Cinobufagin Induces Cell Cycle Arrest at the G2/M Phase and Promotes Apoptosis in Malignant Melanoma Cells

The anticancer effects of cinobufagin on hepatocellular carcinoma Huh‑7�cells are associated with activation of the p73 signaling pathway

(2019) Lei Zhao et al.   Molecular Medicine Reports

Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway

(2019) Li Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Venenum bufonis: An overview of its traditional use, natural product chemistry, pharmacology, pharmacokinetics and toxicology

(2019) Wen-Long Wei et al.   JOURNAL OF ETHNOPHARMACOLOGY

A retrospective chart review study describing metastatic melanoma patients profile and treatment patterns in Spain

(2019) I. Márquez-Rodas et al.   Clinical & Translational Oncology

The adjuvant treatment revolution for high-risk melanoma patients

(2019) Francesco Spagnolo et al.   SEMINARS IN CANCER BIOLOGY

c-Myc regulates the CDK1/cyclin B1 dependent‑G2/M cell cycle progression by histone H4 acetylation in Raji cells

(2018) Yan Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A Series of Enthalpically Optimized Docetaxel Analogues Exhibiting Enhanced Antitumor Activity and Water Solubility

(2018) Yun-Tao Ma et al.   JOURNAL OF NATURAL PRODUCTS

H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo

(2018) Yanting Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A complex micellar system co-delivering curcumin with doxorubicin against cardiotoxicity and tumor growth

(2018) Di Zhang et al.   International Journal of Nanomedicine

Inhibitory effect of vanillin on RANKL-induced osteoclast formation and function through activating mitochondrial-dependent apoptosis signaling pathway

(2018) Yueqi Chen et al.   LIFE SCIENCES

Bmp4 inhibits goose granulosa cell apoptosis via PI3K/AKT/Caspase-9 signaling pathway

(2018) Junsong Yuan et al.   ANIMAL REPRODUCTION SCIENCE

Nivolumab and ipilimumab: immunotherapy for treatment of malignant melanoma

(2018) Nicole A Carreau et al.   Future Oncology

Anticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma

(2018) Wenwen Pang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-proliferative and pro-apoptotic effects of cinobufagin on human breast cancer MCF-7 cells and its molecular mechanism

(2017) Ling Zhu et al.   NATURAL PRODUCT RESEARCH

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

Association between Cataract and Keratinocytic Skin Cancers or Melanoma: Speculating on the Common Role of Sun and Ultraviolet Radiation Exposures

(2017) David Varssano et al.   OPHTHALMIC EPIDEMIOLOGY

The synergistic antitumor effect of cinobufagin and cisplatin in human osteosarcoma cell line in vitro and in vivo

(2017) Guo Dai et al.   Oncotarget

Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle

(2017) Hui Xiao Chao et al.   Cell Systems

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

(2017) Guangyao Lv et al.   Acta Pharmaceutica Sinica B

7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells

(2016) Mei-Chi Chang et al.   Oncotarget

Preclinical study of cinobufagin as a promising anti-colorectal cancer agent

(2016) Xing-sheng Lu et al.   Oncotarget

Photodynamic Therapy for Non-Melanoma Skin Cancers

(2016) Diana Cohen et al.   Cancers

Long-Term Outcomes and Prognostic Factors of High-Risk Malignant Melanoma Patients after Surgery and Adjuvant High-Dose Interferon Treatment: A Single-Center Experience

(2015) Tulay Akman et al.   CHEMOTHERAPY

Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway

(2015) Li-Juan Deng et al.   Oncotarget

Principles of Surgical Treatment of Malignant Melanoma

(2014) Charles W. Kimbrough et al.   SURGICAL CLINICS OF NORTH AMERICA

A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Localβ-Endorphin ExpressionIn Vivo

(2013) Tao Chen et al.   Evidence-based Complementary and Alternative Medicine

Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis

(2012) Dong-Mei Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DNA damage checkpoints in stem cells, ageing and cancer

(2012) Tobias Sperka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-specific Incidence Ratios in Malignant Melanoma in Turkey: Melanoma in Older People is Increasing

(2011) F Tas   ACTA DERMATO-VENEREOLOGICA

Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways

(2011) Fanghua Qi et al.   CANCER SCIENCE

Apoptotic and anti-metastatic effects of the whole skin of Venenum bufonis in A549 human lung cancer cells

(2011) JEONG-SEOK PARK et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anti-hepatitis B Virus Activities of Cinobufacini and Its Active Components Bufalin and Cinobufagin in HepG2.2.15 Cells

(2010) Xiaoyan Cui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

(2009) Zhiqiang Meng et al.   CANCER

Phase II Study of Picoplatin As Second-Line Therapy for Patients With Small-Cell Lung Cancer

(2009) John R. Eckardt et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Trial of Pemetrexed Plus Bevacizumab for Second-Line Therapy of Patients With Advanced Non–Small-Cell Lung Cancer: NCCTG and SWOG Study N0426

(2009) Alex A. Adjei et al.   JOURNAL OF CLINICAL ONCOLOGY

Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells

(2008) Ching-Han Yu et al.   CANCER SCIENCE