Cigarette Smoke Reduces Fatty Acid Catabolism, Leading to Apoptosis in Lung Endothelial Cells: Implication for Pathogenesis of COPD

Cigarette Smoke Is an Endothelial Cell Toxin

(2018) Norbert F. Voelkel   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure

(2018) Kenji Mizumura et al.   FASEB JOURNAL

Nrf2 attenuates inflammatory response in COPD/emphysema: Crosstalk with Wnt3a/β-catenin and AMPK pathways

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Imbalance between endothelial damage and repair capacity in chronic obstructive pulmonary disease

(2018) Jéssica García-Lucio et al.   PLoS One

Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury

(2018) Huachun Cui et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fatty Acid Oxidation Protects Against Hyperoxia-Induced Endothelial Cell Apoptosis and Lung Injury in Neonatal Mice

(2018) Hongwei Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

COPD Guidelines: A Review of the 2018 GOLD Report

(2018) Shireen Mirza et al.   MAYO CLINIC PROCEEDINGS

Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD

(2018) Charmion I. Cruickshank-Quinn et al.   Scientific Reports

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Mitochondrial E3 Ubiquitin Protein Ligase 1 Mediates Cigarette Smoke–Induced Endothelial Cell Death and Dysfunction

(2016) Sun-Yong Kim et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype

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Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases

(2016) Li Yue et al.   BRITISH JOURNAL OF PHARMACOLOGY

Environmental Tobacco Smoke Alters Metabolic Systems in Adult Rats

(2016) Dinesh K. Barupal et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cigarette smoke extract induces aberrant cytochrome-c oxidase subunit II methylation and apoptosis in human umbilical vascular endothelial cells

(2015) Min Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema

(2015) T. M. Conlon et al.   CLINICAL SCIENCE

Early chronic obstructive pulmonary disease: definition, assessment, and prevention

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Untargeted Lipidomic Analysis in Chronic Obstructive Pulmonary Disease. Uncovering Sphingolipids

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Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells

(2014) Amit R. Agarwal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Rapid Analysis of Glycolytic and Oxidative Substrate Flux of Cancer Cells in a Microplate

(2014) Lisa S. Pike Winer et al.   PLoS One

Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism

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Metabonomic Profiling of Serum and Urine by 1H NMR-Based Spectroscopy Discriminates Patients with Chronic Obstructive Pulmonary Disease and Healthy Individuals

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Beraprost sodium attenuates cigarette smoke extract-induced apoptosis in vascular endothelial cells

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Pilot analysis of the plasma metabolite profiles associated with emphysematous Chronic Obstructive Pulmonary Disease phenotype

(2011) Mikell Paige et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucose and pyruvate metabolism in severe chronic obstructive pulmonary disease

(2011) Christina C. Kao et al.   JOURNAL OF APPLIED PHYSIOLOGY

Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research

(2011) Simona M. Ceccarelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Targeted Induction of Lung Endothelial Cell Apoptosis Causes Emphysema-like Changes in the Mouse

(2008) Ricardo J. Giordano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maternal Dietary L-Carnitine Supplementation Influences Fetal Carnitine Status and Stimulates Carnitine Palmitoyltransferase and Pyruvate Dehydrogenase Complex Activities in Swine

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