Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes

Optical imaging of glucose uptake and mitochondrial membrane potential to characterize Her2 breast tumor metabolic phenotypes

(2019) Megan C Madonna et al.   MOLECULAR CANCER RESEARCH

Low dose photodynamic therapy harmonizes with radiation therapy to induce beneficial effects on pancreatic heterocellular spheroids

(2019) Anne-Laure Bulin et al.   Oncotarget

Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer

(2019) Mans Broekgaarden et al.   BIOMATERIALS

Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors

(2018) Wenyun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids

(2018) Mans Broekgaarden et al.   Oncotarget

A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds

(2018) Balaraman Kalyanaraman et al.   Redox Biology

Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids

(2017) Anne-Laure Bulin et al.   Scientific Reports

The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI

(2017) Sandro Goruppi et al.   Cell Reports

Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism

(2017) Balaraman Kalyanaraman   Redox Biology

Metabolic Profiling of healthy and cancerous tissues in 2D and 3D

(2017) Shonagh Russell et al.   Scientific Reports

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis

(2016) Camille Lehuédé et al.   CANCER RESEARCH

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Imaging metabolic heterogeneity in cancer

(2016) Debanti Sengupta et al.   Molecular Cancer

Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes

(2016) Mans Broekgaarden et al.   Nano Research

Photonanomedicine: a convergence of photodynamic therapy and nanotechnology

(2016) Girgis Obaid et al.   Nanoscale

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response

(2016) Alex J. Walsh et al.   PANCREAS

Measurements of absolute concentrations of NADH in cells using the phasor FLIM method

(2016) Ning Ma et al.   Biomedical Optics Express

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

(2016) Erik S. Knudsen et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies

(2015) Mans Broekgaarden et al.   CANCER AND METASTASIS REVIEWS

Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer

(2015) H.-C. Huang et al.   CANCER RESEARCH

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Erratum: Corrigendum: Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

(2015) Maria-Giuseppina Procopio et al.   NATURE CELL BIOLOGY

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors

(2015) Anneleen Daemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up

(2015) R. M. Perera et al.   Cancer Discovery

Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer

(2014) M T Huggett et al.   BRITISH JOURNAL OF CANCER

Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer

(2014) A. J. Walsh et al.   CANCER RESEARCH

Endogenous Two-Photon Fluorescence Imaging Elucidates Metabolic Changes Related to Enhanced Glycolysis and Glutamine Consumption in Precancerous Epithelial Tissues

(2014) A. Varone et al.   CANCER RESEARCH

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models

(2014) Jonathan P. Celli et al.   Scientific Reports

Non-invasive monitoring of cell metabolism and lipid production in 3D engineered human adipose tissues using label-free multiphoton microscopy

(2013) Tyler Chang et al.   BIOMATERIALS

Optical Metabolic Imaging Identifies Glycolytic Levels, Subtypes, and Early-Treatment Response in Breast Cancer

(2013) A. J. Walsh et al.   CANCER RESEARCH

Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation

(2013) Kyle P. Quinn et al.   Scientific Reports

Optical Imaging Using Endogenous Contrast to Assess Metabolic State

(2012) Irene Georgakoudi et al.   Annual Review of Biomedical Engineering

Ex vivooptical metabolic measurements from cultured tissue reflectin vivotissue status

(2012) Alex J. Walsh et al.   JOURNAL OF BIOMEDICAL OPTICS

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ki-67 as a Molecular Target for Therapy in an In vitro Three-Dimensional Model for Ovarian Cancer

(2010) R. Rahmanzadeh et al.   CANCER RESEARCH

Synergistic Enhancement of Carboplatin Efficacy with Photodynamic Therapy in a Three-Dimensional Model for Micrometastatic Ovarian Cancer

(2010) I. Rizvi et al.   CANCER RESEARCH

Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization

(2010) Jonathan P. Celli et al.   CHEMICAL REVIEWS

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Two-Photon Microscopy for Non-Invasive, Quantitative Monitoring of Stem Cell Differentiation

(2010) William L. Rice et al.   PLoS One