonstrated good stability and high encapsulation efficiency for hydrophobic active substances encapsulation and delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Environmental
Jian Shen, Fangyuan Jiang, Nan Wang, Xiao-kun Ouyang, Mi-cong Jin
Summary: A mild cellulose modification method was proposed in this study, leading to the preparation of magnetic carboxylic functionalized CNC and systematic investigation of its adsorption process, properties, and effects. The results demonstrate that MCNC-DPTA is an environment-friendly adsorption material with excellent Pb(II) removal effect.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Engineering, Environmental
Jian Shen, Xinyi Xu, Xiao-kun Ouyang, Mi-cong Jin
Summary: Nanocrystalline cellulose/sodium alginate/K-carrageenan composite hydrogel beads were prepared and demonstrated to have excellent potential for heavy metal ion adsorption. The tricomponent hydrogel beads exhibited robustness, improved adsorption capacity for Pb2+, and good reusability, with a maximum adsorption capacity of 351.04 mg g(-1) and high adsorption capacity retained after five cycles of reuse.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Engineering, Biomedical
Zimu Li, Zhidong Chen, Hongzhong Chen, Kebing Chen, Wei Tao, Xiao-kun Ouyang, Lin Mei, Xiaowei Zeng
Summary: Polyphenol-based hydrogels, as nature-derived bioactive materials, possess unique properties and have been widely used in biomedical fields. This review elaborates the evolution process of these hydrogels from crosslinking structures to biomedical applications and proposes efficient design considerations.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhihui Chen, Hua-Neng Xu, Xiao-Kun Ouyang
Summary: We have developed a method to prepare cellulose nanocrystals from the fruit shell of Camellia oleifera Abel. The hydrolysis time has been found to affect the characteristics of the nanocrystals, such as size, morphology, surface charge, and crystallinity. This controlled acid hydrolysis approach offers a conventional and scalable way to tailor the properties of cellulose nanocrystals.
Article
Pharmacology & Pharmacy
Chennan Liu, Fangyuan Jiang, Zifeng Xing, Lihong Fan, Yuan Li, Shaoning Wang, Junhong Ling, Xiao-Kun Ouyang
Summary: In this study, we successfully synthesized a novel nanoparticle MSN-NH2-AOS for the delivery of the fat-soluble drug curcumin. The optimized preparation process resulted in high drug encapsulation efficiency and tumor cell targeting of the nanoparticles, which showed strong cytotoxicity against tumor cells.
Article
Pharmacology & Pharmacy
Haozhan Feng, Minlan Li, Zifeng Xing, Xiao-kun Ouyang, Junhong Ling
Summary: Fucoxanthin, a natural carotenoid pigment found in brown seaweed, has shown antitumor activity. However, its effectiveness as a therapeutic agent is limited due to low bioavailability, poor water solubility, and poor physicochemical stability. In this study, a targeted magnetic, acid-labile nano-carrier was designed and constructed to improve the bioactivity of Fucoxanthin based on the acidic nature of the tumor microenvironment. The nano-carrier exhibited sustained and pH-dependent drug release, leading to improved stability and bioavailability of Fucoxanthin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Guo Yi, Junhong Ling, Yongjun Jiang, YuQing Lu, Li-Ye Yang, Xiao-kun Ouyang
Summary: In this study, pH-sensitive chito-oligosaccharide nano-drug-loaded particles were developed with good bio-compatibility, biodegradation, and controlled drug delivery. The nanoparticles demonstrated site targeting under weak acidic tumor conditions, improved drug efficacy, and reduced toxic side effects.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Yuhong Tian, Yongjun Jiang, Zhengshun Wen, Liping Guan, Xiaokun Ouyang, Wanjing Ding, Zhongjun Ma
Summary: Lipid-lowering is an effective method for preventing and treating cardiovascular diseases, and developing safe and effective novel lipid-lowering drugs is of great significance. We discovered that the organic crude extracts of Nocardiopsis sp. ZHD001 exhibited strong lipid-lowering effects in high-fat-diet-fed mice models. Chemical investigations led to the identification of two new sphydrofuran-derived compounds and one known compound. Bioactivity evaluations showed that these compounds exhibited significant lipid-lowering activity with lower cytotoxicity compared to simvastatin. Our results suggest that sphydrofuran-derived compounds may be promising candidates for lipid-lowering drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hongping Xu, Junhong Ling, Han Zhao, Xinyi Xu, Xiao-kun Ouyang, Xiaoyong Song
Summary: Chemotherapy is widely used for tumor treatment, but it causes the death of normal cells due to non-specific drug distribution. This study developed a novel nanocarrier, MPDA-DOX@FU-SS, which can achieve targeted drug release in the tumor microenvironment. The nanocarrier showed significant inhibition of tumor cell growth.
Article
Biochemistry & Molecular Biology
Mengwen Guo, Junhong Ling, Xinyi Xu, Xiaokun Ouyang
Summary: In this study, a simple and effective method for developing a nanotherapeutic agent for chemotherapy combined with photothermal therapy was presented. The agent consisted of mesoporous polydopamine modified by ferric ions and loaded with the anticancer drug doxorubicin, as well as an outer layer coating of hyaluronic acid. The findings showed that the nanotherapeutic agent had enhanced heat generation effect and demonstrated potent cytotoxicity to tumor cells under near-infrared light illumination. This system deserves further investigation as a potential nanotherapeutic platform for photothermal treatment of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
