Control of myofibroblast differentiation and function by cytoskeletal signaling

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen

(2016) Yujie Zhang et al.   Scientific Reports

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

(2015) Thomas H. Sisson et al.   AMERICAN JOURNAL OF PATHOLOGY

Myofibroblasts Exhibit Enhanced Fibronectin Assembly That Is Intrinsic to Their Contractile Phenotype

(2015) Elizabeth E. Torr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vimentin regulates activation of the NLRP3 inflammasome

(2015) Gimena dos Santos et al.   Nature Communications

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Control of Myofibroblast Differentiation by Microtubule Dynamics through a Regulated Localization of mDia2

(2013) Nathan Sandbo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

(2013) Yong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Murine Colitis is Mediated by Vimentin

(2013) Nirit Mor-Vaknin et al.   Scientific Reports

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair

(2012) C. G. Elliott et al.   JOURNAL OF CELL SCIENCE

Microtubules regulate GEF-H1 in response to extracellular matrix stiffness

(2012) Jessica N. Heck et al.   MOLECULAR BIOLOGY OF THE CELL

Withaferin-A Reduces Type I Collagen Expression In Vitro and Inhibits Development of Myocardial Fibrosis In Vivo

(2012) Azariyas A. Challa et al.   PLoS One

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

(2011) Leticia Sansores-Garcia et al.   EMBO JOURNAL

A Novel Role of Vimentin Filaments: Binding and Stabilization of Collagen mRNAs

(2011) A. A. Challa et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules

(2011) Jeremie Gaillard et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Linking cell structure to gene regulation: Signaling events and expression controls on the model genes PAI-1 and CTGF

(2010) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

The actin gene family: Function follows isoform

(2010) Benjamin J. Perrin et al.   Cytoskeleton

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

The RhoA Activator GEF-H1/Lfc Is a Transforming Growth Factor-β Target Gene and Effector That Regulates α-Smooth Muscle Actin Expression and Cell Migration

(2010) Anna Tsapara et al.   MOLECULAR BIOLOGY OF THE CELL

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P3 Axis

(2010) Francesca Cencetti et al.   MOLECULAR BIOLOGY OF THE CELL

Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

(2009) Nathan Sandbo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Binding of LARP6 to the Conserved 5′ Stem–Loop Regulates Translation of mRNAs Encoding Type I Collagen

(2009) Le Cai et al.   JOURNAL OF MOLECULAR BIOLOGY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

(2008) Francesca Bartolini et al.   JOURNAL OF CELL BIOLOGY