“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a review

Demethylation of GFRA4 Promotes Cell Proliferation and Invasion in Hirschsprung Disease

(2018) Gang Wang et al.   DNA AND CELL BIOLOGY

Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing

(2018) Clara SM Tang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System

(2018) Fatima Memic et al.   GASTROENTEROLOGY

Identification of Genes Associated With Hirschsprung Disease, Based on Whole-Genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development

(2018) Clara Sze-man Tang et al.   GASTROENTEROLOGY

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function

(2017) Frank Pui-Ling Lai et al.   GASTROENTEROLOGY

Reversible RNA modifications in meiosis and pluripotency

(2017) Arne Klungland et al.   NATURE METHODS

Postnatal human enteric neuronal progenitors can migrate, differentiate, and proliferate in embryonic and postnatal aganglionic gut environments

(2017) Lily S. Cheng et al.   PEDIATRIC RESEARCH

Hirschsprung’s disease in twins: a systematic review and meta-analysis

(2017) D. Henderson et al.   PEDIATRIC SURGERY INTERNATIONAL

Enteric nervous system development: A crest cell’s journey from neural tube to colon

(2017) Nandor Nagy et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease

(2017) Leticia Villalba-Benito et al.   Scientific Reports

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells

(2017) Yuko Ueda et al.   Scientific Reports

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells

(2016) Rune Ougland et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

(2016) Alan J. Burns et al.   DEVELOPMENTAL BIOLOGY

Epigenetics in ENS development and Hirschsprung disease

(2016) A. Torroglosa et al.   DEVELOPMENTAL BIOLOGY

Regulators of gene expression in Enteric Neural Crest Cells are putative Hirschsprung disease genes

(2016) Duco Schriemer et al.   DEVELOPMENTAL BIOLOGY

Genetics of enteric neuropathies

(2016) Erwin Brosens et al.   DEVELOPMENTAL BIOLOGY

ALKBHs-facilitated RNA modifications and de-modifications

(2016) Endalkachew A. Alemu et al.   DNA REPAIR

Optimizing neurogenic potential of enteric neurospheres for treatment of neurointestinal diseases

(2016) Lily S. Cheng et al.   JOURNAL OF SURGICAL RESEARCH

Stem cells make the bowel nervous

(2016) Robert O. Heuckeroth   NATURE

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

(2016) Faranak Fattahi et al.   NATURE

The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

(2016) Dan Dominissini et al.   NATURE

Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome

(2016) Xiaoyu Li et al.   Nature Chemical Biology

In vivo transplantation of fetal human gut-derived enteric neural crest cells

(2016) J. E. Cooper et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Recent advances in regenerative medicine to treat enteric neuropathies: use of human cells

(2016) L. A. Stamp et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Hirschsprung’s disease: clinical dysmorphology, genes, micro-RNAs and future perspectives

(2016) Consolato Maria Sergi et al.   PEDIATRIC RESEARCH

miRNA Profiling Reveals Dysregulation of RET and RET-Regulating Pathways in Hirschsprung's Disease

(2016) Shuangshuang Li et al.   PLoS One

In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety

(2016) Julie E. Cooper et al.   PLoS One

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

(2015) A. Harikumar et al.   EMBO REPORTS

Applications of CRISPR–Cas systems in neuroscience

(2015) Matthias Heidenreich et al.   NATURE REVIEWS NEUROSCIENCE

Endoscopic delivery of enteric neural stem cells to treat Hirschsprung disease

(2015) L. S. Cheng et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Non-homologous functions of the AlkB homologs

(2015) Rune Ougland et al.   Journal of Molecular Cell Biology

The climate effect of increased forest bioenergy use in Sweden: evaluation at different spatial and temporal scales

(2015) Olivia Cintas et al.   Wiley Interdisciplinary Reviews-Energy and Environment

HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression

(2014) Joe Jiang Zhu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

HDAC1 and HDAC2 Control the Specification of Neural Crest Cells into Peripheral Glia

(2014) C. Jacob et al.   JOURNAL OF NEUROSCIENCE

Dynamic RNA Modifications in Posttranscriptional Regulation

(2014) Xiao Wang et al.   MOLECULAR CELL

Enteric nervous system development: migration, differentiation, and disease

(2013) Jonathan I. Lake et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Advances in Hirschsprung Disease Genetics and Treatment Strategies

(2013) Deepika D’Cunha Burkardt et al.   CLINICAL PEDIATRICS

Hirschsprung disease

(2013) Jacob C. Langer   CURRENT OPINION IN PEDIATRICS

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Transplanted progenitors generate functional enteric neurons in the postnatal colon

(2013) Ryo Hotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Down-regulation of MeCP2 in Hirschsprung's disease

(2013) Zhigang Zhou et al.   JOURNAL OF PEDIATRIC SURGERY

Neural stem cell therapies for enteric nervous system disorders

(2013) Alan J. Burns et al.   Nature Reviews Gastroenterology & Hepatology

Methylation analysis of EDNRB in human colon tissues of Hirschsprung’s disease

(2013) Weibing Tang et al.   PEDIATRIC SURGERY INTERNATIONAL

Distinct Functional and Temporal Requirements for Zebrafish Hdac1 during Neural Crest-Derived Craniofacial and Peripheral Neuron Development

(2013) Myron S. Ignatius et al.   PLoS One

Early progress in epigenetic regulation of endothelin pathway genes

(2012) AK Welch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Building a brain in the gut: development of the enteric nervous system

(2012) AM Goldstein et al.   CLINICAL GENETICS

Role of DNMT3B in the regulation of early neural and neural crest specifiers

(2012) Kristen Martins-Taylor et al.   Epigenetics

Formation and migration of neural crest cells in the vertebrate embryo

(2012) Marianne E. Bronner   HISTOCHEMISTRY AND CELL BIOLOGY

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Development and developmental disorders of the enteric nervous system

(2012) Florian Obermayr et al.   Nature Reviews Gastroenterology & Hepatology

Future therapies for Hirschsprung's disease

(2012) David J. Wilkinson et al.   Seminars in Pediatric Surgery

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

(2012) Yamei Niu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Stem cells for GI motility disorders

(2011) Ryo Hotta et al.   CURRENT OPINION IN PHARMACOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

(2011) Erwin van den Born et al.   Nature Communications

DNA methylation in stem cell renewal and multipotency

(2011) María Berdasco et al.   Stem Cell Research & Therapy

Differential Contributions of Rare and Common, Coding and Noncoding Ret Mutations to Multifactorial Hirschsprung Disease Liability

(2010) Eileen Sproat Emison et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5-Methoxycarbonylmethyluridine at the Wobble Position of tRNA

(2010) Ye Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation

(2010) M. Fu et al.   DEVELOPMENT

Functional outcome after operation for Hirschsprung disease—transanal vs transabdominal approach

(2010) Kjetil Juul Stensrud et al.   JOURNAL OF PEDIATRIC SURGERY

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

(2010) D. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Open chromatin in pluripotency and reprogramming

(2010) Alexandre Gaspar-Maia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mice Lacking Alkbh1 Display Sex-Ratio Distortion and Unilateral Eye Defects

(2010) Line M. Nordstrand et al.   PLoS One

Genetics of Hirschsprung disease and anorectal malformations

(2010) Erin Mundt et al.   Seminars in Pediatric Surgery

Enteric Nervous System Stem Cells Derived From Human Gut Mucosa for the Treatment of Aganglionic Gut Disorders

(2009) Marco Metzger et al.   GASTROENTEROLOGY

Epigenetic control of skull morphogenesis by histone deacetylase 8

(2009) M. Haberland et al.   GENES & DEVELOPMENT

Development of enteric neuron diversity

(2009) Marlene M. Hao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Properties of secondary and tertiary human enteric nervous system neurospheres

(2009) Richard M. Lindley et al.   JOURNAL OF PEDIATRIC SURGERY

Evolution of the neural crest viewed from a gene regulatory perspective

(2008) Tatjana Sauka-Spengler et al.   GENESIS

colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis

(2007) Myron S. Ignatius et al.   DEVELOPMENTAL BIOLOGY