The Role of Innate Leukocytes during Influenza Virus Infection

PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection

(2019) Su Huang et al.   JOURNAL OF VIROLOGY

Human Blood and Tonsil Plasmacytoid Dendritic Cells Display Similar Gene Expression Profiles but Exhibit Differential Type I IFN Responses to Influenza A Virus Infection

(2019) Sindhu Vangeti et al.   JOURNAL OF IMMUNOLOGY

Eosinophils: Nemeses of Pulmonary Pathogens?

(2019) Kim S. LeMessurier et al.   CURRENT ALLERGY AND ASTHMA REPORTS

The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity

(2018) Maude Liegeois et al.   CELLULAR IMMUNOLOGY

T cells and ILC2s are major effector cells in influenza-induced exacerbation of allergic airway inflammation in mice

(2018) Bobby W. S. Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clinical characteristics and severity of influenza infections by virus type, subtype, and lineage: A systematic literature review

(2018) Saverio Caini et al.   Influenza and Other Respiratory Viruses

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection

(2018) Liuluan Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Host Immune Response to Influenza A Virus Infection

(2018) Xiaoyong Chen et al.   Frontiers in Immunology

Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

(2018) Lindsey E. Carlin et al.   Frontiers in Immunology

Differential Ability of Pandemic and Seasonal H1N1 Influenza A Viruses To Alter the Function of Human Neutrophils

(2018) Natalia Malachowa et al.   mSphere

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity

(2018) Xi-zhi J. Guo et al.   IMMUNITY

Laboratory epidemiology of respiratory viruses in a large childrenʼs hospital

(2018) Sheng Ye et al.   MEDICINE

γδ T Cells Provide Protective Function in Highly Pathogenic Avian H5N1 Influenza A Virus Infection

(2018) Peng Dong et al.   Frontiers in Immunology

Macrophage CD14 impacts immune defenses against influenza virus in allergic hosts

(2018) Maneesha Palipane et al.   MICROBIAL PATHOGENESIS

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Humoral immune responses during asthma and influenza co-morbidity in mice

(2017) Laura A. Doorley et al.   IMMUNOBIOLOGY

Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes

(2017) Andrew C. Y Lee et al.   JOURNAL OF GENERAL VIROLOGY

Influenza virus replication in macrophages: balancing protection and pathogenesis

(2017) Troy D. Cline et al.   JOURNAL OF GENERAL VIROLOGY

Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus

(2017) Amali E. Samarasinghe et al.   JOURNAL OF IMMUNOLOGY

Exosomes from eosinophils autoregulate and promote eosinophil functions

(2017) José Antonio Cañas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Determining the burden of respiratory syncytial virus disease: the known and the unknown

(2017) Ruth A Karron et al.   LANCET

Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection

(2017) K M Robinson et al.   Mucosal Immunology

IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells

(2017) D Califano et al.   Mucosal Immunology

Alveolar Macrophages Prevent Lethal Influenza Pneumonia By Inhibiting Infection Of Type-1 Alveolar Epithelial Cells

(2017) Amber Cardani et al.   PLoS Pathogens

Epidemiology of fatal cases associated with pandemic H1N1 influenza 2009

(2017) L Vaillant et al.   Eurosurveillance

Prevalence of respiratory viruses among adults, by season, age, respiratory tract region and type of medical unit in Paris, France, from 2011 to 2016

(2017) Benoit Visseaux et al.   PLoS One

A joint analysis of influenza-associated hospitalizations and mortality in Hong Kong, 1998–2013

(2017) Peng Wu et al.   Scientific Reports

Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo

(2017) Anthony DiPiazza et al.   Scientific Reports

Antimicrobial peptides alter early immune response to influenza A virus infection in C57BL/6 mice

(2016) Kim S. LeMessurier et al.   ANTIVIRAL RESEARCH

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Dendritic Cells and Monocytes with Distinct Inflammatory Responses Reside in Lung Mucosa of Healthy Humans

(2016) Faezzah Baharom et al.   JOURNAL OF IMMUNOLOGY

Human Alveolar Macrophages May Not Be Susceptible to Direct Infection by a Human Influenza Virus

(2016) David B. Ettensohn et al.   JOURNAL OF INFECTIOUS DISEASES

Arginine-rich histones have strong antiviral activity for influenza A viruses

(2015) Marloes Hoeksema et al.   Innate Immunity

Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle

(2015) Sarah L. Londrigan et al.   JOURNAL OF VIROLOGY

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Neutrophil trails guide influenza-specific CD8+ T cells in the airways

(2015) K. Lim et al.   SCIENCE

Innate lymphoid cells: A new paradigm in immunology

(2015) G. Eberl et al.   SCIENCE

Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils

(2015) Zhang Zhang et al.   Scientific Reports

Cross-species transmission and emergence of novel viruses from birds

(2015) Jasper Fuk-Woo Chan et al.   Current Opinion in Virology

Blood Monocytes and Their Subsets: Established Features and Open Questions

(2015) Loems Ziegler-Heitbrock   Frontiers in Immunology

Human and Mouse Mononuclear Phagocyte Networks: A Tale of Two Species?

(2015) Gary Reynolds et al.   Frontiers in Immunology

Continuing challenges in influenza

(2014) Robert G. Webster et al.   Annals of the New York Academy of Sciences

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

The role of macrophages in influenza A virus infection

(2014) Marlynne Q Nicol et al.   Future Virology

The immune profile associated with acute allergic asthma accelerates clearance of influenza virus

(2014) Amali E Samarasinghe et al.   IMMUNOLOGY AND CELL BIOLOGY

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

(2014) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cells Are Dispensable during Primary Influenza Virus Infection

(2014) A. I. Wolf et al.   JOURNAL OF IMMUNOLOGY

Lymphopenia Associated with Highly Virulent H5N1 Virus Infection Due to Plasmacytoid Dendritic Cell-Mediated Apoptosis of T Cells

(2014) K. Boonnak et al.   JOURNAL OF IMMUNOLOGY

LL-37 modulates human neutrophil responses to influenza A virus

(2014) Shweta Tripathi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Early Responses of Natural Killer Cells in Pigs Experimentally Infected with 2009 Pandemic H1N1 Influenza A Virus

(2014) Hilde Forberg et al.   PLoS One

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection

(2014) Christoph Schneider et al.   PLoS Pathogens

Identification of Myeloid Cell Subsets in Murine Lungs Using Flow Cytometry

(2013) Rinat Zaynagetdinov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Human Vγ9Vδ2-T cells efficiently kill influenza virus-infected lung alveolar epithelial cells

(2013) Hong Li et al.   Cellular & Molecular Immunology

The interaction of influenza H5N1 viral hemagglutinin with sialic acid receptors leads to the activation of human γδ T cells

(2013) Yanlai Lu et al.   Cellular & Molecular Immunology

Human Rhinoviruses

(2013) Samantha E. Jacobs et al.   CLINICAL MICROBIOLOGY REVIEWS

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Visualizing influenza virus infection in living mice

(2013) Weiqi Pan et al.   Nature Communications

Global Mortality Estimates for the 2009 Influenza Pandemic from the GLaMOR Project: A Modeling Study

(2013) Lone Simonsen et al.   PLOS MEDICINE

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Group 2 Innate Lymphoid Cell Production of IL-5 Is Regulated by NKT Cells during Influenza Virus Infection

(2013) Stacey Ann Gorski et al.   PLoS Pathogens

Glutathione Peroxidase-1 Reduces Influenza A Virus–Induced Lung Inflammation

(2012) Selcuk Yatmaz et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lung Dendritic Cells in Respiratory Viral Infection and Asthma: From Protection to Immunopathology

(2012) Bart N. Lambrecht et al.   Annual Review of Immunology

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Plasmacytoid dendritic cell depletion leads to an enhanced mononuclear phagocyte response in lungs of mice with lethal influenza virus infection

(2012) Adam C. Soloff et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Neutrophils infected with highly virulent influenza H3N2 virus exhibit augmented early cell death and rapid induction of type I interferon signaling pathways

(2012) Fransiskus X. Ivan et al.   GENOMICS

Intensive care unit patients with 2009 pandemic influenza A (H1N1pdm09) virus infection - United States, 2009

(2012) Anna M. Bramley et al.   Influenza and Other Respiratory Viruses

Interleukin-22 Is Produced by Invariant Natural Killer T Lymphocytes during Influenza A Virus Infection

(2012) Christophe Paget et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection

(2012) Julie Helft et al.   JOURNAL OF CLINICAL INVESTIGATION

Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages

(2012) Judith Friesenhagen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection

(2012) P Kumar et al.   Mucosal Immunology

Innate Immune Response of Human Alveolar Macrophages during Influenza A Infection

(2012) Jieru Wang et al.   PLoS One

Influenza Virus A Infection of Human Monocyte and Macrophage Subpopulations Reveals Increased Susceptibility Associated with Cell Differentiation

(2012) Marieke A. Hoeve et al.   PLoS One

CCR2 Defines a Distinct Population of NK Cells and Mediates Their Migration during Influenza Virus Infection in Mice

(2012) Mary J. G. van Helden et al.   PLoS One

Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8+ T Cells

(2012) Matthew M. Hufford et al.   PLoS One

Interleukin-33 and the function of innate lymphoid cells

(2012) Ananda S. Mirchandani et al.   TRENDS IN IMMUNOLOGY

Dendritic cells and influenza A virus infection

(2012) Jason Waithman et al.   Virulence

Matrix Metalloprotease 9 Mediates Neutrophil Migration into the Airways in Response to Influenza Virus-Induced Toll-Like Receptor Signaling

(2012) Linda M. Bradley et al.   PLoS Pathogens

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Infection with Influenza Virus Induces IL-33 in Murine Lungs

(2011) Ronan Le Goffic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Disease burden of the most commonly detected respiratory viruses in hospitalized patients calculated using the disability adjusted life year (DALY) model

(2011) E.R. Gaunt et al.   JOURNAL OF CLINICAL VIROLOGY

The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice

(2011) Wenwei Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lung CD103+ Dendritic Cells Efficiently Transport Influenza Virus to the Lymph Node and Load Viral Antigen onto MHC Class I for Presentation to CD8 T Cells

(2011) A. W. S. Ho et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection

(2011) Wai Ling Kok et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Type 1 Responses of Human V 9V 2 T Cells to Influenza A Viruses

(2011) G. Qin et al.   JOURNAL OF VIROLOGY

Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses

(2011) W. C. L. Yu et al.   JOURNAL OF VIROLOGY

Early induction of interleukin-5 and peripheral eosinophilia in acute pneumonia in Japanese children infected by pandemic 2009 influenza A in the Tokyo area

(2011) Masaru Terai et al.   MICROBIOLOGY AND IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice

(2011) Michelle D. Tate et al.   PLoS One

Severe and Persistent Depletion of Circulating Plasmacytoid Dendritic Cells in Patients with 2009 Pandemic H1N1 Infection

(2011) Miriam Lichtner et al.   PLoS One

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Clinical and Virological Factors Associated with Viremia in Pandemic Influenza A/H1N1/2009 Virus Infection

(2011) Herman Tse et al.   PLoS One

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

Immune responses to influenza virus infection

(2011) J.H.C.M. Kreijtz et al.   VIRUS RESEARCH

Unique Type I Interferon Responses Determine the Functional Fate of Migratory Lung Dendritic Cells during Influenza Virus Infection

(2011) Bruno Moltedo et al.   PLoS Pathogens

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human γδ T lymphocytes

(2010) Julie M. Jameson et al.   CELLULAR IMMUNOLOGY

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice

(2010) Julie Helft et al.   IMMUNOLOGICAL REVIEWS

Original Article: Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice

(2010) Carson E. Moseley et al.   Influenza and Other Respiratory Viruses

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cells Enhance Mortality during Lethal Influenza Infections by Eliminating Virus-Specific CD8 T Cells

(2010) R. A. Langlois et al.   JOURNAL OF IMMUNOLOGY

Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Differential Activation of NK Cells by Influenza A Pseudotype H5N1 and 1918 and 2009 Pandemic H1N1 Viruses

(2010) N. Du et al.   JOURNAL OF VIROLOGY

Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice

(2010) M. D. Tate et al.   JOURNAL OF VIROLOGY

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

(2010) B. Manicassamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors Associated With Death or Hospitalization Due to Pandemic 2009 Influenza A(H1N1) Infection in California

(2009) Janice K. Louie   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

(2009) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Phosphoantigen‐Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte‐Derived Macrophages Infected with Human and Avian Influenza Viruses

(2009) Gang Qin et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza Virus Directly Infects Human Natural Killer Cells and Induces Cell Apoptosis

(2009) H. Mao et al.   JOURNAL OF VIROLOGY

Dendritic cell subsets in primary and secondary T cell responses at body surfaces

(2009) William R Heath et al.   NATURE IMMUNOLOGY

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses

(2009) Taeg S. Kim et al.   PLoS One

Plasmacytoid Dendritic Cells Capture and Cross-Present Viral Antigens from Influenza-Virus Exposed Cells

(2009) Gabrielle Lui et al.   PLoS One

(Highly pathogenic) avian influenza as a zoonotic agent

(2009) Donata Kalthoff et al.   VETERINARY MICROBIOLOGY

The Pathology of Influenza Virus Infections

(2008) Jeffery K. Taubenberger et al.   Annual Review of Pathology-Mechanisms of Disease

Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza

(2008) Yingying Zhao et al.   CLINICAL INFECTIOUS DISEASES

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

(2008) Carmela De Santo et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance of influenza virus from the lung depends on migratory langerin+CD11b−but not plasmacytoid dendritic cells

(2008) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Differential Recruitment of Dendritic Cells and Monocytes to Respiratory Mucosal Sites in Children with Influenza Virus or Respiratory Syncytial Virus Infection

(2008) Michelle A. Gill et al.   JOURNAL OF INFECTIOUS DISEASES

Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially

(2008) L. A. Spencer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs

(2008) H. M. Kim et al.   JOURNAL OF VIROLOGY

Neutrophils Play an Essential Role in Cooperation with Antibody in both Protection against and Recovery from Pulmonary Infection with Influenza Virus in Mice

(2008) H. Fujisawa   JOURNAL OF VIROLOGY

A critical function for CD200 in lung immune homeostasis and the severity of influenza infection

(2008) Robert J Snelgrove et al.   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Analysis of cytokine secretion from human plasmacytoid dendritic cells infected with H5N1 or low-pathogenicity influenza viruses

(2008) Matthew R. Sandbulte et al.   VIROLOGY

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens