Journal
NANOMATERIALS
Volume 9, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/nano9091329
Keywords
drug delivery; nanomedicine; cancer therapy; cancer imaging; virus-like particles; protein-based nanoparticles; synthetic biology
Categories
Funding
- international Macquarie University Research Excellence Scholarship (iMQRES)
- Commonwealth Scientific and Industrial Research Organization (CSIRO) scholarship [50068016]
- Cancer Institute's New South Wales Early Career Fellowship [ECF171114]
- Australian Research Council [CE140100003]
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In recent years, it has become apparent that cancer nanomedicine's reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their bio-nano interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic.
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