Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity

(2019) John D. Clarke et al.   TOXICON

Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease

(2019) Sutapa Sarkar et al.   Scientific Reports

Exposure to the Harmful Algal Bloom (HAB) Toxin Microcystin-LR (MC-LR) Prolongs and Increases Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis

(2019) Robin C. Su et al.   Toxins

Chronic exposure of nanomolar MC-LR caused oxidative stress and inflammatory responses in HepG2 cells

(2018) Junguo Ma et al.   CHEMOSPHERE

An overview of the accumulation of microcystins in aquatic ecosystems

(2018) Thanh-Luu Pham et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Low level Hg 2+ exposure modulates the B-cell cytoskeletal phosphoproteome

(2018) Nicholas J. Carruthers et al.   Journal of Proteomics

Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins

(2018) Evanthia Mantzouki et al.   Toxins

Development and applications of solid-phase extraction and liquid chromatography-mass spectrometry methods for quantification of microcystins in urine, plasma, and serum

(2018) Dilrukshika S.W. Palagama et al.   JOURNAL OF CHROMATOGRAPHY A

Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis

(2017) Yabing Chen et al.   ENVIRONMENTAL POLLUTION

Microcystin exposure Exacerbates Non-alcoholic Fatty Liver Disease (NAFLD) via NOX2 Dependent Activation of miR21-induced Inflammatory Pathways

(2017) Muayad Albadrani et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Toxic mechanisms of microcystins in mammals

(2017) Nicole L. McLellan et al.   Toxicology Research

Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States

(2017) Michael H. Le et al.   PLoS One

Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study

(2016) Jun He et al.   ARCHIVES OF TOXICOLOGY

Global solutions to regional problems: Collecting global expertise to address the problem of harmful cyanobacterial blooms. A Lake Erie case study

(2016) George S. Bullerjahn et al.   HARMFUL ALGAE

Comprehensive insights into microcystin-LR effects on hepatic lipid metabolism using cross-omics technologies

(2016) Zongyao Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances

(2016) Jennie Ka Ching Lau et al.   JOURNAL OF PATHOLOGY

Epidemiology and natural history of non-alcoholic fatty liver disease

(2016) Yousef Fazel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2016) Gregory Thomas Brown et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

New Insights on the Mode of Action of Microcystins in Animal Cells - A Review

(2016) Elisabete Valério et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis

(2016) Liang Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Hepatic and intestine alterations in mice after prolonged exposure to low oral doses of Microcystin-LR

(2015) Daniela Sedan et al.   TOXICON

Identification and Expression Profiles of IL-8 in Bighead Carp (Aristichthys nobilis) in Response to Microcystin-LR

(2013) Huiying Li et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods

(2013) Leif Väremo et al.   NUCLEIC ACIDS RESEARCH

Microcystin-LR Exhibits Immunomodulatory Role in Mouse Primary Hepatocytes Through Activation of the NF-κB and MAPK Signaling Pathways

(2013) Jianying Zhang et al.   TOXICOLOGICAL SCIENCES

Biomarkers of prolonged exposure to microcystin-LR in mice

(2013) Daniela Sedan et al.   TOXICON

Appearance of Planktothrix rubescens Bloom with [D-Asp3, Mdha7]MC–RR in Gravel Pit Pond of a Shallow Lake-Dominated Area

(2013) Gábor Vasas et al.   Toxins

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Microcystin–LR causes cytotoxicity effects in rat testicular Sertoli cells

(2011) Yan Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Molecular Mechanisms of Microcystin Toxicity in Animal Cells

(2010) Alexandre Campos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Aspects of Microcystin-induced Hepatotoxicity and Hepatocarcinogenesis

(2010) Z. Svirčev et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

First Identification of the Hepatotoxic Microcystins in the Serum of a Chronically Exposed Human Population Together with Indication of Hepatocellular Damage

(2009) Jun Chen et al.   TOXICOLOGICAL SCIENCES

Differential oxidative stress responses to pure Microcystin-LR and Microcystin-containing and non-containing cyanobacterial crude extracts on Caco-2 cells

(2009) María Puerto et al.   TOXICON

In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit

(2008) Yanyan Zhao et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Defects in Innate Immunity Predispose C57BL/6J-Leprdb/Leprdb Mice to Infection by Staphylococcus aureus

(2008) S. Park et al.   INFECTION AND IMMUNITY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Hepatic recovery after damage produced by sub-chronic intoxication with the cyanotoxin microcystin LR

(2007) Darío Andrinolo et al.   TOXICON