Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

(2019) Laura Gomez-Valero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effector repertoire of Legionella

(2019) Andrea Du Toit   NATURE REVIEWS MICROBIOLOGY

Legionella qingyii sp. nov., isolated from water samples in China

(2019) Hai-Yan Wu et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

New paradigm in ankyrin repeats: Beyond protein-protein interaction module

(2018) Zeyaul Islam et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Factors Mediating Environmental Biofilm Formation by Legionella pneumophila

(2018) Arwa Abu Khweek et al.   Frontiers in Cellular and Infection Microbiology

The Toolbox for Uncovering the Functions of Legionella Dot/Icm Type IVb Secretion System Effectors: Current State and Future Directions

(2018) Gunnar N. Schroeder   Frontiers in Cellular and Infection Microbiology

Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection

(2018) A. Leoni Swart et al.   Frontiers in Cellular and Infection Microbiology

The Life Cycle of L. pneumophila: Cellular Differentiation Is Linked to Virulence and Metabolism

(2018) Giulia Oliva et al.   Frontiers in Cellular and Infection Microbiology

The Legionella Effector Kinase LegK7 Hijacks the Host Hippo Pathway to Promote Infection

(2018) Pei-Chung Lee et al.   Cell Host & Microbe

Evasion of phagotrophic predation by protist hosts and innate immunity of metazoan hosts by Legionella pneumophila

(2018) Ashley M. Best et al.   CELLULAR MICROBIOLOGY

Evolution of the Arsenal of Legionella pneumophila Effectors To Modulate Protist Hosts

(2018) Ashley Best et al.   mBio

Legionella and Coxiella effectors: strength in diversity and activity

(2017) Jiazhang Qiu et al.   NATURE REVIEWS MICROBIOLOGY

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database

(2017) Neil D Rawlings et al.   NUCLEIC ACIDS RESEARCH

Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

(2017) Aimin Yang et al.   eLife

Host FIH-Mediated Asparaginyl Hydroxylation of Translocated Legionella pneumophila Effectors

(2017) Christopher Price et al.   Frontiers in Cellular and Infection Microbiology

Formation of the Legionella Replicative Compartment at the Crossroads of Retrograde Trafficking

(2017) Kevin Bärlocher et al.   Frontiers in Cellular and Infection Microbiology

Beyond Paralogs: The Multiple Layers of Redundancy in Bacterial Pathogenesis

(2017) Soma Ghosh et al.   Frontiers in Cellular and Infection Microbiology

Hijacking of the Host Ubiquitin Network by Legionella pneumophila

(2017) Jiazhang Qiu et al.   Frontiers in Cellular and Infection Microbiology

From Many Hosts, One Accidental Pathogen: The Diverse Protozoan Hosts of Legionella

(2017) David K. Boamah et al.   Frontiers in Cellular and Infection Microbiology

Legionella pneumophila, armed to the hilt: justifying the largest arsenal of effectors in the bacterial world

(2016) Alexander W Ensminger   CURRENT OPINION IN MICROBIOLOGY

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

(2016) Jonathan N. Pruneda et al.   MOLECULAR CELL

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires

(2016) David Burstein et al.   NATURE GENETICS

InterPro in 2017—beyond protein family and domain annotations

(2016) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs

(2015) Florian A. Horenkamp et al.   DEVELOPMENTAL CELL

Lysine11-Linked Polyubiquitination of the AnkB F-Box Effector of Legionella pneumophila

(2015) William M. Bruckert et al.   INFECTION AND IMMUNITY

Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7

(2015) Emiko Uchikawa et al.   NUCLEIC ACIDS RESEARCH

Twenty years of theMEROPSdatabase of proteolytic enzymes, their substrates and inhibitors

(2015) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Metabolism of the vacuolar pathogen Legionella and implications for virulence

(2014) Christian Manske et al.   Frontiers in Cellular and Infection Microbiology

Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires¿ disease

(2014) Laura Gomez-Valero et al.   GENOME BIOLOGY

Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication

(2013) Monica Rolando et al.   Cell Host & Microbe

RNA Polymerase II Transcription Elongation Control

(2013) Jiannan Guo et al.   CHEMICAL REVIEWS

SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription

(2013) Ting Li et al.   EMBO REPORTS

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP

(2013) L. Muniz et al.   NUCLEIC ACIDS RESEARCH

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella

(2012) Tasneem Al-Quadan et al.   TRENDS IN MICROBIOLOGY

Legionella secreted effectors and innate immune responses

(2011) Zhao-Qing Luo   CELLULAR MICROBIOLOGY

Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion

(2011) T. J. O'Connor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

Comparative and Functional Genomics of Legionella Identified Eukaryotic Like Proteins as Key Players in Host?Pathogen Interactions

(2011) Laura Gomez-Valero et al.   Frontiers in Microbiology

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Lipidation by the Host Prenyltransferase Machinery Facilitates Membrane Localization ofLegionella pneumophilaEffector Proteins

(2010) Stanimir S. Ivanov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor

(2010) Ming Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector ofLegionella pneumophila

(2010) Christopher T.D. Price et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The perplexing functions and surprising origins ofLegionella pneumophilatype IV secretion effectors

(2009) Irina S. Franco et al.   CELLULAR MICROBIOLOGY

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

Molecular Characterization of the Dot/Icm-Translocated AnkH and AnkJ Eukaryotic-Like Effectors of Legionella pneumophila

(2009) F. Habyarimana et al.   INFECTION AND IMMUNITY

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

(2009) Y. Xue et al.   NUCLEIC ACIDS RESEARCH

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

(2009) M. Barboric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional diversity of ankyrin repeats in microbial proteins

(2009) Souhaila Al-Khodor et al.   TRENDS IN MICROBIOLOGY

Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa

(2009) Christopher T. Price et al.   PLoS Pathogens

Host cell processes that influence the intracellular survival of Legionella pneumophila

(2008) Sunny Shin et al.   CELLULAR MICROBIOLOGY

Role for the Ankyrin eukaryotic-like genes of Legionella pneumophila in parasitism of protozoan hosts and human macrophages

(2008) Fabien Habyarimana et al.   ENVIRONMENTAL MICROBIOLOGY

Lgt: a Family of Cytotoxic Glucosyltransferases Produced by Legionella pneumophila

(2008) Y. Belyi et al.   JOURNAL OF BACTERIOLOGY

A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

(2008) Nanhai He et al.   MOLECULAR CELL

A Dot/Icm-translocated ankyrin protein ofLegionella pneumophilais required for intracellular proliferation within human macrophages and protozoa

(2008) Souhaila Al-Khodor et al.   MOLECULAR MICROBIOLOGY

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions

(2008) Tomoko Kubori et al.   MOLECULAR MICROBIOLOGY

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH

Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors

(2008) X. Pan et al.   SCIENCE