Host Invasion by Pathogenic Amoebae: Epithelial Disruption by Parasite Proteins

Rhinoviruses and Their Receptors

(2019) Sarmila Basnet et al.   CHEST

Transcriptomic analysis reveals novel downstream regulatory motifs and highly transcribed virulence factor genes of Entamoeba histolytica

(2019) Sarah Naiyer et al.   BMC GENOMICS

EhRho1 regulates phagocytosis by modulating actin dynamics through EhFormin1 and EhProfilin1 in Entamoeba histolytica

(2018) Ravi Bharadwaj et al.   CELLULAR MICROBIOLOGY

Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri

(2018) Ingrid Zyserman et al.   EXPERIMENTAL PARASITOLOGY

An In Vitro Model of the Blood-Brain Barrier: Naegleria fowleri Affects the Tight Junction Proteins and Activates the Microvascular Endothelial Cells

(2018) Daniel Coronado-Velázquez et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Intestinal barriers protect against disease

(2018) Sandra Citi   SCIENCE

The Conserved ESCRT-III Machinery Participates in the Phagocytosis of Entamoeba histolytica

(2018) Yunuen Avalos-Padilla et al.   Frontiers in Cellular and Infection Microbiology

Calcium-binding protein EhCaBP3 is recruited to the phagocytic complex of Entamoeba histolytica by interacting with Arp2/3 complex subunit 2

(2018) Mrigya Babuta et al.   CELLULAR MICROBIOLOGY

Stress-induced nuclear depletion ofEntamoeba histolytica3’-5’exoribonuclease EhRrp6 and its role in growth and erythrophagocytosis

(2018) Shashi Shekhar Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial Cells Expressing EhADH, An Entamoeba histolytica Adhesin, Exhibit Increased Tight Junction Proteins

(2018) Abigail Betanzos et al.   Frontiers in Cellular and Infection Microbiology

Molecular and Biochemical Properties of a Cysteine Protease of Acanthamoeba castellanii

(2018) Yeonchul Hong et al.   KOREAN JOURNAL OF PARASITOLOGY

Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development

(2018) Micaella Kantor et al.   Canadian Journal of Gastroenterology and Hepatology

Acanthamoeba culbertsoni isolated from a clinical case with intraocular dissemination: Structure and in vitro analysis of the interaction with hamster cornea and MDCK epithelial cell monolayers

(2017) Arturo González-Robles et al.   EXPERIMENTAL PARASITOLOGY

Acanthamoeba (T4) trophozoites cross the MDCK epithelium without cell damage but increase paracellular permeability and transepithelial resistance by modifying tight junction composition

(2017) Catalina Flores-Maldonado et al.   EXPERIMENTAL PARASITOLOGY

Acanthamoeba-mediated cytopathic effect correlates with MBP and AhLBP mRNA expression

(2017) Sook-Luan Ng et al.   Parasites & Vectors

Strategies used by helicobacter pylori to establish persistent infection

(2017) Amin Talebi Bezmin Abadi   WORLD JOURNAL OF GASTROENTEROLOGY

AGC family kinase 1 participates in trogocytosis but not in phagocytosis in Entamoeba histolytica

(2017) Somlata et al.   Nature Communications

Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium

(2017) Patricia Cuellar et al.   Frontiers in Cellular and Infection Microbiology

Biology and pathogenesis of Naegleria fowleri

(2016) Ruqaiyyah Siddiqui et al.   ACTA TROPICA

Endoplasmic reticulum-resident Rab8A GTPase is involved in phagocytosis in the protozoan parasiteEntamoeba histolytica

(2016) Yuki Hanadate et al.   CELLULAR MICROBIOLOGY

Biophysical studies on calcium and carbohydrate binding to carbohydrate recognition domain of Gal/GalNAc lectin fromEntamoeba histolytica: insights into host cell adhesion

(2016) Rupali Yadav et al.   JOURNAL OF BIOCHEMISTRY

Heterodimerization of the Entamoeba histolytica EhCPADH virulence complex through molecular dynamics and protein–protein docking

(2016) Sarita Montaño et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Entamoeba thiol-based redox metabolism: A potential target for drug development

(2016) Ghulam Jeelani et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

EhNPC1 and EhNPC2 Proteins Participate in Trafficking of Exogenous Cholesterol in Entamoeba histolytica Trophozoites: Relevance for Phagocytosis

(2016) Jeni Bolaños et al.   PLoS Pathogens

Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin

(2016) Steve Cornick et al.   PLoS Pathogens

Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses

(2016) Bruno M. Di Genova et al.   Frontiers in Microbiology

Tackling infection owing to brain-eating amoeba

(2015) Abdul Mannan Baig et al.   ACTA TROPICA

Naegleria fowleri: Pathogenesis, Diagnosis, and Treatment Options

(2015) Eddie Grace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Beyond RGD: virus interactions with integrins

(2015) Hosni A. M. Hussein et al.   ARCHIVES OF VIROLOGY

Acanthamoeba castellaniiProteases are Capable of Degrading Iron-Binding Proteins as a Possible Mechanism of Pathogenicity

(2015) Gerardo Ramírez-Rico et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Role of the Gut Microbiota of Children in Diarrhea Due to the Protozoan ParasiteEntamoeba histolytica

(2015) Carol A. Gilchrist et al.   JOURNAL OF INFECTIOUS DISEASES

Entamoeba histolytica: Adhesins and Lectins in the Trophozoite Surface

(2015) Magdalena Aguirre García et al.   MOLECULES

The knockdown of each component of the cysteine proteinase-adhesin complex of Entamoeba histolytica (EhCPADH) affects the expression of the other complex element as well as the in vitro and in vivo virulence

(2015) RAMÓN OCÁDIZ-RUIZ et al.   PARASITOLOGY

Conceptual barriers to understanding physical barriers

(2015) Amulya Lingaraju et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Variation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence

(2015) Elise R. Morton et al.   PLoS Genetics

EhVps32 Is a Vacuole-Associated Protein Involved in Pinocytosis and Phagocytosis of Entamoeaba histolytica

(2015) Yunuen Avalos-Padilla et al.   PLoS Pathogens

The Entamoeba histolytica, Arp2/3 Complex Is Recruited to Phagocytic Cups through an Atypical Kinase EhAK1

(2015) Mrigya Babuta et al.   PLoS Pathogens

The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

(2015) Leanne Mortimer et al.   PLoS Pathogens

The ways of a killer: how doesEntamoeba histolyticaelicit host cell death?

(2015) Katherine S. Ralston et al.   Essays in Biochemistry

Molecular aspects of tight junction barrier function

(2014) Guo Hua Liang et al.   CURRENT OPINION IN PHARMACOLOGY

Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion

(2014) Katherine S. Ralston et al.   NATURE

Biochemical and cellular mechanisms regulating Acanthamoeba castellanii adherence to host cells

(2014) K. J. SOTO-ARREDONDO et al.   PARASITOLOGY

Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory–secretory proteins and their biochemical properties

(2014) Jinyoung Lee et al.   PARASITOLOGY RESEARCH

After 2015: infectious diseases in a new era of health and development

(2014) C. Dye   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pathogenic Strains of Acanthamoeba Are Recognized by TLR4 and Initiated Inflammatory Responses in the Cornea

(2014) Hassan Alizadeh et al.   PLoS One

The parasite Entamoeba histolytica exploits the activities of human matrix metalloproteinases to invade colonic tissue

(2014) Roman Thibeaux et al.   Nature Communications

Entamoeba histolytica Exacerbates Epithelial Tight Junction Permeability and Proinflammatory Responses in Muc2−/− Mice

(2013) Vanessa Kissoon-Singh et al.   AMERICAN JOURNAL OF PATHOLOGY

Gal-lectin-dependent contact activates the inflammasome by invasive Entamoeba histolytica

(2013) L Mortimer et al.   Mucosal Immunology

Effect of the silencing of the Ehcp112 gene on the in vitro virulence of Entamoeba histolytica

(2013) Ramón Ocádiz-Ruiz et al.   Parasites & Vectors

Naegleria fowleri glycoconjugates with residues of α-d-mannose are involved in adherence of trophozoites to mouse nasal mucosa

(2013) Maricela Carrasco-Yepez et al.   PARASITOLOGY RESEARCH

The small GTPase EhRabB of Entamoeba histolytica is differentially expressed during phagocytosis

(2013) Mario Hernandes-Alejandro et al.   PARASITOLOGY RESEARCH

The EhCPADH112 Complex of Entamoeba histolytica Interacts with Tight Junction Proteins Occludin and Claudin-1 to Produce Epithelial Damage

(2013) Abigail Betanzos et al.   PLoS One

Entamoeba histolytica Contains an Occludin-Like Protein That Can Alter Colonic Epithelial Barrier Function

(2013) Michael Goplen et al.   PLoS One

The α-helical regions of KERP1 are important in Entamoeba histolytica adherence to human cells

(2013) Doranda Perdomo et al.   Scientific Reports

Identification of the Virulence Landscape Essential for Entamoeba histolytica Invasion of the Human Colon

(2013) Roman Thibeaux et al.   PLoS Pathogens

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Real-time analysis of gut flora in Entamoeba histolytica infected patients of Northern India

(2012) Anil Kumar Verma et al.   BMC MICROBIOLOGY

Control of Entamoeba histolytica Adherence Involves Metallosurface Protease 1, an M8 Family Surface Metalloprotease with Homology to Leishmanolysin

(2012) Jose E. Teixeira et al.   INFECTION AND IMMUNITY

EhADH112 Is a Bro1 Domain-Containing Protein Involved in theEntamoeba histolyticaMultivesicular Bodies Pathway

(2012) Cecilia Bañuelos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Pathogenic Naegleria fowleri and non-pathogenic Naegleria lovaniensis exhibit differential adhesion to, and invasion of, extracellular matrix proteins

(2012) M. Jamerson et al.   MICROBIOLOGY-SGM

Disruption of MDCK cell tight junctions by the free-living amoeba Naegleria fowleri

(2012) M. Shibayama et al.   MICROBIOLOGY-SGM

Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba

(2012) Matthias Michalek et al.   Nature Chemical Biology

Pathogenesis of Acanthamoeba Keratitis

(2012) Noorjahan Panjwani   Ocular Surface

IL-1β and IL-6 activate inflammatory responses of astrocytes against Naegleria fowleri infection via the modulation of MAPKs and AP-1

(2012) J.-H. Kim et al.   PARASITE IMMUNOLOGY

Biology and pathogenesis of Acanthamoeba

(2012) Ruqaiyyah Siddiqui et al.   Parasites & Vectors

A functional study of nucleocytoplasmic transport signals of the EhNCABP166 protein from Entamoeba histolytica

(2012) R. URIBE et al.   PARASITOLOGY

Functional expression and characterization of an iron-containing superoxide dismutase of Acanthamoeba castellanii

(2012) Jung-Yeon Kim et al.   PARASITOLOGY RESEARCH

Prostaglandin E2 Produced by Entamoeba histolytica Signals via EP4 Receptor and Alters Claudin-4 to Increase Ion Permeability of Tight Junctions

(2011) Manigandan Lejeune et al.   AMERICAN JOURNAL OF PATHOLOGY

Acanthamoeba is an evolutionary ancestor of macrophages: A myth or reality?

(2011) Ruqaiyyah Siddiqui et al.   EXPERIMENTAL PARASITOLOGY

Mechanisms of adherence, cytotoxicity and phagocytosis modulate the pathogenesis ofEntamoeba histolytica

(2011) Nathaniel CV Christy et al.   Future Microbiology

Entamoeba histolytica Induces Intestinal Cathelicidins but Is Resistant to Cathelicidin-Mediated Killing

(2011) Eduardo R. Cobo et al.   INFECTION AND IMMUNITY

Anatomy and physiology of the cornea

(2011) Derek W. DelMonte et al.   JOURNAL OF CATARACT AND REFRACTIVE SURGERY

Serine-like proteolytic enzymes correlated with differential pathogenicity in patients with acute Acanthamoeba keratitis

(2010) F.R. de Souza Carvalho et al.   CLINICAL MICROBIOLOGY AND INFECTION

Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment*

(2010) Govinda S Visvesvara   CURRENT OPINION IN INFECTIOUS DISEASES

Downregulation of an Entamoeba histolytica Rhomboid Protease Reveals Roles in Regulating Parasite Adhesion and Phagocytosis

(2010) Leigh A. Baxt et al.   EUKARYOTIC CELL

Major Role for Cysteine Proteases during the Early Phase of Acanthamoeba castellanii Encystment

(2010) David Leitsch et al.   EUKARYOTIC CELL

Conservation and function of Rab small GTPases in Entamoeba: Annotation of E. invadens Rab and its use for the understanding of Entamoeba biology

(2010) Kumiko Nakada-Tsukui et al.   EXPERIMENTAL PARASITOLOGY

Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde-alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica

(2010) Erika Pineda et al.   FEBS Journal

Binding to complement factors and activation of the alternative pathway by Acanthamoeba

(2010) Wilawan Pumidonming et al.   IMMUNOBIOLOGY

Members of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis

(2010) Sarah N. Buss et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A NovelEntamoeba histolyticaCysteine Proteinase, EhCP4, Is Key for Invasive Amebiasis and a Therapeutic Target

(2010) Chen He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of the Endosomal Sorting Complex Required for Transport inEntamoeba histolyticaand Characterization of the EhVps4 Protein

(2010) Israel López-Reyes et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thai Acanthamoeba isolate (T4) induced apoptotic death in neuroblastoma cells via the Bax-mediated pathway

(2010) Araya Dharmkrong-at Chusattayanond et al.   PARASITOLOGY INTERNATIONAL

Differences between Naegleria fowleri and Naegleria gruberi in expression of mannose and fucose glycoconjugates

(2010) Isaac Cervantes-Sandoval et al.   PARASITOLOGY RESEARCH

The Nf-actin gene is an important factor for food-cup formation and cytotoxicity of pathogenic Naegleria fowleri

(2010) Hae-Jin Sohn et al.   PARASITOLOGY RESEARCH

Phosphatidylinositol-phosphates mediate cytoskeletal reorganization during phagocytosis via a unique modular protein consisting of RhoGEF/DH and FYVE domains in the parasitic protozoonEntamoeba histolytica

(2009) Kumiko Nakada-Tsukui et al.   CELLULAR MICROBIOLOGY

Twenty Years of Acanthamoeba Keratitis

(2009) F R S Carvalho et al.   CORNEA

Overexpression of a Mutant Form of EhRabA, a Unique Rab GTPase ofEntamoeba histolytica, Alters Endoplasmic Reticulum Morphology and Localization of the Gal/GalNAc Adherence Lectin

(2009) B. H. Welter et al.   EUKARYOTIC CELL

Acanthamoeba affects the integrity of human brain microvascular endothelial cells and degrades the tight junction proteins

(2009) Naveed Ahmed Khan et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

AcanthamoebaInteraction with Extracellular Matrix Glycoproteins: Biological and Biochemical Characterization and Role in Cytotoxicity and Invasiveness

(2009) BRUNO DA ROCHA-AZEVEDO et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Major cysteine peptidases ofEntamoeba histolyticaare required for aggregation and digestion of erythrocytes but are dispensable for phagocytosis and cytopathogenicity

(2009) Henriette Irmer et al.   MOLECULAR MICROBIOLOGY

A pcDNA-Ehcpadh vaccine against Entamoeba histolytica elicits a protective Th1-like response in hamster liver

(2009) Máximo B. Martínez et al.   VACCINE

Tight junctions as targets of infectious agents

(2008) Julian A. Guttman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Modulation of corneal and stromal matrix metalloproteinase by the mannose-induced Acanthamoeba cytolytic protein

(2008) Hassan Alizadeh et al.   EXPERIMENTAL EYE RESEARCH

Entamoeba histolytica: Lipid rafts are involved in adhesion of trophozoites to host extracellular matrix components

(2008) K. Mittal et al.   EXPERIMENTAL PARASITOLOGY

An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion

(2008) L. A. Baxt et al.   GENES & DEVELOPMENT

Mucins in the host defence against Naegleria fowleri and mucinolytic activity as a possible means of evasion

(2008) I. Cervantes-Sandoval et al.   MICROBIOLOGY-SGM

Characterization of brain inflammation during primary amoebic meningoencephalitis

(2008) Isaac Cervantes-Sandoval et al.   PARASITOLOGY INTERNATIONAL

Purification, refolding and autoactivation of the recombinant cysteine proteinase EhCP112 from Entamoeba histolytica

(2008) Laura I. Quintas-Granados et al.   PROTEIN EXPRESSION AND PURIFICATION

Desmosome structure, composition and function

(2007) David Garrod et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES