Chemokines in Physiological and Pathological Bone Remodeling

Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis

(2019) Tobias Schmidt et al.   JOURNAL OF HEPATOLOGY

CXCL2 attenuates osteoblasts differentiation by inhibiting ERK1/2 signaling pathway

(2019) Yang Yang et al.   JOURNAL OF CELL SCIENCE

Chemokine receptor 3 is a negative regulator of trabecular bone mass in female mice

(2019) Subburaman Mohan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Imbalanced Osteogenesis and Adipogenesis in Mice Deficient in the Chemokine Cxcl12/Sdf1 in the Bone Mesenchymal Stem/Progenitor Cells

(2018) Yi-Shiuan Tzeng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Balixafortide plus eribulin in HER2-negative metastatic breast cancer: a phase 1, single-arm, dose-escalation trial

(2018) Sonia Pernas et al.   LANCET ONCOLOGY

Paget's disease of bone

(2018) Tim Cundy   METABOLISM-CLINICAL AND EXPERIMENTAL

Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity

(2018) Matthew C. Walsh et al.   Nature Reviews Rheumatology

Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis

(2018) Lauren A Jordan et al.   RHEUMATOLOGY

CCL4 enhances preosteoclast migration and its receptor CCR5 downregulation by RANKL promotes osteoclastogenesis

(2018) Dabin Lee et al.   Cell Death & Disease

Correlation of Serum CCL3/MIP-1α Levels with Disease Severity in Postmenopausal Osteoporotic Females

(2018) Hui Wan et al.   Balkan Medical Journal

B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation

(2018) Wen Sun et al.   Nature Communications

Chemokines from a Structural Perspective

(2017) Michelle Miller et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Regulation of the Chemokine-Receptor Network

(2017) Martin Stone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study

(2017) Ravi Salgia et al.   INVESTIGATIONAL NEW DRUGS

Involvement of CX3CL1 in the Migration of Osteoclast Precursors Across Osteoblast Layer Stimulated by Interleukin-1ß

(2017) Tsuyoshi Matsuura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis

(2017) Yoshiya Tanaka et al.   Modern Rheumatology

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

The Biology of Bone Metastasis

(2017) Mark Esposito et al.   Cold Spring Harbor Perspectives in Medicine

Osteoporosis treatment: recent developments and ongoing challenges

(2017) Sundeep Khosla et al.   Lancet Diabetes & Endocrinology

CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone

(2017) Jawed Akhtar Siddiqui et al.   Frontiers in Endocrinology

Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice

(2017) Laura J. Brylka et al.   PLoS One

CCL11, a novel mediator of inflammatory bone resorption

(2017) Elin Kindstedt et al.   Scientific Reports

Human antigen R-regulated CCL20 contributes to osteolytic breast cancer bone metastasis

(2017) Sun Kyoung Lee et al.   Scientific Reports

Potential Role of DARC–Chemokine Interaction in the Recruitment of Osteoclast Precursors in Response to Bacterial Lipopolysaccharide Challenge

(2016) Fatemeh Alemi et al.   CALCIFIED TISSUE INTERNATIONAL

Osteoimmunology and Beyond

(2016) Lia Ginaldi et al.   CURRENT MEDICINAL CHEMISTRY

Plerixafor for stem cell mobilization

(2016) Yavuz M. Bilgin et al.   CURRENT OPINION IN HEMATOLOGY

Upregulated expression of CCR3 in osteoarthritis and CCR3 mediated activation of fibroblast-like synoviocytes

(2016) Xin Chang et al.   CYTOKINE

CCL20/CCR6 Signaling Regulates Bone Mass Accrual in Mice

(2016) Michele Doucet et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammatory Osteoclasts Prime TNFα-Producing CD4+T Cells and Express CX3CR1

(2016) Lidia Ibáñez et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblasts

(2016) Özge Uluçkan et al.   Science Translational Medicine

CXCR4+ CD45− Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow

(2016) Yoh Goto et al.   STEM CELLS

Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone

(2016) Bin Huang et al.   Nature Communications

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis

(2016) Nida Meednu et al.   Arthritis & Rheumatology

Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response

(2016) Raffaella Bonecchi et al.   Frontiers in Immunology

Bone development

(2015) Agnes D. Berendsen et al.   BONE

Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer

(2015) Aimalie L. Hardaway et al.   CLINICAL & EXPERIMENTAL METASTASIS

BMP2 Regulation of CXCL12 Cellular, Temporal, and Spatial Expression Is Essential During Fracture Repair

(2015) Timothy J Myers et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5

(2015) Timur A Yorgan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone remodeling in the context of cellular and systemic regulation: the role of osteocytes and the nervous system

(2015) Tadeusz Niedźwiedzki et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Chemokine System in Innate Immunity

(2015) Caroline L. Sokol et al.   Cold Spring Harbor Perspectives in Biology

CXCL8 and CCL20 Enhance Osteoclastogenesis via Modulation of Cytokine Production by Human Primary Osteoblasts

(2015) Janak L. Pathak et al.   PLoS One

The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice

(2015) Naoyuki Kawao et al.   PLoS One

The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

(2015) Kosuke Mizutani et al.   NEOPLASIA

Osteoblast and osteocyte: Games without frontiers

(2014) Mattia Capulli et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans

(2014) Archana Kamalakar et al.   BONE

Vascular expression of the chemokine CX3CL1 promotes osteoclast recruitment and exacerbates bone resorption in an irradiated murine model

(2014) Ki Hoon Han et al.   BONE

Osteoblast inhibition by chemokine cytokine ligand3 in myeloma-induced bone disease

(2014) Rong Fu et al.   Cancer Cell International

Chemokine signaling in development and disease

(2014) J. Wang et al.   DEVELOPMENT

SDF-1 signaling: a promising target in rheumatic diseases

(2014) Amanda Villalvilla et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Bone marrow Th17 TNFα cells induce osteoclast differentiation, and link bone destruction to IBD

(2014) Thomas Ciucci et al.   GUT

SDF-1/CXCR4 Axis in Tie2-Lineage Cells Including Endothelial Progenitor Cells Contributes to Bone Fracture Healing

(2014) Yohei Kawakami et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MCP-1 as a Potential Target to Inhibit the Bone Invasion by Oral Squamous Cell Carcinoma

(2014) Jingjing Quan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

The Macrophage Inflammatory Proteins MIP1α(CCL3) and MIP2α(CXCL2) in Implant-Associated Osteomyelitis: Linking Inflammation to Bone Degradation

(2014) Ulrike Dapunt et al.   MEDIATORS OF INFLAMMATION

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

MCP-1 Expression Is Specifically Regulated During Activation of Skeletal Repair and Remodeling

(2013) A. C. Wu et al.   CALCIFIED TISSUE INTERNATIONAL

CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations

(2013) Mohammad Shahnazari et al.   FASEB JOURNAL

Age-related CXC chemokine receptor-4-deficiency impairs osteogenic differentiation potency of mouse bone marrow mesenchymal stromal stem cells

(2013) Liang G. Guang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5)

(2013) Kristofer Wintges et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone

(2013) Joseph A Tamasi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CXCL5 stimulation of RANK ligand expression in Paget’s disease of bone

(2013) Kumaran Sundaram et al.   LABORATORY INVESTIGATION

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

Osteoclasts: New Insights

(2013) Feng Xu et al.   Bone Research

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

(2012) D. J. Dairaghi et al.   BLOOD

CXCL10 Promotes Osteolytic Bone Metastasis by Enhancing Cancer Outgrowth and Osteoclastogenesis

(2012) J.-H. Lee et al.   CANCER RESEARCH

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts

(2012) A. Hoshino et al.   JOURNAL OF CELL SCIENCE

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Inflammatory bone loss: pathogenesis and therapeutic intervention

(2012) Kurt Redlich et al.   NATURE REVIEWS DRUG DISCOVERY

Novel therapies in benign and malignant bone diseases

(2012) Tilman D. Rachner et al.   PHARMACOLOGY & THERAPEUTICS

Accelerated Growth Plate Mineralization and Foreshortened Proximal Limb Bones in Fetuin-A Knockout Mice

(2012) Jong Seto et al.   PLoS One

Sclerostin: Therapeutic Horizons Based Upon Its Actions

(2012) Aline G. Costa et al.   Current Osteoporosis Reports

CXCL2 mediates lipopolysaccharide-induced osteoclastogenesis in RANKL-primed precursors

(2011) Jeongim Ha et al.   CYTOKINE

CXCR3 in T cell function

(2011) Joanna R. Groom et al.   EXPERIMENTAL CELL RESEARCH

Mechanisms of cancer cell metastasis to the bone: a multistep process

(2011) Lalit R Patel et al.   Future Oncology

Conditional Inactivation of the CXCR4 Receptor in Osteoprecursors Reduces Postnatal Bone Formation Due to Impaired Osteoblast Development

(2011) Wei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of bone formation by the serpentine receptor Frizzled-9

(2011) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Absence of MCP-1 leads to elevated bone mass via impaired actin ring formation

(2011) Ok-Joo Sul et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IL-33 Shifts the Balance from Osteoclast to Alternatively Activated Macrophage Differentiation and Protects from TNF- -Mediated Bone Loss

(2011) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

(2011) S Vallet et al.   LEUKEMIA

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

(2011) Wei Tan et al.   NATURE

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis

(2010) Heidi Kokkonen et al.   ARTHRITIS AND RHEUMATISM

Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration

(2010) J. Moreaux et al.   BLOOD

CXC receptor knockout mice: Characterization of skeletal features and membranous bone healing in the adult mouse☆

(2010) David S. Bischoff et al.   BONE

Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation

(2010) Lei Wei et al.   DEVELOPMENTAL BIOLOGY

Multiple roles for CCR2 during fracture healing

(2010) Z. Xing et al.   Disease Models & Mechanisms

Deficiency of Chemokine Receptor CCR1 Causes Osteopenia Due to Impaired Functions of Osteoclasts and Osteoblasts

(2010) Akiyoshi Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells

(2010) Jochen Schulze et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CXC Chemokine Ligand 2 Induced by Receptor Activator of NF- B Ligand Enhances Osteoclastogenesis

(2010) J. Ha et al.   JOURNAL OF IMMUNOLOGY

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model

(2009) Toshiyuki Kitaori et al.   ARTHRITIS AND RHEUMATISM

CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis

(2009) Jian Zhang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeted Disruption of the CXCL12/CXCR4 Axis Inhibits Osteolysis in a Murine Model of Myeloma-Associated Bone Loss

(2009) Peter Diamond et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption

(2009) K. Koizumi et al.   JOURNAL OF IMMUNOLOGY

Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in osteoporosis

(2009) Nikolaus B Binder et al.   NATURE MEDICINE

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemokines as Mediators of Neovascularization

(2008) Ellen C. Keeley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reciprocal cross-talk between RANKL and interferon-γ–inducible protein 10 is responsible for bone-erosive experimental arthritis

(2008) Han Bok Kwak et al.   ARTHRITIS AND RHEUMATISM

Gene expression profile of the bone microenvironment in human fragility fracture bone

(2008) B. Hopwood et al.   BONE

Infantile Malignant, Autosomal Recessive Osteopetrosis: The Rich and The Poor

(2008) Anna Villa et al.   CALCIFIED TISSUE INTERNATIONAL

CC-Chemokine Ligand 20/Macrophage Inflammatory Protein-3  and CC-Chemokine Receptor 6 Are Overexpressed in Myeloma Microenvironment Related to Osteolytic Bone Lesions

(2008) N. Giuliani et al.   CANCER RESEARCH

Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice

(2008) Han Gerrits et al.   GENESIS

Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells

(2008) Alan P. Molloy et al.   INTERNATIONAL JOURNAL OF CANCER

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

(2008) Monika Pruenster et al.   NATURE IMMUNOLOGY