TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma

Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy via STAT3

(2019) Puglisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

(2018) Kyohei Nakamura et al.   CANCER CELL

PMN-MDSC and arginase are increased in myeloma and may contribute to resistance to therapy

(2018) Alessandra Romano et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis

(2018) Nicola Graham et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting cancer-related inflammation in the era of immunotherapy

(2017) Kyohei Nakamura et al.   IMMUNOLOGY AND CELL BIOLOGY

A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy

(2016) J. Lin et al.   BLOOD

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model

(2016) Antonio Sacco et al.   CANCER RESEARCH

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review)

(2016) Xu Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma

(2016) Marilène Binsfeld et al.   Oncotarget

Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC)

(2016) Cesarina Giallongo et al.   Oncotarget

Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of Macrophages

(2016) Esha Mathew et al.   NEOPLASIA

Mesenchymal Stem Cells (MSC) Regulate Activation of Granulocyte-Like Myeloid Derived Suppressor Cells (G-MDSC) in Chronic Myeloid Leukemia Patients

(2016) Cesarina Giallongo et al.   PLoS One

TLR4 plays a crucial role in MSC-induced inhibition of NK cell function

(2015) Ying Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma

(2015) Megan Y Murray et al.   CELL CYCLE

Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis

(2015) Christophe Desterke et al.   MEDIATORS OF INFLAMMATION

Myeloid Derived Suppressor Cells in Chronic Myeloid Leukemia

(2015) Cesarina Giallongo et al.   Frontiers in Oncology

An in vitro retinoblastoma human triple culture model of angiogenesis: A modulatory effect of TGF-β

(2014) Gabriella Lupo et al.   CANCER LETTERS

Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency

(2014) Norimasa Iwanami   EXPERIMENTAL HEMATOLOGY

Stimulation of mesenchymal stromal cells (MSCs) via TLR3 reveals a novel mechanism of autocrine priming

(2014) Claudia A. Dumitru et al.   FASEB JOURNAL

Targeting the bone marrow microenvironment in multiple myeloma

(2014) Yawara Kawano et al.   IMMUNOLOGICAL REVIEWS

Myeloid Derived Suppressor Cells (MDSCs) Are Increased and Exert Immunosuppressive Activity Together with Polymorphonuclear Leukocytes (PMNs) in Chronic Myeloid Leukemia Patients

(2014) Cesarina Giallongo et al.   PLoS One

Adequate Th2-Type Response Associates with Restricted Bacterial Growth in Latent Mycobacterial Infection of Zebrafish

(2014) Milka Marjut Hammarén et al.   PLoS Pathogens

Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans

(2013) G. T. Gorgun et al.   BLOOD

Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

(2013) Moshe Sade-Feldman et al.   IMMUNITY

Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies

(2013) M A Frassanito et al.   LEUKEMIA

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Mesenchymal stem cell signaling in cancer progression

(2012) Anja Torsvik et al.   CANCER TREATMENT REVIEWS

Molecular Pathways: Tumor-Infiltrating Myeloid Cells and Reactive Oxygen Species in Regulation of Tumor Microenvironment

(2012) T. Lu et al.   CLINICAL CANCER RESEARCH

Essential Role of IL-4 and IL-4R  Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates

(2012) L.-y. Zhu et al.   JOURNAL OF IMMUNOLOGY

Mesenchymal Stem Cell 1 (MSC1)-Based Therapy Attenuates Tumor Growth Whereas MSC2-Treatment Promotes Tumor Growth and Metastasis

(2012) Ruth S. Waterman et al.   PLoS One

Toll-Like Receptors as Modulators of Mesenchymal Stem Cells

(2012) Olga DelaRosa et al.   Frontiers in Immunology

BRIT1/MCPH1 Expression in Chronic Myeloid Leukemia and Its Regulation of the G2/M Checkpoint

(2011) C. Giallongo et al.   ACTA HAEMATOLOGICA

Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

(2011) Melissa G Lechner et al.   Journal of Translational Medicine

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Stem Cells Protect Breast Cancer Cells through Regulatory T Cells: Role of Mesenchymal Stem Cell-Derived TGF- 

(2010) S. A. Patel et al.   JOURNAL OF IMMUNOLOGY

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

(2010) N. Matsunaga et al.   MOLECULAR PHARMACOLOGY

Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish

(2010) Francisco J. Quintana et al.   PLoS One

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

Dissection of Organs from the Adult Zebrafish

(2010) Tripti Gupta et al.   Jove-Journal of Visualized Experiments

Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis

(2009) Wen-ting Xu et al.   CANCER LETTERS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Toll-Like Receptors on Human Mesenchymal Stem Cells Drive Their Migration and Immunomodulating Responses

(2007) Suzanne L. Tomchuck et al.   STEM CELLS