Article
Medicine, Research & Experimental
Chun-Lin Liu, Trung-Loc Ho, Shuen-Yih Fang, Jeng-Hung Guo, Chih-Ying Wu, Yi-Chin Fong, Chih-Chuang Liaw, Chih-Hsin Tang
Summary: Ugonin L extracted from Helminthostachys zeylanica shows potential in reducing bone resorption and may serve as a candidate for the development of novel therapies for bone loss-related diseases such as osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Hye Jung Ihn, Jiwon Lim, Kiryeong Kim, Sang-Hyeon Nam, Soomin Lim, Su Jeong Lee, Jong-Sup Bae, Tae Hoon Kim, Jung-Eun Kim, Moon-Chang Baek, Yong Chul Bae, Eui Kyun Park
Summary: Ciclopirox effectively inhibits osteoclast differentiation and bone resorption both in vitro and in vivo, making it a potential candidate for preventing osteoporosis and other osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pedro P. C. de Souza, Petra Henning, Ulf H. Lerner
Summary: Oncostatin M (OSM) is a potent stimulator of osteoclast formation and plays a significant role in bone remodeling by inducing RANKL in osteoblasts. Gene deletion of Osmr in mice leads to decreased osteoclast numbers and increased trabecular bone thickness. OSM can promote osteoblast differentiation and mineralization, but in vivo administration in adult animals does not significantly increase osteoclast formation due to the negative feedback loop through the osteoclastogenesis inhibitor WNT16.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Yifeng Shi, Lin Ye, Shiwei Shen, Tianchen Qian, Youjin Pan, Yuhan Jiang, Jinghao Lin, Chen Liu, Yaosen Wu, Xiangyang Wang, Jiake Xu, Haiming Jin
Summary: The study demonstrated that morin can inhibit osteoclast formation through various pathways and attenuate bone loss induced by ovariectomy. This suggests that morin may be a potential therapeutic agent for postmenopausal osteoporosis treatment.
PHYTOTHERAPY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Yan Li, Lingyu Li, Xiaoyun Li, Bingjie Luo, Qianyun Ye, Haoyu Wang, Li Yang, Xiaofeng Zhu, Li Han, Ronghua Zhang, Huaqin Tian, Panpan Wang
Summary: Bone reconstruction relies on the balance between bone formation and bone absorption. Polyphenols found in Chinese herbal medicines can affect this balance and have potential therapeutic effects on bone metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Daniel de Melo Pereira, Noel Davison, Pamela Habibovic
Summary: Biomineralized collagen composite materials, as an alternative to synthetic bone graft substitutes, offer a biomimetic composition similar to natural bone. In this study, we found phenotypic differences in activity and actin ring formation of human osteoclasts cultured on biomineralized collagen and pure collagen membranes, providing insights for optimized design.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Perry C. Caviness, Dongzheng Gai, Oxana P. Lazarenko, Michael L. Blackburn, Fenghuang Zhan, Jin-Ran Chen
Summary: Osteoclasts derived from hematopoietic stem cells play a crucial role in bone resorption. Identifying new molecules that can epigenetically regulate osteoclastogenesis is essential for the development of novel treatments for bone deterioration disorders like osteoporosis. The protein Ezh2 has been found to be associated with the epigenetic regulation of various cellular processes, but its role in bone cell development is still not fully understood.
Review
Cell Biology
Margaret M. Durdan, Ruth D. Azaria, Megan M. Weivoda
Summary: Bone remodeling involves the coordination of resorption by osteoclasts and formation by osteoblasts to maintain skeletal mass. This review focuses on the essential role of osteoclasts in coupling resorption to bone formation, the mechanisms of this coupling, and the disruptions that occur in conditions of bone loss. The targeting of coupling to treat human bone disease is also discussed.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Hirohito Hirata, Asana Kamohara, Masatoshi Murayama, Kenichi Nishioka, Hiroaki Honda, Yasuteru Urano, Hidenobu Soejima, Shinya Oki, Toshio Kukita, Shunsuke Kawano, Masaaki Mawatari, Akiko Kukita
Summary: Bhlhe40 is a crucial regulator of osteoclast differentiation and function, and its deficiency leads to increased bone volume and reduced bone resorption activity. Analysis of potential target genes reveals their association with proton transport and intracellular vesicle acidification.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Takahiro Noguchi, Hideki Kitaura, Aseel Marahleh, Afifah Zahra Agista, Yusuke Ohsaki, Hitoshi Shirakawa, Itaru Mizoguchi
Summary: Fermented rice bran (FRB) serves as a supplement with anti-inflammatory properties that can mitigate osteoclastogenesis and bone resorption induced by lipopolysaccharide (LPS) by controlling TNF-a expression in macrophages and directly inhibiting osteoclast formation.
Article
Biochemistry & Molecular Biology
Xuan Liu, Li Diao, Yudie Zhang, Xue Yang, Junnan Zhou, Yuhang Mao, Xiaotian Shi, Fuli Zhao, Mei Liu
Summary: Piperlongumine (PL), a compound from Piper longum fruits, can inhibit osteoclast formation and activation, reduce the expression of osteoclastic marker genes, and suppress NF-kappa B activation. PL can also ameliorate titanium particle-induced bone loss in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ling Ji, Xinyi Li, Shushu He, Song Chen
Summary: This review introduces the pathways and related microRNAs involved in osteoclastogenesis, discusses the clinical potential of targeting microRNAs for the treatment of osteoclast-mediated bone resorption, and the challenges of avoiding potential side effects and producing efficient delivery methods.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ari Elson, Anuj Anuj, Maayan Barnea-Zohar, Nina Reuven
Summary: Osteoclasts are hematopoietic cells that play a key role in degrading bone by secreting protons and proteases. Insufficient or excessive activity of osteoclasts can lead to changes in bone mass and exacerbate symptoms of diseases. Osteoclasts derive from two embryonic cell lineages and undergo a multi-stage process that involves cell differentiation, fusion, and further maturation. Recent studies also suggest the ability of osteoclasts to undergo fission and recycling.
Article
Biochemistry & Molecular Biology
Jin-Young Lee, Da-Ae Kim, Eun-Young Kim, Eun-Ju Chang, So-Jeong Park, Beom-Jun Kim
Summary: Lumican inhibits osteoclastogenesis by suppressing Akt activity, leading to an osteoprotective role by simultaneously increasing bone formation and decreasing bone resorption, suggesting it represents a dual-action therapeutic target for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Zihan Deng, Wenhui Hu, Hongbo Ai, Yueqi Chen, Shiwu Dong
Summary: Interferons (IFNs) are cytokines that play crucial roles in regulating immunity and maintaining the balance of bone matrix by affecting the communication between osteoblasts and osteoclasts. Different types of IFNs have diverse effects on the dynamic equilibrium of the skeletal system, contributing to the overall health of bones.
CURRENT GENE THERAPY
(2021)
Article
Engineering, Biomedical
Yong Tang, Keyu Luo, Jiulin Tan, Rui Zhou, Yueqi Chen, Can Chen, Zhigang Rong, Moyuan Deng, Xueke Yu, Chengmin Zhang, Qijie Dai, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo
Summary: Selective cell retention technology plays a crucial role in bone tissue engineering, and by designing appropriate scaffolds, cell adhesion, proliferation, and differentiation can be promoted to accelerate bone regeneration and angiogenesis. The newly developed scaffold holds potential for clinical applications.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Yong Tang, Keyu Luo, Yin Chen, Yueqi Chen, Rui Zhou, Can Chen, Jiulin Tan, Moyuan Deng, Qijie Dai, Xueke Yu, Jian Liu, Chengmin Zhang, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo
Summary: The phosphorylation state of PTP1B Y152 plays a central role in initiating the departure of cells from their niches during bone regeneration. A peptide called 152RM was found to promote cell migration via integrin avp3, enhance MSCs osteogenic differentiation by inhibiting ATF3, and induce type H vessels formation by activating Notch signaling. In vivo studies showed that DBM-MSN/152RM scaffolds were effective in inducing bone formation and type H vessels expansion.
BIOACTIVE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Zhiguo Ling, Chuan Yang, Jiulin Tan, Ce Dou, Yueqi Chen
Summary: MDSCs, a heterogeneous population of immature myeloid cells with immunosuppressive functions, play crucial roles in cancer-related bone metastasis and bone repair. They interact closely with stromal cells within the bone microenvironment and have promising value in the treatment of bone-related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Engineering, Biomedical
Ce Dou, Jianmei Li, Jian He, Fei Luo, Tao Yu, Qijie Dai, Yueqi Chen, Jianzhong Xu, Xiaochao Yang, Shiwu Dong
Summary: A novel bone-targeted nanomaterial was designed for selectively eliminating mature osteoclasts while preserving beneficial preosteoclasts, showing better protective effects in treating osteoporosis with improved bone formation and vascularization. This study provides a new anabolic therapeutic strategy for bone disorders with excessive bone resorption.
BIOACTIVE MATERIALS
(2021)
Correction
Engineering, Biomedical
Yong Tang, Keyu Luo, Yin Chen, Yueqi Chen, Rui Zhou, Can Chen, Jiulin Tan, Moyuan Deng, Qijie Dai, Xueke Yu, Jian Liu, Chengmin Zhang, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo
BIOACTIVE MATERIALS
(2021)
Review
Cell Biology
Chuan Yang, Zicai Dong, Zhiguo Ling, Yueqi Chen
Summary: This review discusses the role of RNA methylation in bone metabolism and its impact on bone diseases. It summarizes advanced technologies for detecting RNA methylation and explores the potential of RNA methylation in early diagnosis and therapeutic implications for bone-related diseases. The aim of this review is to establish a theoretical basis for further research in this meaningful field.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell Biology
Yutong Wu, Hongbo Ai, Yuhang Xi, Pengbin Yin, Ying Qu, Jianzhong Xu, Ce Dou, Fei Luo
Summary: Osteoporosis is related to excessive activity of osteoclasts. Most osteoclasts undergo apoptosis after bone resorption and produce a large number of apoptotic bodies. However, the biological function of osteoclast-derived apoptotic bodies in the progression of osteoporosis is still unknown.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Zicai Dong, Chuan Yang, Jiulin Tan, Ce Dou, Yueqi Chen
Summary: The skeletal system is a dynamically balanced system, and SIRT6 plays important roles in bone-related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and intervertebral disc degeneration. We summarize the critical roles of SIRT6 in these diseases and the relevant signaling pathways, and discuss the advances in the development of SIRT6 activators and their pharmacological profiles, providing novel treatment strategies for these skeletal diseases.
Article
Cell Biology
Yutong Wu, Hongbo Ai, Yuhang Xi, Jiulin Tan, Ying Qu, Jianzhong Xu, Fei Luo, Ce Dou
Summary: The bone microenvironment plays a role in promoting cancer cell proliferation and dissemination through apoptotic bodies (ABs) produced by osteoclasts. In this study, it was discovered that AB-null mice showed resistance to breast cancer cell implantation, with increased CD8+ T cell infiltrations and higher survival rate. The researchers found that membranous Siglec15 on osteoclast-derived ABs binds with sialylated Toll-like receptor 2 (TLR2) and inhibits activation of naive CD8+ T cells. Furthermore, treatment with Siglec15 neutralizing antibodies decreased secondary metastases and improved the survival rate in mice with advanced breast cancer bone metastasis. These findings reveal the immunosuppressive function of osteoclast-derived ABs in the bone-tumor niche and highlight the potential of Siglec15 as a target for anti-resorption and immunotherapy.
CELL REPORTS MEDICINE
(2023)
Article
Cell & Tissue Engineering
Ce Dou, Gehua Zhen, Yang Dan, Mei Wan, Nathachit Limjunyawong, Xu Cao
Summary: The process of cell recognition mediated by Siglec15-TLR2 binding is essential for osteoclast formation and occurs before cell fusion in RANKL-mediated osteoclastogenesis. The binding of sialylated TLR2 to Siglec15 initiates cell fusion, and the expression of Siglec15 is activated by M-CSF while ST3Gal1 expression is induced by RANKL. Deletion of Siglec15 or inhibition of sialylation abrogates cell recognition and reduces osteoclast formation.
Review
Biochemistry & Molecular Biology
Bo Wang, Yutong Dong, Zhansong Tian, Yueqi Chen, Shiwu Dong
Summary: Numerous studies have shown that the skeletal system closely coordinates with the immune system, with dendritic cells and osteoclasts cooperating to mediate bone destruction and remodeling under inflammatory conditions.
Review
Rheumatology
Wenhui Hu, Yueqi Chen, Ce Dou, Shiwu Dong
Summary: This article discusses the changes in subchondral bone during OA progression and potential strategies for treating OA, including restoring abnormal remodeling and blocking blood vessels, highlighting the relationship between the subchondral bone microenvironment and OA pain.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Cell & Tissue Engineering
Qinyu Ma, Mengmeng Liang, Yutong Wu, Fei Luo, Zaisong Ma, Shiwu Dong, Jianzhong Xu, Ce Dou
Summary: The study identified the molecular profile of apoptotic bodies (ABs) derived from osteoclasts at different differentiation stages, showing marked differences in protein cargo and high similarity to parental cells. Functionally, pOC-ABs promoted endothelial progenitor cell differentiation and endothelial cell formation, while mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling, highlighting the important biological roles of ABs in coupling bone formation with resorption during bone remodeling.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
