Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor

Cerebrospinal fluid HIV RNA in persons living with HIV

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Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice

(2018) Lei Qian et al.   MOLECULAR NEUROBIOLOGY

The viral protein gp120 decreases the acetylation of neuronal tubulin: potential mechanism of neurotoxicity

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Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research

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Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice

(2017) Mona Buhusi et al.   Frontiers in Aging Neuroscience

Expression of gp120 in mice evokes anxiety behavior: Co-occurrence with increased dendritic spines and brain-derived neurotrophic factor in the amygdala

(2016) Alessia Bachis et al.   BRAIN BEHAVIOR AND IMMUNITY

Identification of a binding site of the human immunodeficiency virus envelope protein gp120 to neuronal-specific tubulin

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HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

The neurotrophin receptor p75 mediates gp120-induced loss of synaptic spines in aging mice

(2016) Alessia Bachis et al.   NEUROBIOLOGY OF AGING

The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons

(2016) Valeria Avdoshina et al.   NEUROTOXICITY RESEARCH

BDNF pro-peptide regulates dendritic spines via caspase-3

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The Potential of the CNS as a Reservoir for HIV-1 Infection: Implications for HIV Eradication

(2015) Alessandro F. Fois et al.   Current HIV/AIDS Reports

A Role for the p75 Neurotrophin Receptor in Axonal Degeneration and Apoptosis Induced by Oxidative Stress

(2014) Bradley R. Kraemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine

(2013) Brook L. Henry et al.   BEHAVIOURAL PHARMACOLOGY

Synaptodendritic injury with HIV-Tat protein: What is the therapeutic target?

(2013) Avindra Nath et al.   EXPERIMENTAL NEUROLOGY

Distinct Roles for Somatically and Dendritically Synthesized Brain-Derived Neurotrophic Factor in Morphogenesis of Dendritic Spines

(2013) L. L. Orefice et al.   JOURNAL OF NEUROSCIENCE

Impaired neurogenesis and neurite outgrowth in an HIV-gp120 transgenic model is reversed by exercise via BDNF production and Cdk5 regulation

(2013) Myoung-Hwa Lee et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model

(2013) Juliet K. Knowles et al.   NEUROBIOLOGY OF AGING

Dendritic spines: from structure to in vivo function

(2012) Nathalie L Rochefort et al.   EMBO REPORTS

Human Immunodeficiency Virus Type 1 Alters Brain-Derived Neurotrophic Factor Processing in Neurons

(2012) A. Bachis et al.   JOURNAL OF NEUROSCIENCE

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity

(2012) Carlos F. Ibáñez et al.   TRENDS IN NEUROSCIENCES

Divergent Roles ofp75NTRand Trk Receptors in BDNF's Effects on Dendritic Spine Density and Morphology

(2012) Christopher A. Chapleau et al.   NEURAL PLASTICITY

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

(2011) K. Deinhardt et al.   Science Signaling

Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics

(2010) Marco B Rust et al.   EMBO JOURNAL

Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy

(2010) I Everall et al.   JOURNAL OF NEUROVIROLOGY

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

(2010) Katya J Park et al.   NATURE NEUROSCIENCE

Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease

(2010) Myoung-Hwa Lee et al.   NEUROBIOLOGY OF DISEASE

Structural dynamics of dendritic spines in memory and cognition

(2010) Haruo Kasai et al.   TRENDS IN NEUROSCIENCES

Synapse development and plasticity: roles of ephrin/Eph receptor signaling

(2009) Kwok-On Lai et al.   CURRENT OPINION IN NEUROBIOLOGY

Molecular Pathology of Neuro-AIDS (CNS-HIV)

(2009) Leslie Crews et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

M- and T-tropic HIVs Promote Apoptosis in Rat Neurons

(2008) Alessia Bachis et al.   Journal of Neuroimmune Pharmacology

Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration

(2008) Karun K Singh et al.   NATURE NEUROSCIENCE

Contribution of Hippocampal and Extra-Hippocampal NR2B-Containing NMDA Receptors to Performance on Spatial Learning Tasks

(2008) Jakob von Engelhardt et al.   NEURON

p75NTR Mediates Ephrin-A Reverse Signaling Required for Axon Repulsion and Mapping

(2008) Yoo-Shick Lim et al.   NEURON

Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats

(2007) David Scott Tait et al.   BEHAVIOURAL BRAIN RESEARCH

Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning

(2007) Sarvin Ghods-Sharifi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY