Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis

Mining Filarial Genomes for Diagnostic and Therapeutic Targets

(2018) Sasisekhar Bennuru et al.   TRENDS IN PARASITOLOGY

Alternative treatment strategies to accelerate the elimination of onchocerciasis

(2018) Michel Boussinesq et al.   International Health

The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans

(2018) Pauline Fontaine et al.   International Journal for Parasitology-Drugs and Drug Resistance

A Trial of a Triple-Drug Treatment for Lymphatic Filariasis

(2018) Christopher L. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae

(2017) Sweta Misra et al.   Parasites & Vectors

Ivermectin treatment of Loa loa hyper-microfilaraemic baboons (Papio anubis): Assessment of microfilarial load reduction, haematological and biochemical parameters and histopathological changes following treatment

(2017) Samuel Wanji et al.   PLoS Neglected Tropical Diseases

Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults

(2017) David J. Diemert et al.   PLoS Neglected Tropical Diseases

RNAi-mediated gene knockdown by microinjection in the model entomopathogenic nematode Heterorhabditis bacteriophora

(2016) Ramesh Ratnappan et al.   Parasites & Vectors

Identification and Validation of Loa loa Microfilaria-Specific Biomarkers: a Rational Design Approach Using Proteomics and Novel Immunoassays

(2016) Papa M. Drame et al.   mBio

A Proteomic Analysis of the Body Wall, Digestive Tract, and Reproductive Tract of Brugia malayi

(2015) C. Paul Morris et al.   PLoS Neglected Tropical Diseases

Understanding Hidden Antigens and Targeting Parasitic Nematodes

(2015) Sasisekhar Bennuru   EBioMedicine

Mechanosensitive unpaired innexin channels in C. elegans touch neurons

(2014) Rachele Sangaletti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phenobarbital Induction and Chemical Synergism Demonstrate the Role of UDP-Glucuronosyltransferases in Detoxification of Naphthalophos by Haemonchus contortus Larvae

(2014) Andrew C. Kotze et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Uricosuric drugs

(2014) Mary H. Bach et al.   CURRENT OPINION IN RHEUMATOLOGY

Innexin and pannexin channels and their signaling

(2014) Gerhard Dahl et al.   FEBS LETTERS

Progress and Impact of 13 Years of the Global Programme to Eliminate Lymphatic Filariasis on Reducing the Burden of Filarial Disease

(2014) K. D. Ramaiah et al.   PLoS Neglected Tropical Diseases

The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

(2013) Andrew Rowland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Biotransformation of albendazole and activities of selected detoxification enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics

(2013) Ivan Vokřál et al.   VETERINARY PARASITOLOGY

In vitro gene silencing of independent phosphoglycerate mutase (iPGM) in the filarial parasite Brugia malayi

(2013) Prashant Kumar Singh et al.   Infectious Diseases of Poverty

Transcription profiling reveals stage- and function-dependent expression patterns in the filarial nematode Brugia malayi

(2012) Ben-Wen Li et al.   BMC GENOMICS

Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths

(2012) David J. Diemert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics

(2012) IVAN VOKŘÁL et al.   PARASITOLOGY

Considering RNAi experimental design in parasitic helminths

(2012) JOHNATHAN J. DALZELL et al.   PARASITOLOGY

In Vitro Silencing of Brugia malayi Trehalose-6-Phosphate Phosphatase Impairs Embryogenesis and In Vivo Development of Infective Larvae in Jirds

(2012) Susheela Kushwaha et al.   PLoS Neglected Tropical Diseases

The History and Future of Probenecid

(2011) Nathan Robbins et al.   Cardiovascular Toxicology

Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus

(2011) C. C. BASSETTO et al.   PARASITE IMMUNOLOGY

Stage-specific proteomic expression patterns of the human filarial parasite Brugia malayi and its endosymbiont Wolbachia

(2011) S. Bennuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections

(2010) Sasisekhar Bennuru et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Characterization of the xenobiotic response ofCaenorhabditis elegansto the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites

(2010) Steven T. Laing et al.   BIOCHEMICAL JOURNAL

Elimination of lymphatic filariasis: do we have the drugs to complete the job?

(2010) Moses J Bockarie et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Molecular Cloning, Biochemical Characterization, and Partial Protective Immunity of the Heme-Binding Glutathione S-Transferases from the Human Hookworm Necator americanus

(2010) B. Zhan et al.   INFECTION AND IMMUNITY

Neutralizing Antibodies to the Hookworm HemoglobinaseNa‐APR‐1: Implications for a Multivalent Vaccine against Hookworm Infection and Schistosomiasis

(2010) Mark S. Pearson et al.   JOURNAL OF INFECTIOUS DISEASES

Deleterious Effects of Reactive Metabolites

(2010) Sabry M. Attia   Oxidative Medicine and Cellular Longevity

An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

(2009) Mark S. Pearson et al.   FASEB JOURNAL

Probenecid, a gout remedy, inhibits pannexin 1 channels

(2008) William Silverman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Rapid, Novel, Specific, High-Throughput Assay for Diagnosis of Loa loa Infection

(2008) P. D. Burbelo et al.   JOURNAL OF CLINICAL MICROBIOLOGY