Article
Oncology
Yangkun Wang, Yingying Li, Bin Wang, Dongmei Ran, Chaoya Zhu, Ping Li, Bo Jiang, Sunan Wang
Summary: This study investigated the early onset, development, and histological features of gastric signet-ring cell carcinoma (SRCC). The results showed that gastric mucosa infection, especially by Helicobacter pylori, can cause massive cell proliferation and transformation in specific areas of the stomach. SRCC grows infiltratively and can differentiate into various types of adenocarcinoma with signet-ring cell differentiation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Ju Seok Kim, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Summary: There was no significant difference in pathologic and endoscopic size in SRC-type EGC. Therefore, ESD may be considered as a therapeutic option if the size of the tumor is less than 20 mm and atrophy is not present in the surrounding mucosa.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Oncology
Chi Zhang, Ran Liu, Wei-Han Zhang, Xin-Zu Chen, Kai Liu, Kun Yang, Xiao-Long Chen, Lin-Yong Zhao, Zhi-Xin Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: The study found that patients with signet ring cell gastric cancer are typically younger and more commonly female compared to those with non-signet ring cell gastric cancer. For early stage signet ring cell gastric cancer patients, they have a lower lymph nodes metastasis rate and comparable prognosis with non-signet ring cell cancers; however, in advanced tumor stage, signet ring cell gastric cancer has a significantly worse prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Luigina Graziosi, Elisabetta Marino, Nicola Natalizi, Annibale Donini
Summary: This study investigates the clinical pathological characteristics and survival prognostic significance of signet ring cell components in patients affected by gastric cancer. The incidence of signet ring cell carcinoma is increasing over time. The prognosis of signet ring cell carcinoma is better in early gastric cancer, but recurrence occurs more frequently in these patients. Factors such as preoperative serum albumin level, surgical resection, lymphadenectomy level, and pathological stage are independent factors affecting overall survival. Radical surgical procedures and adequate lymphadenectomy should be advocated to improve patient survival.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nang Lae Lae Phoo, Pornngarm Dejkriengkraikul, Patompong Khaw-On, Supachai Yodkeeree
Summary: The study identified AKR1C1 and 1C3 as key regulators of cisplatin resistance in signet ring cell gastric carcinoma (SRCGC) through modulation of redox-dependent autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Chunlei Fan, Wei Guo, Guoqiang Su, Bo Chen, Haojun Chen
Summary: The study compared Ga-68-FAPI and F-18-FDG PET/CT in a patient with GSRCC and found that Ga-68-FAPI PET/CT demonstrated superior tumor-to-background contrast and detected more metastatic lesions than F-18-FDG PET/CT. This case highlights the better performance of Ga-68-FAPI PET/CT in identifying both primary and metastatic lesions in GSRCC compared to F-18-FDG PET/CT.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Surgery
Jia-Bin Wang, Man-Qiang Lin, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chao-Hui Zheng, Chang-Ming Huang
Summary: This study evaluated the prognostic impact of body mass index (BMI) on signet ring cell gastric carcinoma (SRC) patients. The results showed that as BMI decreases, SRC has a worse prognostic impact. Different BMI levels can lead to differing prognosis of SRC compared with tubular adenocarcinoma.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Cheng-liang Chen, Di-xin Xue, Ha-ha Chen, Mei-zhen Liang, Dao-zhe Lin, Ming Yu, Ji-xian Chen, Wei-li Wu
Summary: Nomograms were developed to predict overall survival (OS) and cancer-specific survival (CSS) in patients with signet-ring cell carcinoma (SRCC) of the stomach. The nomograms included various clinical variables and showed good predictive ability in calibration plots, ROC curves, and DCA. The new model was found to be more useful than the TNM staging system.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Oncology
Shuai Zhao, Ling Lv, Kai Zheng, Yu Tian, Jian-Chun Zheng, Cheng-Gang Jiang
Summary: The prognosis of SRC is better at early stage compared to other types of gastric cancer, while it is relatively poorer at advanced stage.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qing Wang, Xiaolong Chen, Jianqing Zhang, Yuting Luo, Kehua Jiang
Summary: Urachal signet ring cell carcinoma is a rare and aggressive tumor. We reported a new case and conducted a literature review to enhance our understanding of this disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yu Yang, Yoshimasa Akashi, Osamu Shimomura, Hiroaki Tateno, Sayoko Saito, Keiko Hiemori, Yoshihiro Miyazaki, Tomoaki Furuta, Daichi Kitaguchi, Yukihito Kuroda, Louphrasitthiphol Pakavarin, Tatsuya Oda
Summary: Specific glycan profiles in SRC cells were reported, showing reduced alpha 2-6-linked sialic acids. Additionally, a targeted therapy using the rBC2LCN lectin might be applicable as an alternative treatment option for patients with SRC.
Article
Oncology
Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu, Jieer Ying
Summary: A total of 11,363 gastric cancer patients were enrolled, with SRC patients more likely to occur in female and young patients. Significant factors for prognosis included age, tumor site, tumor size, T classification, N classification, TNM stage, and primary site surgery, as identified through univariate and multivariate analyses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cong Li, Yun Qin, Wei-Han Zhang, Hanyu Jiang, Bin Song, Mustafa R. Bashir, Heng Xu, Ting Duan, Mengjie Fang, Lianzhen Zhong, Lingwei Meng, Di Dong, Zhenhua Hu, Jie Tian, Jian-Kun Hu
Summary: The study developed a noninvasive AI model based on preoperative CT scans to diagnose and predict prognoses of SRCC in gastric cancer patients. The AI model showed good performance in diagnosing SRCC, stratifying patient prognosis, and predicting chemotherapy responses. Patients identified as high-risk by the AI model may benefit significantly from adjuvant chemotherapy.
Article
Oncology
Qinping Guo, Yinquan Wang, Jie An, Siben Wang, Xiushan Dong, Haoliang Zhao
Summary: The study aimed to develop a predictive model for overall survival (OS) and cancer-specific survival (CSS) in GSRC patients. Multivariate Cox regression analyses were used to construct nomograms for both OS and CSS, showing better predictive ability compared to TNM and SEER staging. Calibration curves demonstrated good consistency between predicted and actual 3-year and 5-year OS and CSS.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Yimin Shen, Yuanyuan Li, Zhou Wang, Wei Xu, Wenjie Wang, Xiao Chen
Summary: This study suggests that FCS is a prognostic and effective biomarker for patients with surgically resectable GSRC. The developed FCS-based predictive model can assist clinicians in determining treatment strategies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Ya-kai Huang, Wei-ming Kang, Zhi-qiang Ma, Yu-qin Liu, Li Zhou, Jian-chun Yu
Review
Oncology
Qing-Bin Meng, Jing-Jing Peng, Zi-Wei Qu, Xiao-Min Zhu, Zhang Wen, Wei-Ming Kang
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2019)
Review
Oncology
Xian-Ze Wang, Zi-Yang Zeng, Xin Ye, Juan Sun, Zi-Mu Zhang, Wei-Ming Kang
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2020)
Article
Medicine, Research & Experimental
Changzhen Zhu, Yuqin Liu, Weiming Kang, Zimu Zhang, Ziyang Zeng, Dong Liu
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Nutrition & Dietetics
Jing-Yong Xu, Xian-Na Zhang, Zhu-Ming Jiang, Bin Jie, Yang Wang, Wei Li, Jens Kondrup, Marie T. Nolan, Martha Andrews, Wei-Ming Kang, Xin Ye, Kang Yu, Ming-Wei Zhu, Qian Lu
Article
Oncology
Xiao Liu, Zhigang Xue, Jianchun Yu, Zijian Li, Zhiqiang Ma, Weiming Kang, Xin Ye, Lin Jiang
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Medicine, Research & Experimental
Juan Sun, Weiming Kang, Ziyang Zeng, Zimu Zhang, Xianze Wang
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Nutrition & Dietetics
Yingjing Zhang, Zijian Li, Lin Jiang, Zhigang Xue, Zhiqiang Ma, Weiming Kang, Xin Ye, Yuqin Liu, Zhengyu Jin, Jianchun Yu
Summary: This study found that patients with gastric cancer undergoing radical gastrectomy have worse survival outcomes when experiencing significant loss of adipose tissue during neoadjuvant treatment. The loss of visceral adipose tissue and subcutaneous adipose tissue during treatment was associated with poorer overall survival and disease-free survival, while changes in skeletal muscle mass and body weight did not affect survival.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2021)
Article
Nutrition & Dietetics
Yingjing Zhang, Zijian Li, Lin Jiang, Zhigang Xue, Zhiqiang Ma, Weiming Kang, Xin Ye, Yuqin Liu, Zhengyu Jin, Jianchun Yu
Summary: This study aimed to investigate the association between body composition and clinical outcomes in individuals with gastric cancer. Results suggest that sarcopenia, high visceral adipose tissue, and low subcutaneous adipose tissue may affect the incidence of postoperative complications and long-term survival in these patients.
Article
Oncology
Lin Jiang, Zhiqiang Ma, Xin Ye, Weiming Kang, Jianchun Yu
Summary: In a retrospective study on gastric cancer patients, factors such as age <60, histological type of poor differentiation or signet-ring cell carcinoma, and weight loss during neoadjuvant chemotherapy were identified as independent risk factors for the effect of neoadjuvant chemotherapy. Patients with weight loss >2.95% during neoadjuvant chemotherapy may have a worse chemotherapy effect. Providing timely nutritional support such as oral nutritional supplements to maintain patients' body weight is crucial for improving the effect of neoadjuvant chemotherapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Xuehan Gao, Yuanjing Gao, Xin Ye, Weiming Kang
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Juan Sun, Xianze Wang, Zimu Zhang, Ziyang Zeng, Siwen Ouyang, Weiming Kang
Summary: Research on predicting the sensitivity of NACT for gastric cancer spans multiple aspects including biomarkers, inflammatory indicators, and imaging assessments. While numerous studies have been conducted on biomarkers, a unified conclusion has not yet been reached. Inflammatory indicators have been shown to be associated with the survival and prognosis of patients undergoing NACT, and imaging assessments such as CT, MRI, and PET may offer unique advantages in early screening for NACT-sensitive patients through careful integration and optimization.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ziyang Zeng, Kang Li, Xianze Wang, Siwen Ouyang, Zimu Zhang, Zhen Liu, Juan Sun, Xin Ye, Weiming Kang, Jianchun Yu
Summary: An increase in iodine intake has been associated with the rising incidence of papillary thyroid cancer (PTC). However, lower iodine intake was found to be a protective factor for central lymph node metastasis (CLNM) in PTC, particularly in cases with tumors smaller than 1 cm. These results suggest that iodine may play a dual role in PTC development, both as an initiator and a promoter of tumorigenesis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Ziyang Zeng, Kang Li, Weiming Kang, Jianchun Yu, Xianze Wang, Zimu Zhang, Juan Sun, Siwen Ouyang
Article
Multidisciplinary Sciences
Haifeng Sun, Li Zhang, Pianhong Zhang, Jianchun Yu, Weiming Kang, Shuli Guo, Wei Chen, Xuqi Li, Shufeng Wang, Lianzhen Chen, Jianxiong Wu, Zibin Tian, Xianghua Wu, Xiaosun Liu, Yinghua Liu, Xinying Wang
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
