Article
Oncology
Mingying Ling, Congmin Tang, Xuechun Yang, Na Yu, Yiping Song, Wenjing Ding, Yan Sun, Rong Yan, Shaopeng Wang, Xuehui Li, Haiqing Gao, Zhen Zhang, Yanqiu Xing
Summary: This study aimed to investigate the effects and underlying mechanisms of exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-exos) on aging livers. Results showed that hUCMSC-exos improved structural disorder and decreased senescence markers and genome instability in aging livers. Metabolomics and phosphoproteomics analyses revealed that hUCMSC-exos regulated lipid metabolism and phosphorylation levels of proteins involved in various cellular processes. Overall, hUCMSC-exos improved metabolic reprogramming and genome stability in aging livers, providing a basis for future research on the application of hUCMSC-exos in aging.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Zilong Zhang, Jin Shang, Qinyan Yang, Zonglin Dai, Yuxin Liang, Chunyou Lai, Tianhang Feng, Deyuan Zhong, Haibo Zou, Lelin Sun, Yuhao Su, Su Yan, Jie Chen, Yutong Yao, Ying Shi, Xiaolun Huang
Summary: This study suggests that exosomes derived from human adipose mesenchymal stem cells (hADMSCs-Exo) have significant therapeutic effects on liver fibrosis and cirrhosis. The researchers found that hADMSCs-Exo can inhibit the proliferation of activated hepatic stellate cells, effectively suppress the expression of profibrogenic proteins and epithelial-to-mesenchymal transition (EMT), and improve liver function and reduce liver inflammation. The key mechanism of hADMSCs-Exo in anti-hepatic fibrosis is the inhibition of the PI3K/AKT/mTOR signaling pathway and the regulation of choline metabolism.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ming-ying Ling, Xue-chun Yang, Na Yu, Yi-ping Song, Yu-jing Zheng, Cong-min Tang, Wen-jing Ding, Yan Sun, Rong Yan, Shao-peng Wang, Xue-hui Li, Hai-qing Gao, Zhen Zhang, Yan-qiu Xing
Summary: This study investigates the role of exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs-exos) in treating diabetic cardiovascular complications. Through various techniques, it was found that exosomes can reverse the abnormalities in certain metabolites in diabetic arteries, and influence multiple protein pathways related to vascular remodeling, mainly involving energy metabolism, oxidative stress, inflammation, and cellular communications.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Cell Biology
Daniela S. C. Bispo, Lenka Michalkova, Marlene Correia, Catarina S. H. Jesus, Iola F. Duarte, Brian J. Goodfellow, Mariana B. Oliveira, Joao F. Mano, Ana M. Gil
Summary: This study provides the first comprehensive characterization of the lipidome and exometabolome during osteogenic differentiation of human adipose tissue stem cells (hAMSCs) using NMR spectroscopy. Lipid changes primarily occur between days 1 and 7, followed by stabilization. The findings shed light on the mechanisms involved in membrane remodeling, antioxidant defense, protein synthesis, and energy metabolism during hAMSC osteogenic differentiation.
Review
Cell & Tissue Engineering
Yuxiang Zhang, Wei Ju, Hong Zhang, Liu Mengyun, Weiliang Shen, Xiao Chen
Summary: Tendinopathy is a disease caused by the degeneration of tendon tissue, and currently, there is no treatment available to prevent or delay its progression. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may be useful for promoting tendon healing and could be considered as a potential treatment for tendinopathy.
STEM CELL RESEARCH & THERAPY
(2023)
Retraction
Cell & Tissue Engineering
Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang, Xuexi Wang
Summary: The article has been retracted. More details can be found in the Retraction Notice at https://doi.org/10.1186/s13287-019-1149-5.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell & Tissue Engineering
Yao Sun, Guoliang Liu, Kai Zhang, Qian Cao, Tongjun Liu, Jiannan Li
Summary: Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. Researchers have increasingly focused on using exosomes for drug delivery, especially MSC-EXOs, due to their immune properties, tumor-homing properties, and elastic properties. This review article summarizes the characteristics of MSC-EXOs and introduces production, purification, and drug loading methods to address existing problems and provide suggestions for future studies.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Nesrine Ebrahim, Heba Elsayed Abd El-Halim, Omayma Kamel Helal, Nahla El-Eraky El-Azab, Omnia A. M. Badr, Amira Hassouna, Hajir A. Al Saihati, Nashwa Hassan Aborayah, Hanan Tawfeek Emam, Hend S. El-wakeel, Mohammad Aljasir, Mohamed El-Sherbiny, Naglaa A. S. Sarg, Gehan Ahmed Shaker, Ola Mostafa, Dina Sabry, Marwa Abdel Kader Fouly, Nicholas Robert Forsyth, Nehal M. Elsherbiny, Rabab F. Salim
Summary: The study indicated that BM-MSCs-Ex reduced oxidative stress, inflammation, and angiogenesis in diabetic retinas by inhibiting the Wnt/β-catenin signaling pathway, ultimately improving DR features.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Naina Soni, Suchi Gupta, Surender Rawat, Vishnu Krishnakumar, Sujata Mohanty, Arup Banerjee
Summary: This study investigates the effects of exosomes derived from different sources on immune cells. The expression levels of miRNAs varied within different MSCs and exosomes, and most miRNAs had expression profiles different from their respective sources. Exosomes from different sources had different abilities to induce neurogenesis and angiogenesis, as well as varying effects on PBMC proliferation, neutrophil survival, and NET formation.
Review
Cell & Tissue Engineering
Jian-feng Zhou, Yu Xiong, Xiaodong Kang, Zhigang Pan, Qiangbin Zhu, Roland Goldbrunner, Lampis Stavrinou, Shu Lin, Weipeng Hu, Feng Zheng, Pantelis Stavrinou
Summary: Intracerebral hemorrhage is a highly destructive brain disease with main risk factors such as hypertension and drug abuse. Stem cells and exosomes are considered as new methods for treatment, but more clinical studies are needed to confirm their safety and efficacy.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Alfonso Eirin, Yu Meng, Xiang-Yang Zhu, Yongxin Li, Ishran M. Saadiq, Kyra L. Jordan, Hui Tang, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Summary: Obesity alters the miRNA expression profile and size of human adipose mesenchymal stem/stromal cell-derived extracellular vesicles (EVs), reducing their capacity to repair injured cells and modulate important injury pathways in recipient cells. These observations may guide the development of novel strategies to improve healing and repair in obese individuals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Song Peng, Chang Sun, Chengteng Lai, Lei Zhang
Summary: The study evaluated the potential pro-inflammatory effects and molecular mechanism of MSC-Exos in Osteoarthritis. MSC-Exos improved osteoarthritis by reducing inflammation levels, preventing ferroptosis, and inducing expression of GOT1/CCR2 to regulate ferroptosis. In addition, MSC-Exos promoted cell growth and osteogenic differentiation in an in vitro model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Mehrdad Hajinejad, Sajad Sahab-Negah
Summary: Neuroinflammation plays a crucial role in neurological disorders, and mesenchymal stem cells can modulate inflammation and microglia/macrophage polarization through exosome secretion. Studies have shown that miRNAs contained in exosomes have the potential to impact recipient cell behavior, providing a novel therapeutic approach for addressing inflammatory pathways in neurological diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jiawei Zhao, Yue Li, Rongrong Jia, Jinghui Wang, Min Shi, Yugang Wang
Summary: Exosomes, particularly Exo@DEX, have shown promising potential as a drug carrier for autoimmune hepatitis (AIH) by efficiently improving the accumulation of dexamethasone (DEX) in the liver, suggesting potential applications in other diseases as well.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
Alvin K. Shieh, Sohni G. Singh, Connor Nathe, Evan Lian, Dominik R. Haudenschild, Jan A. Nolta, Cassandra A. Lee, Eric Giza, Christopher D. Kreulen
Article
Cell & Tissue Engineering
Oliver Yuan, Clayton Lin, Joseph Wagner, Joehleen A. Archard, Peter Deng, Julian Halmai, Gerhard Bauer, Kyle D. Fink, Brian Fury, Nicholas H. Perotti, Jon E. Walker, Kari Pollock, Michelle Apperson, Janelle Butters, Peter Belafsky, D. Gregory Farwell, Maggie Kuhn, Jan Nolta, Johnathon D. Anderson
STEM CELLS AND DEVELOPMENT
(2019)
Review
Cell & Tissue Engineering
Fanny M. Elahi, D. Gregory Farwell, Jan A. Nolta, Johnathon D. Anderson
Article
Cell & Tissue Engineering
Jan A. Nolta, Jacques Galipeau, Donald G. Phinney
Article
Biochemistry & Molecular Biology
Julian A. N. M. Halmai, Peter Deng, Casiana E. Gonzalez, Nicole B. Coggins, David Cameron, Jasmine L. Carter, Fiona K. B. Buchanan, Jennifer J. Waldo, Samantha R. Lock, Johnathon D. Anderson, Henriette O'Geen, David J. Segal, Jan Nolta, Kyle D. Fink
NUCLEIC ACIDS RESEARCH
(2020)
Editorial Material
Cell & Tissue Engineering
Jan A. Nolta
Article
Cell & Tissue Engineering
Shannon M. Clayton, Joehleen A. Archard, Joseph Wagner, D. Gregory Farwell, Arnaud F. Bewley, Angela Beliveau, Andrew Birkeland, Shyam Rao, Marianne Abouyared, Peter C. Belafsky, Johnathon D. Anderson
STEM CELLS AND DEVELOPMENT
(2020)
Article
Cell & Tissue Engineering
Verena Boerger, Daniel J. Weiss, Johnathon D. Anderson, Francesc E. Borras, Benedetta Bussolati, David R. F. Carter, Massimo Dominici, Juan M. Falcon-Perez, Mario Gimona, Andrew F. Hill, Andrew M. Hoffman, Dominique de Kleijn, Bruce L. Levine, Rebecca Lim, Jan Lotvall, S. Alex Mitsialis, Marta Monguio-Tortajada, Maurizio Muraca, Rienk Nieuwland, Anna Nowocin, Lorraine O'Driscoll, Luis A. Ortiz, Donald G. Phinney, Ilona Reischl, Eva Rohde, Ralf Sanzenbacher, Clotilde Thery, Wei Seong Toh, Kenneth W. Witwer, Sai Kiang Lim, Bernd Giebel
Article
Medicine, Research & Experimental
Nogah Nativ-Zeltzer, Rumi Ueha, Yuval Nachalon, Betty Ma, Gabrielle Pastenkos, Clay Swackhamer, Gail M. Bornhorst, Maureen A. Lefton-Greif, Johnathon D. Anderson, Peter C. Belafsky
Summary: The study found that recurrent aspiration of small amounts of thickened water resulted in significant pulmonary inflammation in a murine model of aspiration, supporting the need for further investigation of liquid thickener safety and its efficacy in reducing the pulmonary complications of swallowing disorders.
Review
Cardiac & Cardiovascular Systems
Yun Lin, Johnathon D. Anderson, Lily M. A. Rahnama, Shenwen Gu, Anne A. Knowlton
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Editorial Material
Cell & Tissue Engineering
Jan A. Nolta
Article
Cell & Tissue Engineering
Guido Moll, James A. Ankrum, Scott D. Olson, Jan A. Nolta
Summary: The number and types of mesenchymal stromal/stem cell (MSC) therapeutics and clinical applications have greatly increased, but there is also a risk of poorly regulated Stem Cell Clinics offering unproven interventions. It is important to critically evaluate the identity and suitability of MSC products for safe intravascular administration.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Brian C. DeFelice, Oliver Fiehn, Peter Belafsky, Constanze Ditterich, Michael Moore, Marianne Abouyared, Angela M. Beliveau, D. Gregory Farwell, Arnaud F. Bewley, Shannon M. Clayton, Joehleen A. Archard, Jordan Pavlic, Shyam Rao, Maggie Kuhn, Peter Deng, Julian Halmai, Kyle D. Fink, Andrew C. Birkeland, Johnathon D. Anderson
Summary: This study found significant differences in the concentration of polyamine metabolites in the urine of head and neck cancer patients compared to healthy controls, with only one polyamine metabolite detected at elevated levels in the saliva of patients. These findings suggest that assessing polyamine-based metabolite biomarkers in saliva and urine may have potential as a diagnostic tool for head and neck cancer, but further research is necessary.
Editorial Material
Cell & Tissue Engineering
Daniel J. Weiss, Anthony Filiano, Jacques Galipeau, Maroun Khoury, Mauro Krampera, Manoj Lalu, Katarina Le Blanc, Jan Nolta, Donald G. Phinney, Patricia R. M. Rocco, Yufang Shi, Karin Tarte, Sowmya Viswanathan, Ivan Martin
Editorial Material
Cell & Tissue Engineering
Johnathon D. Anderson
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)