Trisomy 8 in acute myeloid leukemia

Targeting FLT3 mutations in AML: review of current knowledge and evidence

(2019) Naval Daver et al.   LEUKEMIA

Myeloid Sarcoma

(2019) Mohamed Magdy et al.   Oncology Research and Treatment

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

(2019) Jonas Samuel Jutzi et al.   BLOOD

Autologous Hematopoietic Stem Cell Transplantation in Acute Myelogenous Leukemia

(2019) Yuanqi Zhao et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The assessment of minimal residual disease versus that of somatic mutations for predicting the outcome of acute myeloid leukemia patients

(2019) Serena Salehzadeh et al.   Cancer Cell International

Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party

(2018) Gerrit J. Schuurhuis et al.   BLOOD

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature

(2018) Anne Dorte Lerche Espersen et al.   GENES CHROMOSOMES & CANCER

CPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia

(2018) Jeffrey E. Lancet et al.   JOURNAL OF CLINICAL ONCOLOGY

ASXL1 mutations in AML are associated with specific clinical and cytogenetic characteristics

(2018) Katerina Kakosaiou et al.   LEUKEMIA & LYMPHOMA

Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group

(2018) Sanne Noort et al.   BLOOD

Inflammatory disorders associated with trisomy 8-myelodysplastic syndromes: French retrospective case-control study

(2018) Nadege Wesner et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Aplastic anemia: etiology, molecular pathogenesis and emerging concepts

(2018) Rory M Shallis et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

New approaches in allogenic transplantation in AML

(2018) Xuying Pei et al.   SEMINARS IN HEMATOLOGY

Classification and Personalized Prognosis in Myeloproliferative Neoplasms

(2018) Jacob Grinfeld et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry

(2017) Vladimir Lj Lazarevic et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Number of RUNX1 mutations, wild-type allele loss and additional mutations impact on prognosis in adult RUNX1-mutated AML

(2017) A Stengel et al.   LEUKEMIA

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Trisomy 8 in pediatric acute myeloid leukemia: A NOPHO-AML study

(2016) Anne Cathrine Lund Laursen et al.   GENES CHROMOSOMES & CANCER

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBP  as a common target of TRIB1 and PML/RARA

(2016) K. Keeshan et al.   HAEMATOLOGICA

Erratum: RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features

(2016) V I Gaidzik et al.   LEUKEMIA

NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis

(2016) S Struski et al.   LEUKEMIA

Isocitrate dehydrogenase mutations in myeloid malignancies

(2016) B C Medeiros et al.   LEUKEMIA

ASXL1 mutations are frequent in de novo AML with trisomy 8 and confer an unfavorable prognosis

(2016) Xiangping Zong et al.   LEUKEMIA & LYMPHOMA

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Prognostic Factors in 86 Chinese Patients with Primary Myelodysplastic Syndromes and Trisomy 8: A Single Institution Experience

(2016) Qing-Fang Yue et al.   YONSEI MEDICAL JOURNAL

Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBP  as a common target of TRIB1 and PML/RARA

(2016) K. Keeshan et al.   HAEMATOLOGICA

Acute Myeloid Leukemia With Myelodysplasia-Related Changes

(2015) James Vardiman et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia

(2015) Vladimir Lazarevic et al.   AMERICAN JOURNAL OF HEMATOLOGY

Impact of trisomy 8 on treatment response and survival of patients with chronic myelogenous leukemia in the era of tyrosine kinase inhibitors

(2015) W Wang et al.   LEUKEMIA

AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients

(2015) Tamara Alpermann et al.   LEUKEMIA RESEARCH

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution

(2015) H-A Hou et al.   Blood Cancer Journal

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation

(2014) R. F. Schlenk et al.   BLOOD

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis

(2014) T. Herold et al.   BLOOD

How I treat the older patient with acute myeloid leukemia

(2014) G. Ossenkoppele et al.   BLOOD

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

(2014) R. C. Lindsley et al.   BLOOD

Expression profiling of leukemia patients: Key lessons and future directions

(2014) Velizar Shivarov et al.   EXPERIMENTAL HEMATOLOGY

CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients

(2014) A Tefferi et al.   LEUKEMIA

Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8

(2014) H Becker et al.   LEUKEMIA

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome

(2014) T-C Chen et al.   Blood Cancer Journal

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

(2012) A. F. T. Ribeiro et al.   BLOOD

A novel hierarchical prognostic model of AML solely based on molecular mutations

(2012) V. Grossmann et al.   BLOOD

Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes

(2012) Sílvia Saumell et al.   BRITISH JOURNAL OF HAEMATOLOGY

Image cytometry-based detection of aneuploidy by fluorescence in situ hybridization in suspension

(2012) Hans Minderman et al.   CYTOMETRY PART A

Trisomy 8 in myeloid leukemia cutis confirmed by fluorescencein situhybridization analysis

(2012) Marianna Shvartsbeyn et al.   JOURNAL OF CUTANEOUS PATHOLOGY

ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome

(2012) S Schnittger et al.   LEUKEMIA

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

(2012) Jay P. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study

(2011) E. A. Coenen et al.   BLOOD

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

(2011) F. G. Rucker et al.   BLOOD

TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

(2011) W.-C. Chou et al.   BLOOD

Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia

(2011) Tim Ripperger et al.   BRITISH JOURNAL OF HAEMATOLOGY

Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications

(2011) Håkon Reikvam et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Dysregulation of Gene Expression in the Artificial Human Trisomy Cells of Chromosome 8 Associated with Transformed Cell Phenotypes

(2011) Hisakatsu Nawata et al.   PLoS One

Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations

(2010) W.-C. Chou et al.   BLOOD

The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML

(2010) S. Kayser et al.   BLOOD

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

(2010) S. Schnittger et al.   BLOOD

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials

(2010) D. Grimwade et al.   BLOOD

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

Cytogenetic risk stratification in chronic myelomonocytic leukemia

(2010) E. Such et al.   HAEMATOLOGICA

Extramedullary Relapse of AML with t(9;11)(p22;q23) Associated with Clonal Evolution from Trisomy 8 into Tetrasomy 8

(2010) Tohru Takahashi et al.   INTERNAL MEDICINE

Prognosis of Secondary Acute Myeloid Leukemia is Affected by the Type of the Preceding Hematologic Disorders and the Presence of Trisomy 8

(2010) Y. Koh et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

(2010) C H Kok et al.   LEUKEMIA

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

(2010) W-C Chou et al.   LEUKEMIA

IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia

(2010) D Caramazza et al.   LEUKEMIA

Differential cytogenomics and miRNA signature of the Acute Myeloid Leukaemia Kasumi-1 cell line CD34+38− compartment

(2010) Laura Pedranzini et al.   LEUKEMIA RESEARCH

Integrative Meta-Analysis of Differential Gene Expression in Acute Myeloid Leukemia

(2010) Brady G. Miller et al.   PLoS One

DNA Methylation Profiles and Their Relationship with Cytogenetic Status in Adult Acute Myeloid Leukemia

(2010) Sara Alvarez et al.   PLoS One

Quantitative DNA methylation predicts survival in adult acute myeloid leukemia

(2009) L. Bullinger et al.   BLOOD

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations

(2009) J.-L. Tang et al.   BLOOD

Outcome after allogeneic transplantation for adult acute myeloid leukemia patients exhibiting isolated or associated trisomy 8 chromosomal abnormality: a survey on behalf of the ALWP of the EBMT

(2009) P Chevallier et al.   BONE MARROW TRANSPLANTATION

Constitutional aneuploidy and cancer predisposition

(2009) I. Ganmore et al.   HUMAN MOLECULAR GENETICS

Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias

(2009) N Carbuccia et al.   LEUKEMIA

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia

(2008) R. Garzon et al.   BLOOD

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

(2008) M. Jongen-Lavrencic et al.   BLOOD

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

(2008) R. G.W. Verhaak et al.   HAEMATOLOGICA

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA