Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions

(2019) Clara Bueno et al.   HAEMATOLOGICA

Label-Free Quantitative Proteomics in a Methylmalonyl-CoA Mutase-Silenced Neuroblastoma Cell Line

(2018) Michele Costanzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia

(2017) Hiroshi Okuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear localization of Formyl-Peptide Receptor 2 in human cancer cells

(2016) Fabio Cattaneo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cell source determines the immunological impact of biomimetic nanoparticles

(2016) Michael Evangelopoulos et al.   BIOMATERIALS

TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription

(2016) Hiroshi Okuda et al.   CELL CYCLE

The role of the 14-3-3 protein family in health, disease, and drug development

(2016) Yasaman Aghazadeh et al.   DRUG DISCOVERY TODAY

Deregulation of HOX genes by DNMT3A and MLL mutations converges on BMI1

(2016) Y-T Tan et al.   LEUKEMIA

Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM)

(2016) Anca Margineanu et al.   Scientific Reports

The proteome of cblC defect: in vivo elucidation of altered cellular pathways in humans

(2015) Marianna Caterino et al.   JOURNAL OF INHERITED METABOLIC DISEASE

AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription

(2015) Hiroshi Okuda et al.   Nature Communications

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199

(2015) Juliana M. Benito et al.   Cell Reports

A systematic description of MLL fusion gene formation

(2014) Rebecca L. Wright et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Insulin-like growth factor 1 receptor signaling induced by supraphysiological doses of IGF-1 in human peripheral blood lymphocytes

(2014) Sara Spaziani et al.   PROTEOMICS

Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms

(2011) Gabriella Esposito et al.   BIOCHEMICAL JOURNAL

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation

(2011) K. Orlovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatic and experimental survey of 14-3-3-binding sites

(2010) Catherine Johnson et al.   BIOCHEMICAL JOURNAL

Mechanisms of leukemogenesis by MLL fusion proteins

(2010) Rolf Marschalek   BRITISH JOURNAL OF HAEMATOLOGY

A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

(2010) Akihiko Yokoyama et al.   CANCER CELL

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT

(2010) A Gessner et al.   LEUKEMIA

A Robust Protocol to Map Binding Sites of the 14-3-3 Interactome: Cdc25C Requires Phosphorylation of Both S216 and S263 to bind 14-3-3

(2010) Perry M. Chan et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

(2009) R. W. Stam et al.   BLOOD

14-3-3 Ligand Prevents Nuclear Import of c-ABL Protein in Chronic Myeloid Leukemia

(2009) Manuela Mancini et al.   TRAFFIC

14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr

(2008) Diane L Bolton et al.   Biology Direct

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

(2008) M. G. Guenther et al.   GENES & DEVELOPMENT

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL