mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn’s Disease

Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11

(2019) Federica Ungaro et al.   INTERNATIONAL JOURNAL OF CANCER

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile

(2018) Jesse Lyons et al.   PLOS BIOLOGY

MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice

(2017) Federica Ungaro et al.   GASTROENTEROLOGY

MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells

(2017) Russell G. Jones et al.   IMMUNITY

IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation

(2017) Fabienne Venet et al.   JOURNAL OF IMMUNOLOGY

Crohn's disease

(2017) Joana Torres et al.   LANCET

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

(2017) Mee-Sup Yoon   Nutrients

Emerging Roles of Lymphatic Vasculature in Immunity

(2017) Ki-Wook Kim et al.   Immune Network

Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease

(2016) Gwendalyn J. Randolph et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

T Cell Trafficking through Lymphatic Vessels

(2016) Morgan C. Hunter et al.   Frontiers in Immunology

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

(2016) Shurong Hu et al.   PLoS One

VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

(2014) Silvia D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children

(2014) Mohamed Mutalib et al.   Journal of Crohns & Colitis

Control of dendritic cell trafficking in lymphatics by chemokines

(2013) Louise A. Johnson et al.   ANGIOGENESIS

Decreased Lymphatic Vessel Density Is Associated With Postoperative Endoscopic Recurrence in Crohn’s Disease

(2013) Jean-François Rahier et al.   INFLAMMATORY BOWEL DISEASES

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Pharmacological Control of Autophagy: Therapeutic Perspectives in Inflammatory Bowel Disease and Colorectal Cancer

(2012) Sofia Garcia-Maurino et al.   CURRENT PHARMACEUTICAL DESIGN

Role of the lymphatic system in the pathogenesis of Crohnʼs disease

(2011) Pierre-Yves von der Weid et al.   CURRENT OPINION IN GASTROENTEROLOGY

IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation

(2009) Troels Hammer et al.   MICROVASCULAR RESEARCH

A Multicenter, Randomized, Double-Blind Trial of EverolimusVersusAzathioprine and Placebo to Maintain Steroid-Induced Remission in Patients With Moderate-to-Severe Active Crohn's Disease

(2008) Walter Reinisch et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Use of sirolimus (rapamycin) to treat refractory Crohn's disease

(2008) D C O Massey et al.   GUT