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Pharmacology & Pharmacy
Kinga Molnar, Balint Lorinczi, Csilla Fazakas, Istvan Szatmari, Ferenc Fulop, Noemi Kmetyko, Robert Berkecz, Istvan Ilisz, Istvan A. Krizbai, Imola Wilhelm, Laszlo Vecsei
Summary: The study synthesized six novel aminoalkylated amide derivatives of kynurenic acid, with SZR-104 showing the highest permeability through the blood-brain barrier. Compared to kynurenic acid, xanthurenic acid, and 39B, SZR-104 demonstrated significantly higher penetrability and potential to inhibit epileptiform activity in the brain.
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Cardiac & Cardiovascular Systems
Adam Nyul-Toth, Stefano Tarantini, Jordan DelFavero, Feng Yan, Priya Balasubramanian, Andriy Yabluchanskiy, Chetan Ahire, Tamas Kiss, Tamas Csipo, Agnes Lipecz, Attila E. Farkas, Imola Wilhelm, Istvan A. Krizbai, Qinggong Tang, Anna Csiszar, Zoltan Ungvari
Summary: Age-related blood-brain barrier disruption and cerebromicrovascular rarefaction play important roles in the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). Recent advances in geroscience research have provided new interventions for preventing these diseases. Sensitive and easy-to-adapt imaging methods are urgently needed for longitudinal assessment of changes in BBB permeability and brain capillarization in aged mice.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
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Oncology
Ines Figueira, Sofia Galego, Tania Custodio-Santos, Raquel Vicente, Kinga Molnar, Janos Hasko, Rui Malho, Mafalda Videira, Imola Wilhelm, Istvan Krizbai, Maria Alexandra Brito
Summary: Breast cancer brain metastasis is a life-threatening condition with poor survival rates. Through microscopic analysis in a mouse model, potential therapeutic targets have been identified for this disease.
Article
Biophysics
Csilla Fazakas, Mihaly Kozma, Kinga Molnar, Andras Kincses, Andras Der, Adrienn Fejer, Barnabas Horvath, Imola Wilhelm, Istvan A. Krizbai, Attila G. Vegh
Summary: Brain metastases are a feared complication of cancer, with breast adenocarcinoma being one of the leading sources. Research shows that exosomes derived from breast adenocarcinoma can affect the adhesion strength between cancer cells and brain endothelium.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
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Biochemistry & Molecular Biology
Mihaly Kozma, Adam Meszaros, Adam Nyul-Toth, Kinga Molnar, Laura Costea, Zsofia Hernadi, Csilla Fazakas, Attila E. Farkas, Imola Wilhelm, Istvan A. Krizbai
Summary: Cells in the neurovascular unit actively participate in neuroinflammatory reactions by upregulating cell adhesion molecules and secreting proinflammatory cytokines. Both pericytes and endothelial cells can activate inflammasomes, with the noncanonical pathway being demonstrated in both types of cells. This activation leads to increased secretion of interleukin-1 beta and disruption of tight junctions. Overall, mutual activation of pericytes and endothelial cells occurs in inflammation, with inflammatory responses and barrier properties being affected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
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Endocrinology & Metabolism
Akos Menyhart, Rita Frank, Attila E. Farkas, Zoltan Sule, Viktoria E. Varga, Adam Nyul-Toth, Anne Meiller, Orsolya Ivankovits-Kiss, Coline L. Lemale, Irisz Szabo, Reka Toth, Daniel Zolei-Szenasi, Johannes Woitzik, Stephane Marinesco, Istvan A. Krizbai, Ferenc Bari, Jens P. Dreier, Eszter Farkas
Summary: Acute brain swelling impairs astroglial glutamate clearance and leads to extracellular glutamate accumulation and the occurrence of SiD, a pathological spreading depolarization associated with astrocyte swelling and neuronal death. Preventive osmotherapy may be necessary in acute brain injury to mitigate the effects of SiD.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Irisz Szabo, Viktoria E. Varga, Szabolcs Dvoracsko, Attila E. Farkas, Timea Kormoczi, Robert Berkecz, Szilvia Kecskes, Akos Menyhart, Rita Frank, Dora Hantosi, Nicholas V. Cozzi, Ede Frecska, Csaba Tomboly, Istvan A. Krizbai, Ferenc Bari, Eszter Farkas
Summary: The study suggests that DMT may serve as an adjuvant pharmacological therapy in the management of acute cerebral ischemia, by mitigating spreading depolarizations (SDs) and promoting neuronal survival, reducing the number of apoptotic and ferroptotic cells.
Article
Biochemistry & Molecular Biology
Tamas F. Polgar, Valeria Meszlenyi, Bernat Nogradi, Laura Kormoczy, Krisztina Spisak, Kornelia Tripolszki, Marta Szell, Izabella Obal, Jozsef I. Engelhardt, Laszlo Siklos, Roland Patai
Summary: The injection of blood sera from ALS patients led to degeneration of motor neurons in mice, with the severity of degeneration varying depending on the type of mutation. Mutations in the chromosome 9 open reading frame 72 gene resulted in the most significant degenerative effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kinga Molnar, Bernat Nogradi, Rebeka Kristof, Adam Meszaros, Krisztian Pajer, Laszlo Siklos, Antal Nogradi, Imola Wilhelm, Istvan A. Krizbai
Summary: In peripheral nerve injury, the activation of inflammasomes in motor neurons of the spinal cord triggers an inflammatory reaction and activates microglia. Inhibition of neuronal inflammasome activation not only reduces microglia response significantly but also has a beneficial effect on nerve regeneration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Anett Hudak, Gareth Morgan, Jaromir Bacovsky, Roland Patai, Tamas F. Polgar, Annamaria Letoha, Aladar Pettko-Szandtner, Csaba Vizler, Laszlo Szilak, Tamas Letoha
Summary: This study reveals that in addition to the human ACE2 receptor, SARS-CoV-2 can also enter cells through the syndecan-4 protein of mice, leading to uptake in various organs and the onset of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Reynald Thinard, Attila E. Farkas, Marta Halasa, Melanie Chevalier, Klaudia Brodaczewska, Aleksandra Majewska, Robert Zdanowski, Maria Paprocka, Joanna Rossowska, Lam Tri Duc, Ruth Greferath, Istvan Krizbai, Fred Van Leuven, Claudine Kieda, Claude Nicolau
Summary: This study developed a novel approach to facilitate the penetration of antibody fragments into the brain parenchyma by leveraging the homing properties of endothelial progenitor cells. The results showed that the production and secretion of antibody fragments at the blood-brain barrier level could lead to their migration to the brain parenchyma where they might exert a therapeutic effect.
Article
Biochemistry & Molecular Biology
Nora Torok, Rita Maszlag-Torok, Kinga Molnar, Zoltan Szolnoki, Ferenc Somogyvari, Krisztina Boda, Masaru Tanaka, Peter Klivenyi, Laszlo Vecsei
Summary: This study found that SNPs in the IDO1 gene may influence the age of onset of Parkinson's disease, and genotyping of SNPs in certain alleles potentially serves as a risk biomarker for Parkinson's disease.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)