Article
Biochemistry & Molecular Biology
Bao-Ying Luo, Jie Zhou, Dan Guo, Qian Yang, Qin Tian, Dun-Peng Cai, Rui-Mei Zhou, Zhen-Zhen Xu, Hui-Jun Wang, Shi-You Chen, Wei-Bing Xie
Summary: This study demonstrates the association between methamphetamine and thoracic aortic aneurysm/dissection (TAAD), as well as the underlying mechanism. Methamphetamine exposure leads to elastin breakage and loss and degeneration of medial cells through the regulation of C/EBP beta expression. The findings may have important implications for the clinical diagnosis and treatment of TAAD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Editorial Material
Endocrinology & Metabolism
Ke Zhu, Jochen Reiser
Summary: Diabetic kidney disease is affected by both genetic and environmental factors. A recent study has identified risk variants in the XOR promoter that increase its own activity in response to high blood sugar levels, which play a causative role in the development and progression of diabetic kidney disease.
Article
Food Science & Technology
Xiaohong Lin, Weiye Xu, Liu Liu, Shiyi Ou, Xichun Peng
Summary: The metabolites of flaxseed polysaccharide fermented by fecal bacteria were found to inhibit glucose intake and lipid accumulation, which might be a weight-loss mechanism of flaxseed polysaccharide through regulating intestinal microbiota.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Masayuki Yamamoto, Yasuna Nagasawa, Ko Fujimori
Summary: Glycyrrhizic acid (GA) inhibits adipogenesis in mouse 3T3-L1 cells by modulating the glycerite pathway and suppressing the expression of adipogenic and lipogenic genes, thus showing potential as an agent for treating obesity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Chen Li, Zhourui Wu, Liqiang Zhou, Jingliang Shao, Xiao Hu, Wei Xu, Yilong Ren, Xingfei Zhu, Weihong Ge, Kunshan Zhang, Jiping Liu, Runzhi Huang, Jing Yu, Dandan Luo, Xuejiao Yang, Wenmin Zhu, Rongrong Zhu, Changhong Zheng, Yi Eve Sun, Liming Cheng
Summary: This study provides a comprehensive mapping of cellular and molecular pathological changes along the temporal axis after SCI, revealing prolonged alterations in different cell types. The findings may contribute to the development of novel therapeutic strategies for SCI.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Cell Biology
Han Yan, Qi Li, Mengying Li, Xiuqun Zou, Ningning Bai, Zichao Yu, Jie Zhang, Dan Zhang, Qun Zhang, Jiamin Wang, Hao Jia, Yingjie Wu, Zhaoyuan Hou
Summary: The study shows that depletion of Ajuba in 3T3-L1 cells reduces the expression of PPARγ and C/EBPα, impairing adipocyte differentiation, while overexpression increases their expression and promotes differentiation. Restoring C/EBPα or PPARγ expression in Ajuba-deficient cells improves impaired lipid accumulation. Ajuba interacts with C/EBPβ and recruits CBP to enhance binding to the promoter regions of PPARγ and C/EBPα, leading to increased gene expression.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Integrative & Complementary Medicine
Gyorgyi Horvath, Adrienn Horvath, Greta Reichert, Andrea Boszormenyi, Katalin Sipos, Edina Pandur
Summary: Essential oils from thyme are effective in preventing neuroinflammation and related neurodegeneration, with different chemotypes and main compounds showing varying degrees of anti-inflammatory effects. Pretreatment with essential oils can significantly reduce the secretion of inflammatory cytokines, while main compounds exhibit strong inhibitory effects on specific cell signalling components related to proinflammatory cytokine expression.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Oncology
Mei Qin, Fei Han, Jian Wu, Feng-Xia Gao, Yuan Li, De-Xin Yan, Xue-Mei He, Yang Long, Xiao-Ping Tang, De-Lian Ren, Yan Gao, Tian-Yang Dai
Summary: This study reveals that KDM6B promotes ESCC progression by enhancing C/EBP beta transcription through its H3K27 demethylase activity. Additionally, the chemical inhibitor GSK-J4 can effectively inhibit ESCC cell proliferation and metastasis.
Article
Oncology
Daria Frank, Ramkumar Moorthy, John C. Widen, Cyrus Khandanpour, Daniel A. Harki, Karl-Heinz Klempnauer, Luca Abdel Ghani, Maria V. Yusenko, Wolfgang Doerner
Summary: C/EBP β is a transcription factor that cooperates with MYB to maintain proliferation and differentiation block of AML cells. A synthetic analog of helenalin inhibits C/EBP β by covalently binding to cysteine residues in the transactivation domain, leading to enhanced differentiation, cell death, and reduced self-renewal potential of AML cells. Gene expression profiling confirms the relevance of C/EBP β as a therapeutic target. However, further development is needed to improve the effectiveness of the synthetic analog as a C/EBP β inhibitor.
Article
Biochemistry & Molecular Biology
Ana Sierra-Magro, Fernando Bartolome, David Lozano-Munoz, Jesus Alarcon-Gil, Elena Gine, Marina Sanz-SanCristobal, Sandra Alonso-Gil, Marta Cortes-Canteli, Eva Carro, Ana Perez-Castillo, Jose A. Morales-Garcia
Summary: Parkinson's disease (PD) is a neurodegenerative disorder caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The transcription factor CCAAT/Enhancer Binding Protein beta (C/EBP beta) may be a good therapeutic target for PD treatment due to its altered levels in neurodegenerative diseases. A list of PD-related genes regulated by C/EBP beta was generated, including mitochondrial transcription factor A (TFAM). The absence of C/EBP beta may lead to the accumulation of non-functional mitochondria due to impaired autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yijun Lin, Meiqin Huang, Shuo Wang, Xue You, Lingling Zhang, Yan Chen
Summary: PAQR11 plays a critical role in monocyte-to-macrophage differentiation by promoting cell survival, and its function is associated with autoimmune diseases in vivo.
Article
Cell Biology
Xiaoyang Wang, Weili Cheng, Xiaopan Chen, Yanan Gong, Guangjie Wang, Xiaoxue Zhang, Yuanyuan Qi
Summary: This study investigated the role and mechanism of CCAAT/enhancer-binding protein beta (CEBPB) in lupus nephritis (LN). The results showed that CEBPB inhibition improved renal structure impairments and renal function damage associated with LN by suppressing NLRP3 inflammasome activation and cell pyroptosis.
MEDIATORS OF INFLAMMATION
(2022)
Article
Chemistry, Multidisciplinary
Yihua Bei, Yujiao Zhu, Meng Wei, Mingming Yin, Lin Li, Chen Chen, Zhenzhen Huang, Xuchun Liang, Juan Gao, Jianhua Yao, Petra H. van der Kraak, Aryan Vink, Zhiyong Lei, Yuxiang Dai, Huihua Chen, Yueyang Liang, Joost P. G. Sluijter, Junjie Xiao
Summary: It is observed that HIPK1 is increased during pathological cardiac hypertrophy. Both genetic ablation and gene therapy targeting HIPK1 are protective against pathological hypertrophy and heart failure in vivo. HIPK1 inhibition prevents cardiomyocyte hypertrophy and transcription of pathological response genes.
Article
Multidisciplinary Sciences
Yuta Takanezawa, Shogo Tanabe, Daiki Kato, Rie Ozeki, Masayo Komoda, Tatsunori Suzuki, Hiroko Baba, Rieko Muramatsu
Summary: Deficiency of Chd8 or Tsc2 in microglia leads to reduced expression of insulin-like growth factor-1 (Igf1) and inhibited phagocytosis activity. Tsc2 deficiency also inhibits microglia-mediated oligodendrocyte development, while Chd8 or Tsc2 deficiency prevents the differentiation of oligodendrocyte precursor cells to oligodendrocytes. This suggests that ASD-related gene expression in microglia plays a role in oligodendrocyte differentiation, potentially contributing to white matter pathology in ASD.
SCIENTIFIC REPORTS
(2021)
Article
Fisheries
Dongdong Li, Ming Guo, Weikang Liang, Chunhua Jin, Chenghua Li
Summary: This study revealed the functional role of CHOP in sea cucumbers and the mechanism by which it regulates apoptosis. It was found that in sea cucumbers, CHOP mediates apoptosis induced by V. splendidus through the activation of the p38-MAPK pathway rather than the JNK/ERK-MAPK pathway.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Neurosciences
Xiang Xu, Enping Huang, Yunchun Tai, Xu Zhao, Xuebing Chen, Chuanxiang Chen, Rui Chen, Chao Liu, Zhoumeng Lin, Huijun Wang, Wei-Bing Xie
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Editorial Material
Cardiac & Cardiovascular Systems
Xuebing Chen, Qi Miao, Yangeng Yu, Fu Zhang, Leping Sun, Yunle Meng, Huijun Wang, Dongri Li
ANNALS OF THORACIC SURGERY
(2019)
Article
Biochemistry & Molecular Biology
Xuebing Chen, Feng Qiu, Xu Zhao, Jiancong Lu, Xiaohui Tan, Jingtao Xu, Chuanxiang Chen, Fu Zhang, Chao Liu, Dongfang Qiao, Huijun Wang
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Xu Zhao, Jiancong Lu, Xuebing Chen, Zhengxiang Gao, Cui Zhang, Chuanxiang Chen, Dongfang Qiao, Huijun Wang
Summary: The study identified the molecular mechanisms of METH-induced neuronal programmed necrosis, showing that RIP3 plays a crucial role in the process and could be a potential therapeutic target for METH-induced neurotoxicity.
Article
Clinical Neurology
Xue-Bing Chen, Dong Qu, Qing Zhang, Xia Yue, Dong-Fang Qiao
Summary: This case study reports the death of a 30-year-old man due to acute pulmonary edema during rt-pa thrombolytic therapy, emphasizing the importance of closely monitoring vital sign changes and being aware of the risk of pulmonary edema during thrombolysis.
Article
Cell Biology
Jingshen Zhuang, Xuebing Chen, Guixing Cai, Dizheng Wu, Chen Tu, Siyuan Zhu, Yusheng Huang, Ping Xu, Zhaoming Zhong
Summary: Accumulation of AOPPs is associated with enhanced osteoclastogenesis and deterioration of bone microstructure in aged mice. In vitro experiments showed that AOPPs directly induce osteoclastogenesis by activating various signaling pathways, leading bone marrow monocytes to differentiate into mature osteoclasts.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Xuebing Chen, Jingshen Zhuang, Qianling Chen, Luyao Xu, Xia Yue, Dongfang Qiao
Summary: This study investigated the toxic effects of PVC-MPs on mice, and found that PVC-MPs can cause intestinal injury and alter gut microbiome composition and metabolome profiles. The research is of great importance in assessing the health risks of PVC-MPs to humans.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemical Research Methods
Xuebing Chen, Shengjie Nie, Liping Hu, Yating Fang, Wei Cui, Hui Xu, Congying Zhao, Bo-Feng Zhu
Summary: The aim of this study was to investigate the genetic characteristics and forensic application values of 57 autosomal InDel loci in the Chinese YM group. The results showed that these InDels were suitable for forensic individual identification and paternity testing. The genetic similarities between the YM group and East Asian populations were higher than that between the YM group and other geographical populations.
Review
Medicine, Legal
Qianling Chen, Xuebing Chen, Luyao Xu, Rui Zhang, Zhigang Li, Xia Yue, Dongfang Qiao
Summary: Traumatic brain injury (TBI) has high morbidity and poor prognosis, and traumatic axonal injury (TAI) is a common pathological change in the primary injury of TBI. However, the postmortem diagnosis of TAI-caused death is still challenging, with a lack of recognized diagnostic indicators. Therefore, studying the postmortem diagnosis of TAI is of great significance in forensic pathology.
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2022)
Article
Environmental Sciences
Xuebing Chen, Jingshen Zhuang, Qianling Chen, Luyao Xu, Xia Yue, Dongfang Qiao
Summary: Exposure to polyvinyl chloride microplastics (PVC-MPs) causes liver injury and dysbiosis of gut microbiota in mice. Furthermore, PVC-MPs exposure leads to decreased levels of serum and hepatic triglyceride and total bile acid. RNA sequencing analysis of liver tissue identified differentially expressed genes associated with multiple pathways.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Cell Biology
Luyao Xu, Lingyue Li, Qianling Chen, Yuebing Huang, Xuebing Chen, Dongfang Qiao
Summary: Methamphetamine (METH), a highly toxic amphetamine-type stimulant, has led to global addiction and various public health and safety issues. Recent studies have shown that non-coding RNA (ncRNA) plays a crucial role in METH addiction through different mechanisms. This article focuses on long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which are involved in neurotoxic effects of METH abuse such as cognitive impairment, behavioral abnormalities, and psychiatric disorders. Differential expression (DE) ncRNAs also suggest specific responses and sensitivity to METH neurotoxicity in different brain regions and cells. The findings provide new insights and strategies for the prevention and treatment of METH abuse.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hui Xu, Shengjie Nie, Liping Hu, Xuebing Chen, Ming Zhao, Xi Yuan, Yifeng Lin, Bofeng Zhu
Summary: The Chinese Yunnan Hani ethnic group was investigated using 57 autosomal InDel genetic markers and compared to 30 global reference populations. The results showed that this novel InDel multiplex amplification system could be used as a powerful tool for personal identification and paternity testing in the Chinese Yunnan Hani group.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
