Article
Biochemistry & Molecular Biology
Jiayi Sun, Wing-Yuk Chow, Gufeng Xu, M. John Hicks, Manjula Nakka, Jianhe Shen, Patrick Kwok Shing M. Ng, Aaron Taylor, Alexander E. Yu, Jason A. Farrar, Donald Barkauskas, Richard M. Gorlick, Jaime M. Guidry Auvil, Daniela Gerhard, Paul Meltzer, Rudy Guerra, Tsz-Kwong C. Man, Ching Lau, TARGET Osteosarcoma Consortium
Summary: Osteosarcoma is a primary malignant bone tumor that commonly metastasizes to the lungs. Altered FAS expression due to DNA methylation has been explored as a mechanism in cancer cells. Analysis revealed high variability in methylation of CpG sites that correlated with FAS mRNA expression. Treatment with demethylating agent 5-azacytidine restored FAS protein expression and reduced metastasis in osteosarcoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Bhaba K. Das, Lei Wang, Toshifumi Fujiwara, Jian Zhou, Nukhet Aykin-Burns, Kimberly J. Krager, Renny Lan, Samuel G. Mackintosh, Ricky Edmondson, Michael L. Jennings, Xiaofang Wang, Jian Q. Feng, Tomasa Barrientos, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao
Summary: Increased intracellular iron through Tfr1-mediated iron uptake is essential for mitochondrial metabolism and cytoskeletal organization in osteoclasts, leading to proper bone resorption and skeletal homeostasis.
Article
Oncology
Chujie Bai, Xiuli Ma, Xinyu Wang, Xiaoya Chen
Summary: This study analyzed the pathological features of osteosarcoma patients and the expression of TfR1, VEGF, and MMP-9 in tumor tissue, and found significant correlations with the pathological features. The abnormal expressions of TfR1, VEGF, and MMP-9 suggest their involvement in the occurrence and development of osteosarcoma.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Nicole Bodmer, Stefanie Hecker-Nolting, Godehard Friedel, Claudia Blattmann, Leo Kager, Torsten Kessler, Matthias Kevric Dok, Thomas Kuhne, Vanessa Mettmann, Peter Mueller-Abt, Benjamin Sorg, Matthias Theobald, Stefan S. Bielack
Summary: This study analyzed the clinical characteristics and optimal therapeutic strategies for primary rib osteosarcoma. The results showed that surgery and chemotherapy played a key role in treatment, but negative prognostic factors included incomplete tumor surgery, osteoblastic histology, and poor response to chemotherapy. Early diagnosis and effective local control are crucial for better outcomes.
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
Summary: By disrupting the expression of the Tf receptor gene in oligodendrocyte progenitor cells, researchers found that the Tf cycle is uniquely important for the development and function of oligodendrocytes. Deleting the Tfr gene resulted in impaired iron absorption and hypomyelination in mice. The Tf cycle plays a crucial role in iron homeostasis and energy production in oligodendrocyte progenitor cells.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Isabella Lurje, Nadine Therese Gaisa, Edgar Dahl, Ruth Knuechel, Pavel Strnad, Christian Trautwein, Frank Tacke, Ulf Peter Neumann, Zoltan Czigany, Georg Lurje
Summary: This study analyzed the association between 11 genetic variants related to tumor-promoting inflammation and disease-free and overall survival in iCCA patients undergoing surgery. The IL-1B +3954 C/C and IL-8 -251 T/A or A/A genotypes were found to be associated with shorter overall survival.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Yanqi Ma, Qikai Zhou, Pingping Zhao, Xiaoyu Lv, Caixia Gong, Jie Gao, Jingfang Liu
Summary: This study observed the glycation degree and sites of transferrin induced by different concentrations of high glucose, and investigated the effects of high glucose on human renal tubular epithelial cells. The results showed that the glycation degree of transferrin increased with high glucose stimulation, but the binding capacity with iron decreased. Additionally, in vitro stimulation of HK-2 cells with AGE-Tf led to increased cell apoptosis, decreased antioxidant capacity, and downregulated TfR expression levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Hematology
O. Yaw Addo, Zuguo Mei, Eldad A. Hod, Maria Elena Jefferds, Andrea J. Sharma, Rafael C. Flores-Ayala, Steven L. Spitalnik, Gary M. Brittenham
Summary: The study aimed to develop a physiologically based method to determine serum ferritin thresholds for iron deficiency in healthy individuals, specifically focusing on women aged 20 to 49 years. Results indicated that serum ferritin levels below a certain threshold were associated with iron-deficient erythropoiesis, as seen through the levels of soluble transferrin receptor and hemoglobin.
Article
Biochemistry & Molecular Biology
Jenny Jin, Kenji Schorpp, Daniel Samaga, Kristian Unger, Kamyar Hadian, Brent R. Stockwell
Summary: A machine learning approach combined with staining techniques was developed to unbiasedly classify different cell death mechanisms based on specific cell features, providing a novel analytic framework.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soon-Young Jung, Hyun Kyoung Lee, Hyungmin Kim, Seulki Kim, Jung Soo Kim, Jeong Gu Kang, Hyo-Jeong Kuh, Jong Shin Yoo, Jeong-Heon Ko, Jeong-Hwa Lee
Summary: Alterations in sialylation of terminal residues of glycoproteins have been implicated in forming tumor associated glycans. The impact of ST6GALNACIII on tumor progression remains undefined. ST6GALNACIII plays an important role in promoting A549 cell growth through quantitative regulation of TFR1 expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Yuanmeng Ma, Ruike Li, Yixin Dong, Chaoqun You, Shenlin Huang, Xun Li, Fei Wang, Yu Zhang
Summary: The study demonstrated that by functionalizing tLyP-1 at the N-terminal of ferritin, there was enhanced intracellular delivery of PTX, better cytotoxicity, and anti-invasion capability against both MDA-MB-231 and SMMC-7721 cells. Improved penetrability and growth inhibitory effects on SMMC-7721 tumor spheroids were also observed.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Medical Laboratory Technology
Chuanhui Xun, Dawei Jiang, Zheng Tian, Akbar Yunus, Jiangtao Chen
Summary: Long noncoding RNA PVT1 is upregulated in osteosarcoma, with high expression correlating with poor prognosis in patients. Knockdown of lncRNA PVT1 in vitro inhibits the proliferation, migration, and invasion ability of osteosarcoma cells. These findings suggest that lncRNA PVT1 could be a potential therapeutic target for osteosarcoma.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Immunology
Pierre V. Candelaria, Lai Sum Leoh, Manuel L. Penichet, Tracy R. Daniels-Wells
Summary: TfR1, also known as CD71, plays a critical role in cellular iron uptake by binding to transferrin. Its overexpression in malignant cells is associated with poor prognosis in different types of cancer. Targeting TfR1 with antibodies has shown potential as a direct anti-tumor therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Duo Zeng, Jiayu Li, Xuhui Yuan, Feng Cai, Bo Yu, Lang Liu, Qinchan Chen, FeiFei Zhang, Yiping Liang, Xiaofeng Tang, Yuanxiang Peng, Gaoyang Qu, Pengyun Wu, QuanHui Jiao, Longhua Sun, Xiao-Bin Lv, Qi Liao
Summary: In this study, we identified the prognostic factor FKBP11 closely associated with osteosarcoma through the analysis of patient data from GTEx and TARGET databases, and developed a risk model. The expression of FKBP11 was found to be high in osteosarcoma, and silencing its expression inhibited invasion and migration of osteosarcoma cells, slowed cell proliferation, and promoted apoptosis. We also discovered a novel mechanism by which FKBP11 ameliorates the malignant properties of osteosarcoma cells through the MAPK pathway. This study provides a new method for the treatment of osteosarcoma.
Review
Cell Biology
Yun Liu, Nenggan Huang, Shijie Liao, Emel Rothzerg, Felix Yao, Yihe Li, David Wood, Jiake Xu
Summary: Osteosarcoma is the most common primary malignant bone tumor, with incidence peaking during adolescence. Despite improvements in prognosis with the introduction of neoadjuvant chemotherapy, outcomes have not significantly improved since then. Novel therapeutic strategies are urgently needed as an adjunct to conventional treatment modalities to improve outcomes for patients with osteosarcoma.
CELL PROLIFERATION
(2021)
