Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells

The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

(2019) Zehui Li et al.   BMC CANCER

Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents

(2019) Yi-Min Liu et al.   Future Medicinal Chemistry

Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells

(2019) Massimo Romani et al.   Cancers

Targeting autophagy in cancer

(2018) Angelique V. Onorati et al.   CANCER

Autophagy inhibition improves anti-cancer drugs via FOXO3a activation

(2018) Brent E. Fitzwalter et al.   Oncotarget

Chalcomoracin is a potent anticancer agent acting through triggering Oxidative stress via a mitophagy- and paraptosis-dependent mechanism

(2018) Haote Han et al.   Scientific Reports

EGFR amplification induces sensitivity to antiEGFR therapy in pancreatic acinar cell carcinoma

(2018) Corentin Richard et al.   World Journal of Gastrointestinal Oncology

The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers

(2018) Ran Xu et al.   MEDICINE

Neoadjuvant Treatment for Pancreatic Cancer

(2018) Alexander G. Raufi et al.   SEMINARS IN ONCOLOGY

PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.

(2018) Vito W Rebecca et al.   Cancer Discovery

Hydroxychloroquine retinopathy

(2017) I H Yusuf et al.   EYE

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

Pancreatic Cancer Chemoresistance to Gemcitabine

(2017) Manoj Amrutkar et al.   Cancers

Research progress of hydroxychloroquine and autophagy inhibitors on cancer

(2016) Ting-Ting Shi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Novel pharmacological modulators of autophagy: an updated patent review (2012-2015)

(2016) Joohun Ha et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress

(2016) ZHONGLIANG WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo

(2016) Chun-Han Chen et al.   Oncotarget

Rapid Onset of Retinal Toxicity From High-Dose Hydroxychloroquine Given for Cancer Therapy

(2015) Loh-Shan B. Leung et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells

(2015) Shohei Sugita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy inhibitors

(2015) Benoit Pasquier   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting autophagy to overcome drug resistance in cancer therapy

(2015) Ankit Kumar et al.   Future Medicinal Chemistry

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(2015) Emma Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs

(2015) Asuka Nakata et al.   Scientific Reports

Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress

(2015) Wei-Jiunn Lee et al.   Scientific Reports

Co-delivery of Gefitinib and chloroquine by chitosan nanoparticles for overcoming the drug acquired resistance

(2015) Liang Zhao et al.   JOURNAL OF NANOBIOTECHNOLOGY

Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells

(2015) Mei-Chuan Tang et al.   PLoS One

Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs

(2014) Daisuke Hashimoto et al.   EUROPEAN JOURNAL OF CANCER

The Regulation of the Autophagic Network and Its Implications for Human Disease

(2014) Jing Yang et al.   International Journal of Biological Sciences

ERK1/2 activity contributes to gemcitabine resistance in pancreatic cancer cells

(2013) Chunning Zheng et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib

(2013) Yiyu Zou et al.   Journal of Thoracic Oncology

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Gemcitabine Plus Erlotinib for Advanced Pancreatic Cancer: A Systematic Review with Meta-Analysis

(2013) Zu-Yao Yang et al.   PLoS One

β-Catenin overexpression is associated with gefitinib resistance in non-small cell lung cancer cells

(2013) Xia Fang et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

The Autophagy Inhibitor Verteporfin Moderately Enhances the Antitumor Activity of Gemcitabine in a Pancreatic Ductal Adenocarcinoma Model

(2013) Elizabeth Donohue et al.   Journal of Cancer

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Targeting EGFR in Pancreatic Cancer Treatment

(2012) T. Troiani et al.   CURRENT DRUG TARGETS

Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma

(2012) Dong Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

(2011) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

(2011) Weidong Han et al.   PLoS One

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

(2010) Sarah F. Funderburk et al.   TRENDS IN CELL BIOLOGY