Iron-sulfur clusters in mitochondrial metabolism: Multifaceted roles of a simple cofactor

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

(2016) Nunziata Maio et al.   Cell Metabolism

Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster

(2016) Marie-Pierre Golinelli-Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure of aconitase to smoking-related oxidants results in iron loss and increased iron response protein-1 activity: potential mechanisms for iron accumulation in human arterial cells

(2016) Jihan Talib et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The Human Iron–Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules

(2015) Nicholas G. Fox et al.   BIOCHEMISTRY

Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe–S Assembly Complex

(2015) Nicholas G. Fox et al.   BIOCHEMISTRY

Very long chain ceramides interfere with C16-ceramide-induced channel formation: A plausible mechanism for regulating the initiation of intrinsic apoptosis

(2015) Johnny Stiban et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Emerging critical roles of Fe–S clusters in DNA replication and repair

(2015) Jill O. Fuss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biogenesis of cytosolic and nuclear iron–sulfur proteins and their role in genome stability

(2015) Viktoria Désirée Paul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron –sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery

(2015) Nunziata Maio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure–function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease

(2015) Sagi Tamir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability

(2015) Prasenjit Prasad Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Disease-related Mutation G167P in CytochromebofRhodobacter capsulatusCytochromebc1(S151P in Human) Affects the Equilibrium Distribution of [2Fe-2S] Cluster and Generation of Superoxide

(2015) Arkadiusz Borek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis

(2015) Colin H. Lipper et al.   PLoS One

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I

(2015) Katarzyna Kmita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of ceramide channel formation and disassembly: Insights on the initiation of apoptosis

(2015) Majdouline Abou-Ghali et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry

(2014) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Mammalian Fe–S cluster biogenesis and its implication in disease

(2014) Lena K. Beilschmidt et al.   BIOCHIMIE

Mitochondrial iron–sulfur protein biogenesis and human disease

(2014) Oliver Stehling et al.   BIOCHIMIE

Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery

(2014) Nunziata Maio et al.   Cell Metabolism

Protein-mediated assembly of succinate dehydrogenase and its cofactors

(2014) Jonathan G. Van Vranken et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron

(2014) Rina Shimizu et al.   GENE

Roles of semiquinone species in proton pumping mechanism by complex I

(2014) Eiko Nakamaru-Ogiso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The N-terminal Domain of theDrosophilaMitochondrial Replicative DNA Helicase Contains an Iron-Sulfur Cluster and Binds DNA

(2014) Johnny Stiban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Control of Human Mitochondrial Outer Membrane Protein MitoNEET [2Fe-2S] Clusters by Biological Thiols and Hydrogen Peroxide

(2014) Aaron P. Landry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Function of the Fanconi Anemia Group J or RECQ1 Helicase to Disrupt Protein-DNA Complexes in a Replication Protein A-stimulated Manner

(2014) Joshua A. Sommers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Diabetes Drug Target MitoNEET Governs a Novel Trafficking Pathway to Rebuild an Fe-S Cluster into Cytosolic Aconitase/Iron Regulatory Protein 1

(2014) Ioana Ferecatu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ISCA2mutation causes infantile neurodegenerative mitochondrial disorder

(2014) Zuhair N Al-Hassnan et al.   JOURNAL OF MEDICAL GENETICS

The CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity

(2014) Sofia Lemak et al.   NUCLEIC ACIDS RESEARCH

Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control

(2014) Caiguo Zhang   Protein & Cell

Protein conformational changes involved in the cytochrome bc1 complex catalytic cycle

(2013) Jason W. Cooley   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Unanswered questions about the structure of cytochrome bc1 complexes

(2013) Edward A. Berry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

CIAPIN1 siRNA Inhibits Proliferation, Migration and Promotes Apoptosis of VSMCs by Regulating Bcl-2 and Bax

(2013) Zhao Yang et al.   CURRENT NEUROVASCULAR RESEARCH

Mutations in LYRM4, encoding iron–sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes

(2013) Sze Chern Lim et al.   HUMAN MOLECULAR GENETICS

WhiB7, an Fe-S-dependent Transcription Factor That Activates Species-specific Repertoires of Drug Resistance Determinants in Actinobacteria

(2013) Santiago Ramón-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human anamorsin binds [2Fe–2S] clusters with unique electronic properties

(2013) Lucia Banci et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mitoneet mediates TNFα-induced necroptosis promoted by exposure to fructose and ethanol

(2013) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

An Iron–Sulfur Cluster in the Polymerase Domain of Yeast DNA Polymerase ε

(2013) Rinku Jain et al.   JOURNAL OF MOLECULAR BIOLOGY

Toroidal Structure and DNA Cleavage by the CRISPR-Associated [4Fe-4S] Cluster Containing Cas4 Nuclease SSO0001 from Sulfolobus solfataricus

(2013) Sofia Lemak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

(2013) Yang-Sung Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural analysis of cytochrome bc1 complexes: Implications to the mechanism of function

(2012) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells

(2012) Ester Sánchez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Catalytic mechanisms of complex II enzymes: A structural perspective

(2012) T.M. Iverson   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

(2012) Roland Lill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

(2012) T. A. Rouault   Disease Models & Mechanisms

Identification and Biochemical Characterization of a Novel Mutation inDDX11Causing Warsaw Breakage Syndrome

(2012) José-Mario Capo-Chichi et al.   HUMAN MUTATION

Human Exonuclease 5 Is a Novel Sliding Exonuclease Required for Genome Stability

(2012) Justin L. Sparks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

(2012) Christine M Kusminski et al.   NATURE MEDICINE

Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron–sulfur cluster domain

(2012) Subhash Pokharel et al.   NUCLEIC ACIDS RESEARCH

DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster

(2012) Y. Wu et al.   NUCLEIC ACIDS RESEARCH

The CRISPR Associated Protein Cas4 Is a 5′ to 3′ DNA Exonuclease with an Iron-Sulfur Cluster

(2012) Jing Zhang et al.   PLoS One

Structure–Function Analysis of Friedreich’s Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe–S Assembly Complex

(2011) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis

(2011) Yanbo Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

Iron–sulphur clusters in nucleic acid processing enzymes

(2011) Malcolm F White et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex

(2011) Stéphane Schmucker et al.   PLoS One

Human Frataxin Is an Allosteric Switch That Activates the Fe−S Cluster Biosynthetic Complex

(2010) Chi-Lin Tsai et al.   BIOCHEMISTRY

Quinone binding and reduction by respiratory complex I

(2010) Maja A. Tocilescu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The role of a conserved tyrosine in the 49-kDa subunit of complex I for ubiquinone binding and reduction

(2010) Maja A. Tocilescu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes

(2010) Y. Wu et al.   BLOOD

Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

(2010) Young-Hoon Kang et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

(2010) Mohamed Atta et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The pro-oxidant chromium(VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe–S proteins

(2010) Charles R. Myers et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron–sulfur cluster biogenesis

(2010) Helge Uhrigshardt et al.   HUMAN MOLECULAR GENETICS

Metabolic Response to Iron Deficiency in Saccharomyces cerevisiae

(2010) Minoo Shakoury-Elizeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frataxin and Mitochondrial FeS Cluster Biogenesis

(2010) Timothy L. Stemmler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-Mediated Charge Transport in Redox Sensing and Signaling

(2010) Joseph C. Genereux et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Yeast Exonuclease 5 Is Essential for Mitochondrial Genome Maintenance

(2010) P. M. Burgers et al.   MOLECULAR AND CELLULAR BIOLOGY

Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis

(2010) Daili J A Netz et al.   Nature Chemical Biology

Electron tunneling in respiratory complex I

(2010) T. Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions

(2010) Rong Shi et al.   PLOS BIOLOGY

Structure, function and evolution of the XPD family of iron–sulfur-containing 5′→3′ DNA helicases

(2009) Malcolm F. White   BIOCHEMICAL SOCIETY TRANSACTIONS

Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis

(2009) Y. Shi et al.   HUMAN MOLECULAR GENETICS

An Iron-Sulfur Cluster Is Essential for the Binding of Broken DNA by AddAB-type Helicase-Nucleases

(2009) Joseph T. P. Yeeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

(2009) J. P. Duxin et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Ind1, an Iron-Sulfur Cluster Assembly Factor for Respiratory Complex I

(2009) A. D. Sheftel et al.   MOLECULAR AND CELLULAR BIOLOGY

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Iron–sulfur cluster biosynthesis

(2008) Sibali Bandyopadhyay et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure of the DNA Repair Helicase XPD

(2008) Huanting Liu et al.   CELL

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

(2008) Li Fan et al.   CELL

The iron–sulphur protein Ind1 is required for effective complex I assembly

(2008) Katrine Bych et al.   EMBO JOURNAL

Redox Control of the DNA Damage-inducible Protein DinG Helicase Activity via Its Iron-Sulfur Cluster

(2008) Binbin Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interrelationship of Helicase and Nuclease Domains during DNA Translocation by the Molecular Motor EcoR124I

(2008) Eva Šišáková et al.   JOURNAL OF MOLECULAR BIOLOGY

Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

(2008) Li Zheng et al.   MOLECULAR CELL

In vivo iron-sulfur cluster formation

(2008) E. C. Raulfs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the FeS Cluster–Containing Nucleotide Excision Repair Helicase XPD

(2008) Stefanie C Wolski et al.   PLOS BIOLOGY