Altered Lipid Tumor Environment and Its Potential Effects on NKT Cell Function in Tumor Immunity

TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells

(2019) Christophe Paget et al.   PLOS BIOLOGY

Intratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory

(2019) Anja C. Bloom et al.   OncoImmunology

Niche signals and transcription factors involved in tissue-resident macrophage development

(2018) Wouter T'Jonck et al.   CELLULAR IMMUNOLOGY

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer

(2018) Yang-An Wen et al.   Cell Death & Disease

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a

(2018) Shweta Tiwary et al.   Scientific Reports

Lipid Accumulation in Peripheral Blood Dendritic Cells and Anticancer Immunity in Patients with Lung Cancer

(2018) Ryo Arai et al.   Journal of Immunology Research

CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides

(2018) Yusuke Nishioka et al.   Frontiers in Immunology

Unraveling Natural Killer T-Cells Development

(2018) Sabrina Bianca Bennstein   Frontiers in Immunology

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

(2018) Valerio Chiurchiù et al.   Frontiers in Immunology

Tissue-Specific Roles of NKT Cells in Tumor Immunity

(2018) Masaki Terabe et al.   Frontiers in Immunology

Resolvins suppress tumor growth and enhance cancer therapy

(2017) Megan L. Sulciner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type II NKT Cells and Their Emerging Role in Health and Disease

(2017) Madhav V. Dhodapkar et al.   JOURNAL OF IMMUNOLOGY

Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells

(2017) Y Wang et al.   Mucosal Immunology

Implications of dietary ω‑3 and ω‑6 polyunsaturated fatty acids in breast cancer (Review)

(2017) Oana Zanoaga et al.   Experimental and Therapeutic Medicine

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

(2017) Filippo Veglia et al.   Nature Communications

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer

(2016) Ikrame Lazar et al.   CANCER RESEARCH

VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells

(2016) Irina V. Tiper et al.   CLINICAL CANCER RESEARCH

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset

(2016) Suryasarathi Dasgupta et al.   IMMUNOGENETICS

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

PPARγas a Novel Therapeutic Target in Lung Cancer

(2016) Aravind T. Reddy et al.   PPAR Research

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer

(2016) Lauren V. Wood et al.   OncoImmunology

Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy

(2016) Donatella D’Eliseo et al.   Journal of Clinical Medicine

Adipocyte-specific CD1d-deficiency mitigates diet-induced obesity and insulin resistance in mice

(2016) Masashi Satoh et al.   Scientific Reports

NKT cells act through third party bone marrow-derived cells to suppress NK cell activity in the liver and exacerbate hepatic melanoma metastases

(2015) Leila Sadegh et al.   INTERNATIONAL JOURNAL OF CANCER

Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation

(2015) Alysia Birkholz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer

(2015) Fu Gao et al.   Scientific Reports

Lipid–protein interactions as determinants of membrane protein structure and function

(2015) William Dowhan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

(2015) Deliang Guo et al.   CURRENT PHARMACEUTICAL DESIGN

Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation

(2014) S. Nair et al.   BLOOD

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Different subsets of natural killer T cells may vary in their roles in health and disease

(2014) Vipin Kumar et al.   IMMUNOLOGY

NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis

(2014) J. A. Berzofsky et al.   JOURNAL OF IMMUNOLOGY

Lipids in cell biology: how can we understand them better?

(2014) Eleonora Muro et al.   MOLECULAR BIOLOGY OF THE CELL

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Prognostic Role of 14F7 Mab Immunoreactivity against N-Glycolyl GM3 Ganglioside in Colon Cancer

(2014) Tania Lahera et al.   Journal of Oncology

Natural Killer T cell obsession with self-antigens

(2013) Laurent Gapin et al.   CURRENT OPINION IN IMMUNOLOGY

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Role of Fatty-Acid Synthesis in Dendritic Cell Generation and Function

(2013) A. Rehman et al.   JOURNAL OF IMMUNOLOGY

Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death

(2013) Tongfang Tang et al.   PLoS One

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

(2013) H. Zirath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

(2013) R. V. V. Tatituri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

(2013) Nousheen Zaidi et al.   PROGRESS IN LIPID RESEARCH

Current Evidence Linking Polyunsaturated Fatty Acids with Cancer Risk and Progression

(2013) Maria Azrad et al.   Frontiers in Oncology

Molecular Identification of GD3 as a Suppressor of the Innate Immune Response in Ovarian Cancer

(2012) T. J. Webb et al.   CANCER RESEARCH

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C

(2012) Anneliese O. Speak et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells

(2012) Enrico Girardi et al.   IMMUNOLOGICAL REVIEWS

Globosides but Not Isoglobosides Can Impact the Development of Invariant NKT Cells and Their Interaction with Dendritic Cells

(2012) S. Porubsky et al.   JOURNAL OF IMMUNOLOGY

Type II NKT Cells Stimulate Diet-Induced Obesity by Mediating Adipose Tissue Inflammation, Steatohepatitis and Insulin Resistance

(2012) Masashi Satoh et al.   PLoS One

iNKT Cells Suppress the CD8+ T Cell Response to a Murine Burkitt’s-Like B Cell Lymphoma

(2012) Ryan L. Bjordahl et al.   PLoS One

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

(2012) L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals

(2011) Vladimir A. Tyurin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PLZF induces an intravascular surveillance program mediated by long-lived LFA-1–ICAM-1 interactions

(2011) Seddon Y. Thomas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Structures, Biosynthesis, and Functions of Gangliosides-an Overview

(2011) Robert K. Yu et al.   Journal of Oleo Science

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

(2011) N. B. Kuemmerle et al.   MOLECULAR CANCER THERAPEUTICS

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity

(2011) Benjamin S. Mantell et al.   PLoS One

Unique Interplay between Sugar and Lipid in Determining the Antigenic Potency of Bacterial Antigens for NKT Cells

(2011) Enrico Girardi et al.   PLOS BIOLOGY

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice

(2010) Yawei Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a  -linked self-glycolipid

(2010) P. Arrenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Invariant Natural Killer T Cells Regulate Breast Cancer Response to Radiation and CTLA-4 Blockade

(2009) K. A. Pilones et al.   CLINICAL CANCER RESEARCH

Determination of Cellular Lipids Bound to Human CD1d Molecules

(2009) Daryl Cox et al.   PLoS One

Secondary lipid accumulation in lysosomal disease

(2008) Steven U. Walkley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer

(2008) D. H. Chang et al.   BLOOD

Peroxisome Proliferator-Activated Receptor  -Mediated Up-regulation of Syndecan-1 by n-3 Fatty Acids Promotes Apoptosis of Human Breast Cancer Cells

(2008) H. Sun et al.   CANCER RESEARCH

Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand

(2008) Jun-Eui Park et al.   IMMUNOLOGY

Membranes: a meeting point for lipids, proteins and therapies

(2008) Pablo V. Escribá et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ:RXR heterodimers: comparison with other polyunsaturated fatty acids

(2008) Fernando Zapata-Gonzalez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential Effects of a Saturated and a Monounsaturated Fatty Acid on MHC Class I Antigen Presentation

(2008) S. R. Shaikh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY