Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/ijms222312866
Keywords
extracellular vesicles; miR-122-5p; non-small cell lung cancer; RNA-binding protein
Funding
- National Natural Science Foundation of China [31871427, 81572447]
- Hubei Provincial Natural Science Foundation of China [2018CFB548]
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The study revealed that miR-122-5p is selectively sorted and secreted into lung cancer EVs through binding to RNA-binding protein hnRNPA2B1, promoting the migration of liver cells. This may contribute to establishing a pre-metastatic micro-environment and hepatic metastasis of lung cancer.
Extracellular vesicles (EVs) released by tumor cells play important roles on the remodeling of the tumor-stromal environment and on promoting tumor metastasis. Our earlier studies revealed that miR-122-5p, a type of small non-coding RNA, was dysregulated in non-small cell lung cancer (NSCLC) cell-derived EVs. In this study, we found that miR-122-5p was selectively sorted and secreted into lung cancer EVs through binding to RNA-binding protein hnRNPA2B1. In addition, we found that hnRNPA2B1 interacted with miR-122-5p through the EXO-motif. The delivering of lung cancer EVs-miR-122-5p promoted the migration of liver cells, which may play roles in establishing a pre-metastatic micro-environment and hepatic metastasis of lung cancer. Importantly, our findings revealed the molecular mechanism that RNA-binding protein controls the selective sorting of tumor-derived EV miR-122-5p, which potentially promotes lung cancer progression.
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