Fabrication of a Zn(II)-Based 2D Pillar Bilayer Metal-Organic Framework for Antimicrobial Activity

A Zn(II)-based two-dimensional (2D) pillar bilayer metal-organic framework (MOF) [{Zn(aip)(4,4 '-bpy)(0.5)(MeOH)}(H2O)](n) (1), (H(2)aip=5-aminoisophthalic acid and 4,4 '-bpy=4, 4 '-bipyridine) has been designed and structurally characterized by single crystal X-ray diffraction (SCXRD) technique. Compound 1 exhibits considerable antibacterial activity upon Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), for which IC50 values have been obtained as 86.26 +/- 1.2 mu g/ml and 95.96 +/- 2.04 mu g/ml respectively. Thus the fabricated MOF has the significant antibacterial property against pathogenic bacterial strains with significantly low IC50 values. Therefore, the compound 1 deserves to be a Bio-MOF in the world of hybrid materials.