Article
Biochemistry & Molecular Biology
Shohei Kaneko, Katsunori Yanai, Hiroki Ishii, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita
Summary: The role of exogenous miRNAs in renal fibrosis was investigated using a mouse model. miR-122-5p was found to be downregulated in the kidneys of mice with renal fibrosis. Overexpression of miR-122-5p promoted fibrosis, while inhibition of miR-122-5p suppressed fibrosis. miR-122-5p regulated the expression of fibrosis-related mRNAs, including pro-fibrotic TGFBR2 and anti-fibrotic FOXO3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Guanghui Wang, Xiyuan Wei, Shan Gao, Wenheng Chen, Yang Geng, Jia Liu, Hongya Guan
Summary: Circ_LRP6 plays a role in the occurrence and development of osteosarcoma by affecting the proliferation, migration, and invasion of osteosarcoma cells. It interacts with miR-122-5p and miR-204-5p and modulates their target gene HMGB1. The downregulation of miR-122-5p and miR-204-5p and the overexpression of HMGB1 partially restore and weaken the inhibitory effect of circ_LRP6 on osteosarcoma progression.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Fang Qiu, Dafen Ou, Hanxing Tan, Van Gao, Dan Zi
Summary: This study reveals that circular RNA circCDK17 plays a crucial role in the pathogenesis of cervical cancer by competing with miR-122-5p to regulate the expression of ASF1B. Inhibition of circCDK17 expression can suppress the proliferation, migration, and invasion of cervical cancer cells, providing a novel targeted therapy for cervical cancer.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Cell Biology
Chi Pan, Guangzhi Sun, Min Sha, Peng Wang, Yawen Gu, Qingtao Ni
Summary: The study demonstrated that miR-93-5p can reduce the proliferation and migratory capacity of breast cancer cells, increase the ratio of apoptotic cells, and enhance the radiosensitivity of BC cells through increased apoptosis. This indicates that miR-93-5p could be a potential therapeutic target for breast cancer treatment.
Article
Biochemistry & Molecular Biology
Chuang Li, Fang Qin, Wei Wang, Yifan Ni, Mingyu Gao, Mingxiong Guo, Guihong Sun
Summary: The study revealed that miR-122-5p is selectively sorted and secreted into lung cancer EVs through binding to RNA-binding protein hnRNPA2B1, promoting the migration of liver cells. This may contribute to establishing a pre-metastatic micro-environment and hepatic metastasis of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rafal Badacz, Pawel Kleczynski, Jacek Legutko, Krzysztof Zmudka, Jacek Gacon, Tadeusz Przewlocki, Anna Kablak-Ziembicka
Summary: The study investigated circulating microRNAs as potential predictors of subsequent ischemic events in patients with symptomatic coronary or carotid artery involvement. Specific microRNAs were found to be associated with different risks of cardiovascular events, providing new insights for risk assessment in these patients.
Article
Biochemistry & Molecular Biology
Cristina Morsiani, Salvatore Collura, Federica Sevini, Erika Ciurca, Valentina Rosa Bertuzzo, Claudio Franceschi, Gian Luca Grazi, Matteo Cescon, Miriam Capri
Summary: The study aimed to evaluate the changes in circulating microRNA (c-miR) in the blood of liver transplant recipients before and after transplantation, and to correlate their levels with gold standard biomarkers and outcomes such as rejection or complications. The results showed that c-miR changes were associated with follow-up time, and miR-122-5p, miR-92a-3p, and miR-18a-5p exhibited the same trend after transplantation, with an increase in their levels in patients with complications. Compared to changes in standard haemato-biochemical parameters, the importance of c-miRs as potential noninvasive biomarkers for monitoring patient outcomes was confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ailing Gu, Xudong Bao
Summary: MiR-99a-5p is lowly expressed in human cervical squamous cell carcinoma (CSCC) and negatively associated with overall survival. Overexpression of miR-99a-5p can inhibit cell activity, migration, invasion, and promote apoptosis in CSCC cells. MiR-99a-5p targets CDC25A/IL-6 to hinder the epithelial-mesenchymal transition (EMT) process, playing an anti-tumor role in CSCC.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Cell Biology
Yu-kun Zheng, Zhong-shi Zhou, Guang-zhong Wang, Ji-yuan Tu, Huan-bo Cheng, Shang-zhi Ma, Chang Ke, Yan Wang, Qi-pan Jian, Yu-hang Shu, Xiao-wei Wu
Summary: This study found that inhibiting miR-122-5p can activate p53 and hinder the progression of the MVA pathway in non-small cell lung cancer (NSCLC). This leads to a decrease in cell proliferation and migration, and an increase in apoptosis. miR-122-5p interacts with p53 and is negatively correlated with its expression. Thus, miR-122-5p regulates NSCLC by targeting p53, offering potential molecular targets for targeted drug development.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Mengjiao Zhang, Yifeng Wang, Longchen Yu, Yanli Zhang, Yanlei Wang, Ziqi Shang, Yiwei Xin, Xinyang Li, Nannan Ning, Yi Zhang, Xin Zhang
Summary: A study found that Fn infection significantly increased the levels of exosomal miR-122-5p in the serum of CRC patients, and the downregulation of miR-122-5p enhanced the metastatic abilities of CRC cells. Fn activated the TGF-beta 1/Smads signaling pathway through the regulation of the miR-122-5p/FUT8 axis to promote EMT.
Article
Multidisciplinary Sciences
Xiaoping Li, Yanli Ren, Donghong Liu, Xi Yu, Keda Chen
Summary: The miR-100-5p/CDC25A axis plays an important regulatory role in breast carcinoma, and overexpression of miR-100-5p or suppression of CDC25A may contribute to the diagnosis and treatment of breast carcinoma.
Article
Oncology
Wenyan Liao, Jun He, Cyrollah Disoma, Yi Hu, Junhua Li, Guodong Chen, Ying Sheng, Xinyu Cai, Chuanfu Li, Kai Cheng, Chunfen Yang, Yongxi Qin, Dong Han, Wu Wen, Chengming Ding, Mujun Li
Summary: This study demonstrated that hsa_circ_0107593 has low expression in cervical cancer tissues and cell lines, negatively correlated with tumor characteristics, and inhibits cell proliferation, migration, and invasion. It may serve as a diagnostic biomarker due to its tumor-suppressing activity by sponging hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p in cervical cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Liping Zou, Qiwen Feng, Wei Xia, Changhong Zhu
Summary: This study aimed to identify common targets of miR-223-3p, miR-122-5p, and miR-93-5p in PCOS and assess their transcript levels in PCOS rat ovaries. Transcriptome profiles of granulosa cells from PCOS patients were analyzed to identify DEGs, followed by miRNA target prediction and functional analysis. The study identified several potential genes, including JMJD1C, PLCG2, SMAD3, FOSL2, TGFB1, TRIB1, GAS7, TRIM25, NFYA, and CALCRL, which may play a role in the development of PCOS. These findings contribute to the identification of potential biomarkers for the prevention and treatment of PCOS in the future.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Dong Chen, Fu-Ju Chou, Yuhchyau Chen, Chi-Ping Huang, Hao Tian, Yaqin Wang, Yuanjie Niu, Bosen You, Shuyuan Yeh, Nianzeng Xing, Chawnshang Chang
Summary: This study found that radiation therapy (RT) can induce the expression of androgen receptor splice variant 7 (ARv7), leading to decreased sensitivity to radiation therapy, and this effect may be mediated by altering the circNHS/miR-512-5p/XRCC5 signaling pathway. Combining RT with the small molecule Quercetin was found to be more effective in suppressing the progression of prostate cancer (PCa).
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Chunxiang Li, Hengchang Liu, Ran Wei, Zheng Liu, Haipeng Chen, Xu Guan, Zhixun Zhao, Xishan Wang, Zheng Jiang
Summary: This study revealed that EGOT was up-regulated in rectal cancer tissues and cells, and its knockdown inhibited proliferation, colony formation, and induced apoptosis of rectal cancer cells. Additionally, down-regulation of EGOT improved the radiosensitivity of rectal cancer cells by regulating the miR-211-5p/ErbB4 axis. EGOT may serve as a potential therapeutic target for rectal cancer.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Tingting Xu, Xinyi Zhang, Shumao Zhang, Chunfeng Liu, Wenhui Fu, Chengrun Zeng, Yue Chen
Review
Medicine, General & Internal
Sihua Che, Meiling Wang, Le Liu, Shumao Zhang, Guijun Shi
Summary: This study aims to evaluate the effectiveness and safety of Guhong injection for treating coronary heart disease, providing a strong evidence-based medical reference for clinical use.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Junhao Wu, Shumao Zhang, Zijuan Rao, Yingwei Wang, Chunyin Zhang
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Deng, Lin Liu, HaoYuan Ding, ShuMao Zhang, Wei Wang, Wei Zhang, Yi Li
Summary: This study investigated the role of PET/CT in anemia by analyzing the correlation between hemoglobin levels and the uptake of F-18-FDG in the spleen, liver, and bone marrow in patients who underwent PET/CT examinations. The results showed a negative correlation between hemoglobin levels and splenic and hepatic uptake, and a positive correlation with CTV of the LV cavity. These findings have potential clinical significance for the imaging diagnosis of anemia.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lianjun Lan, Shumao Zhang, Tingting Xu, Huipan Liu, Wei Wang, Yue Feng, Li Wang, Yue Chen, Lin Qiu
Summary: Ga-68-FAPI PET/CT showed higher sensitivity than F-18-FDG PET/CT in detecting primary tumors, nodal metastases, and distant metastases in biliary tract cancer. Ga-68-FAPI PET/CT demonstrated higher sensitivity in inflammatory processes secondary to tumor-related obstruction. The study results suggest that Gallium 68-labeled fibroblast-activation protein inhibitor PET/CT may provide more accurate staging information in biliary tract cancer and improve treatment decision making.
Article
Medicine, General & Internal
Lin Liu, Hanxiang Liu, Shijie Xu, Shumao Zhang, Yi Tao, Greta S. P. Mok, Yue Chen
Summary: This study investigated the effects of TVREM reconstruction on Ga-68-DOTA-TATE PET/CT images compared to OSEM. The results showed that TVREM could improve image quality, reduce noise, and increase the SNR, SUVmax, and TBR of lesions. It also has the potential to maintain image quality with shorter acquisition time.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Shumao Zhang, Wei Wang, Tingting Xu, Haoyuan Ding, Yi Li, Huipan Liu, Yinxue Huang, Lin Liu, Tao Du, Yan Zhao, Yue Chen, Lin Qiu
Summary: This study compared the diagnostic efficacy of [Ga-68]Ga-FAPI-04 PET/CT and [F-18]-FDG PET/CT for gastric cancer, showing that [Ga-68]Ga-FAPI-04 PET/CT had higher sensitivity for detecting primary tumors, lymph nodes, and distant metastases. It also provided more accurate information for tumor staging and restaging in gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Junjie Weng, Yang Yu, Jianfa Zhang, Dongying Wang, Zhechun Lu, Zhencheng Wang, Jianqiao Liang, Shumao Zhang, Xiangcheng Li, Yang Lu, Zhou Meng, Junbo Yang, Zhenrong Zhang
Summary: In this paper, a biomimetic optical skin (BOS) based on optical microfiber coupler neuron (OMCN) is proposed, which realizes multimodal tactile perception for the first time. BOS can sensitively detect temperature, contact force, vibration, and recognize the hardness and roughness of objects through human-like tactile sensing. Furthermore, the excellent repeatability and stability of BOS are investigated, laying the foundation for practical applications.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Optics
Jianqiao Liang, Yang Yu, Qiang Bian, Wenjie Xu, Zhencheng Wang, Shumao Zhang, Junjie Weng, Jiajian Zhu, Yong Chen, Xiaoyang Hu, Junbo Yang, Zhenrong Zhang
Summary: Metal coatings can protect optical fiber sensors and extend their lifespan in harsh environments. A nickel-coated fiber Bragg grating combined with an air bubble cavity Fabry-Perot interferometer fiber optic sensor was developed for simultaneous high-temperature and strain sensing. The sensor demonstrated successful testing at 545 degrees C for 0-1000 microstrain, and the characteristic matrix was used to separate temperature and strain. With its ability to attach to high-temperature metal surfaces, the metal-coated optical fiber sensor has potential applications in real-world structural health monitoring.
Review
Chemistry, Analytical
Linyi Wei, Yang Yu, Dongying Wang, Siyu Yao, Ning Li, Junjie Weng, Shumao Zhang, Jianqiao Liang, Hansi Ma, Junbo Yang, Zhenrong Zhang
Summary: The magnetic field is an important physical quantity closely related to human production and life. Fiber sensors based on the Magneto-Refractive Effect (MRE) have potential and significant application value in space detection, marine environmental monitoring, etc. This paper provides a brief summary of the present and prevalent Magneto-Refractive Magnetic Field Fiber Sensors (MR-MFSs) from the perspective of physicochemical properties, design methods, basic performance and properties, and key fabrication techniques, aiming to provide ideas and technical references for staff engaging in relevant research.
Article
Chemistry, Analytical
Shumao Zhang, Yang Yu, Xiaoyang Hu, Qiang Bian, Dongying Wang, Junjie Weng, Jianqiao Liang, Linyi Wei, Peng Jiang, Hong Luo, Linfeng Yang, Junbo Yang, Zhenrong Zhang
Summary: This paper proposes a method to improve sensitivity and solve the ill-conditioned matrix problem in SMM demodulation by optimizing the structure, and introduces the use of machine learning to improve demodulation accuracy. These findings have practical implications for developing an all-optical sensor for detection in the ocean environment.
Review
Medicine, General & Internal
Meiling Wang, Sihua Che, Weiwei Pan, Shumao Zhang, Guijun Shi
Summary: This study aims to explore the clinical efficacy of Xinmai'an tablets in treating premature ventricular contractions caused by CHD, providing evidence for treatment options.
Proceedings Paper
Computer Science, Artificial Intelligence
Shumao Zhang, Pengchuan Zhang, Thomas Y. Hou
Summary: MsIGN leverages multiscale structure to solve high-dimensional Bayesian inference, minimizing Jeffreys divergence through multistage training to avoid mode dropping, and demonstrating superior performance in high-dimensional scenarios.
INTERNATIONAL CONFERENCE ON MACHINE LEARNING, VOL 139
(2021)
Article
Genetics & Heredity
Tian Jianhai, Lv Jian, Zhang Long, Wang Wei, Zhang Shumao, Wang Yiming, Li Xiaojuan
Summary: The study found that the A allele of rs7975232 within the VDR gene, as well as the interaction between rs7975232 and smoking, were associated with an increased risk of renal cell carcinoma.
GENES AND ENVIRONMENT
(2021)
Article
Surgery
Shumao Zhang, Zhanwen Huang, Liang Cai, Wei Zhang, Haoyuan Ding, Li Zhang, Yue Chen
Summary: The study compared the effectiveness and safety of three-dimensional (3D) versus two-dimensional (2D) video-assisted hepatectomy for liver disease, and found that the 3D group had advantages in terms of operative time, intraoperative blood loss, blood transfusion volume, difference between predicted and actual resected volume, and postoperative complications rate.
VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
(2021)
