ER-localized Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection

Phospholipid transport protein function at organelle contact sites

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Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

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Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3

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Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases

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Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

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An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Cellular and molecular regulation of innate inflammatory responses

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USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation

(2016) Sabrina Torre et al.   NATURE IMMUNOLOGY

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

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Structure and function of ER membrane contact sites with other organelles

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The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

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Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

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USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

(2014) Qiang Zou et al.   NATURE IMMUNOLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

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TRAF5 Negatively Regulates TLR Signaling in B Lymphocytes

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

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Endoplasmic reticulum–mitochondria contacts: function of the junction

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Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria

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Structural variability of the ubiquitin specific protease DUSP-UBL double domains

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USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

The ER in 3D: a multifunctional dynamic membrane network

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Expanding role of ubiquitination in NF-κB signaling

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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Intrinsic Conformational Determinants Signal Protein Misfolding to the Hrd1/Htm1 Endoplasmic Reticulum–associated Degradation System

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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