Genetically Determined Uric Acid and the Risk of Cardiovascular and Neurovascular Diseases: A Mendelian Randomization Study of Outcomes Investigated in Randomized Trials

MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank

(2018) Xue Li et al.   ANNALS OF THE RHEUMATIC DISEASES

Evaluating the potential role of pleiotropy in Mendelian randomization studies

(2018) Gibran Hemani et al.   HUMAN MOLECULAR GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Association between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging Study

(2018) Chun-Chin Chang et al.   Scientific Reports

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF CLINICAL NUTRITION

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

(2017) Stephen Burgess et al.   EPIDEMIOLOGY

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

(2017) Olena O Yavorska et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

(2017) J W Trampush et al.   MOLECULAR PSYCHIATRY

Evidence for Health Decision Making — Beyond Randomized, Controlled Trials

(2017) Thomas R. Frieden   NEW ENGLAND JOURNAL OF MEDICINE

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

(2017) Xue Li et al.   BMJ-British Medical Journal

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

(2017) Xue Li et al.   BMJ-British Medical Journal

Serum uric acid level and association with cognitive impairment and dementia: systematic review and meta-analysis

(2016) Aamir A. Khan et al.   AGE

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study

(2016) Isla S Mackenzie et al.   BMJ Open

Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants

(2016) Donald M. Lyall et al.   PLoS One

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Effects of Allopurinol on the Carotid Intima-media Thickness in Patients with Type 2 Diabetes and Asymptomatic Hyperuricemia: A Three-year Randomized Parallel-controlled Study

(2015) Peng Liu et al.   INTERNAL MEDICINE

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Uric Acid and Cardiovascular Events: A Mendelian Randomization Study

(2015) M. E. Kleber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Neuroprotective effects of urate are mediated by augmenting astrocytic glutathione synthesis and release

(2015) Rachit Bakshi et al.   NEUROBIOLOGY OF DISEASE

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study

(2013) Hilde M Storhaug et al.   BMC Cardiovascular Disorders

Calculating statistical power in Mendelian randomization studies

(2013) Marie-Jo A Brion et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Allopurinol Reduces Left Ventricular Mass in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy

(2013) Benjamin R. Szwejkowski et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function

(2013) Kim Hughes et al.   KIDNEY INTERNATIONAL

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

(2013) T. M. Palmer et al.   BMJ-British Medical Journal

Uric Acid Reduction Rectifies Prehypertension in Obese Adolescents

(2012) Beth Soletsky et al.   HYPERTENSION

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Use of Mendelian randomisation to assess potential benefit of clinical intervention

(2012) S. Burgess et al.   BMJ-British Medical Journal

Allopurinol Benefits Left Ventricular Mass and Endothelial Dysfunction in Chronic Kidney Disease

(2011) M. P. Kao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Using multiple genetic variants as instrumental variables for modifiable risk factors

(2011) Tom M Palmer et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial

(2010) Awsan Noman et al.   LANCET

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Assumptions of IV Methods for Observational Epidemiology

(2010) Vanessa Didelez et al.   STATISTICAL SCIENCE

Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension

(2008) Daniel I. Feig et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cerebral Ischemia Mediates the Effect of Serum Uric Acid on Cognitive Function

(2008) Tracy D. Vannorsdall et al.   STROKE

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE