Journal
CHEMISTRYSELECT
Volume 4, Issue 33, Pages 9726-9730Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201902039
Keywords
Liposomes; Multidrug resistant tuberculosis; Mycobacterium tuberculosis; Photodynamic antimicrobial chemotherapy; Zn phthalocyanine
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Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) of Argentina
- SECYT UNC
- FONCYT
- CONICET
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Tuberculosis is one of the most important global health problems. Multidrug resistant (MDR)-tuberculosis is caused by Mycobacterium tuberculosis (M. tuberculosis) resistant to the first line drugs (rifampin-isoniazid). Photodynamic antimicrobial chemotherapy (PACT) has reemerged as an alternative against resistant bacteria. In this work, we synthetized liposomes of Dipalmitoylphosphatidylcholine and Cholesterol as carrier of ZnPc. The ZnPc-liposomes photodynamic activity was tested in two strains of M. tuberculosis, a sensible (ATCC 27294) and MDR-M. tuberculosis. As result, both strains were inactivated by ZnPc-liposomes. The photodynamic activity was dependent of incubation time and light dose supplied. The photokilling activity was considerably higher for sensible strain than for MDR one.
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