Article
Oncology
Xin Wang, Dong-Bing Zhao, Lin Yang, Yihebali Chi, Hong Zhao, Li-Ming Jiang, Jun Jiang, Yuan Tang, Ning Li, Wen-Yang Liu, Li-Zhou Dou, Shuang-Mei Zou, Li-Yan Xue, Jian-Song Ren, Yan-Tao Tian, Xu Che, Chun-Guang Guo, Xiao-Feng Bai, Yue-Min Sun, Shu-Lian Wang, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Ye-Xiong Li, Jing Jin
Summary: This study compared the efficacy and safety of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy for locally advanced gastric cancer. The results showed that neoadjuvant chemoradiotherapy resulted in better tumor regression but did not improve the R0 resection rate. There was no significant difference in postoperative complications between the two groups.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sicong Hou, Ziyin Pan, Xin Hao, Qinglei Hang, Yanbing Ding
Summary: Neoadjuvant therapy, including chemotherapy and chemoradiotherapy, has been shown to improve overall survival in patients with locally advanced resectable esophageal cancer. However, controversies persist regarding the optimal combination of neoadjuvant treatments and the need for further investigations to optimize protocols and surveillance strategies.
Article
Biochemistry & Molecular Biology
Jun Yin, Jingnan Yuan, Yunjin Li, Yong Fang, Ruoxi Wang, Heng Jiao, Han Tang, Shaoyuan Zhang, Siyun Lin, Feng Su, Jianmin Gu, Tian Jiang, Dong Lin, Zhiliang Huang, Chaoxiang Du, Kui Wu, Lijie Tan, Qing Zhou
Summary: This study reported a phase 1b trial of neoadjuvant PD-L1 blockade with adebrelimab in resectable esophageal squamous cell carcinoma (ESCC). The results showed that the use of adebrelimab was safe and feasible, with some patients achieving a complete pathologic response. Responsive patients had an improved immune microenvironment at baseline.
Review
Oncology
Wenwei Yang, Yaru Niu, Yongkun Sun
Summary: Locally advanced esophageal cancer has a poor prognosis, and neoadjuvant therapy has become a hot topic in improving its survival benefit. Various studies have confirmed the efficacy of neoadjuvant therapy followed by surgery, including chemoradiotherapy and chemotherapy. Newer treatments like targeted therapy and immunotherapy are being evaluated for their effectiveness in combination with neoadjuvant therapy. Surrogate endpoints are being developed to speed up the approval of neoadjuvant drugs. This review discusses the research progress and primary endpoints in neoadjuvant therapy for locally advanced esophageal cancer.
Article
Oncology
Selena S. Li, Samuel J. Klempner, Christina L. Costantino, Aparna Parikh, Jeffrey W. Clark, Jennifer Y. Wo, Theodore S. Hong, John T. Mullen
Summary: The choice of treatment sequencing significantly impacts completion rates of multimodal therapy in locally advanced gastric cancer patients. Total neoadjuvant therapy followed by surgery (TNT + S) had higher completion rates and comparable survival compared to perioperative therapy. Further prospective investigations into TNT are needed.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Joana Vidal, David Casadevall, Beatriz Bellosillo, Carles Pericay, Rocio Garcia-Carbonero, Ferran Losa, Laia Layos, Vicente Alonso, Jaume Capdevila, Javier Gallego, Ruth Vera, Antonieta Salud, Marta Martin-Richard, Miguel Nogue, Elena Cillan, Joan Maurel, Iris Faull, Victoria Raymond, Carlos Fernandez-Martos, Clara Montagut
Summary: The study showed that in patients with LARC undergoing TNT, the detection of presurgery ctDNA identified individuals at high risk of systemic recurrence, with shorter disease-free survival and overall survival. This sets the foundation for future clinical trials using liquid biopsy to personalize treatment post TNT.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Huaqin Lin, Lei Wang, Xiaohong Zhong, Xueqing Zhang, Lingdong Shao, Junxin Wu
Summary: This meta-analysis comparing neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACRT) for locally advanced rectal cancer (LARC) found that NAC was superior to NACRT in terms of sphincter preservation rate, but noninferior in terms of other outcomes. Further validation is needed for these conclusions.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Runkai Huang, Zhenbin Qiu, Chunwen Zheng, Ruijie Zeng, Wanxian Chen, Simeng Wang, Enmin Li, Yiwei Xu
Summary: Esophageal carcinoma is a highly aggressive malignant disease. Neoadjuvant chemotherapy and chemoradiotherapy are considered the standard treatments for locally advanced esophageal cancers, but there are uncertainties regarding the optimal regimen and evaluation methods.
FRONTIERS IN ONCOLOGY
(2022)
Review
Surgery
Qingbin Wu, Jiahao Zhou, Jun Huang, Xiangbing Deng, Changtao Li, Wenjian Meng, Yazhou He, Ziqiang Wang
Summary: This meta-analysis aimed to compare the differences in pathological complete response rate and survival outcomes among patients who received different treatments for rectal cancer. It showed that total neoadjuvant therapy with short-course radiotherapy or long-course chemoradiotherapy improved the pathological complete response rate compared to long-course chemoradiotherapy alone. Total neoadjuvant therapy with long-course chemoradiotherapy and consolidation chemotherapy was associated with better disease-free survival. Both total neoadjuvant therapy with short-course radiotherapy and total neoadjuvant therapy with long-course chemoradiotherapy had similar outcomes in terms of pathological complete response rate and survival.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
E. L. Vos, R. A. Carr, M. Hsu, M. Nakauchi, T. Nobel, A. Russo, A. Barbetta, K. S. Tan, L. Tang, D. Ilson, G. Y. Ku, A. J. Wu, Y. Y. Janjigian, S. S. Yoon, M. S. Bains, D. R. Jones, D. Coit, D. Molena, V. E. Strong
Summary: In patients undergoing surgical resection for locally advanced adenocarcinoma of the gastro-oesophageal junction, there was no significant difference in overall survival and disease-free survival between those who had neoadjuvant chemoradiation compared with chemotherapy.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Xuan Zhao, Peiyi Han, Luyang Zhang, Junjun Ma, Feng Dong, Lu Zang, Zirui He, Minhua Zheng
Summary: This study compared the efficacy of total neoadjuvant therapy (TNT) with prolonged neoadjuvant chemotherapy (pNCT) without radiation in patients with locally advanced rectal cancer (LARC). The results showed that TNT had better pathological complete response and objective regression rates compared to pNCT. In patients with mid-to-upper rectal cancer, TNT and pNCT had similar recurrence-free survival and overall survival rates. However, radiation was still necessary for low rectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Emre Ozoran, Ibrahim Halil Ozata, Derya Salim Uymaz, Nail Omarov, Emre Bozkurt, Tutku Tufekci, Salih Nafiz Karahan, Buelent Gurbuz, Fatih Selcukbiricik, Yasemin Bolukbasi, Orhun cig Taskin, Bengi Gurses, Ahmet Rencuzogullari, Dursun Bugra, Emre Balik
Summary: This study compared the efficacy of total neoadjuvant therapy (TNT) and standard neoadjuvant chemoradiotherapy (SNCRT) in locally advanced rectal cancer patients. The study results showed that the TNT group had significantly higher rates of pathological and sustained clinical complete response compared to the SNCRT group. However, these outcomes did not translate into a survival advantage.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Multidisciplinary Sciences
Fuqiang Wang, Boon Fei Tan, Sharon Shuxian Poh, Tian Rui Siow, Faye Lynette Wei Tching Lim, Connie Siew Poh Yip, Michael Lian Chek Wang, Wenlong Nei, Hong Qi Tan
Summary: A feasibility study investigated the role of CT-based radiomics in predicting treatment response and survival rates in rectal cancer patients. By constructing NAR and survival models, radiomics features were found to be more accurate in predicting outcomes. CTV radiomics features were especially important in NAR prediction.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Wei Wang, Ying Peng, Xingyu Feng, Yan Zhao, Sharvesh Raj Seeruttun, Jun Zhang, Zixuan Cheng, Yong Li, Zaiyi Liu, Zhiwei Zhou
Summary: Neoadjuvant therapies have been shown to improve outcomes in locally advanced gastric cancer patients. This study used pretreatment CT images and radiomics to identify relevant features that can predict treatment response, showing promising results in both training and validation cohorts.
Article
Gastroenterology & Hepatology
Gong Chen, Ying Jin, Wen-Long Guan, Rong-Xin Zhang, Wei-Wei Xiao, Pei-Qiang Cai, Min Liu, Jun-Zhong Lin, Fu-Long Wang, Cong Li, Ting-Ting Quan, Shao-Yan Xi, Hui-Zhong Zhang, Zhi-Zhong Pan, Feng Wang, Rui-Hua Xu
Summary: This study found that sintilimab, a PD-1 monoclonal antibody, is effective and well-tolerated in patients with mismatch-repair deficient locally advanced rectal cancer, and it may potentially spare some patients from radical surgery. Further treatment and follow-up observation are needed.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Oncology
Xiao Liu, Zhigang Xue, Jianchun Yu, Zijian Li, Zhiqiang Ma, Weiming Kang, Xin Ye, Lin Jiang
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Medicine, Research & Experimental
Juan Sun, Weiming Kang, Ziyang Zeng, Zimu Zhang, Xianze Wang
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Nutrition & Dietetics
Yingjing Zhang, Zijian Li, Lin Jiang, Zhigang Xue, Zhiqiang Ma, Weiming Kang, Xin Ye, Yuqin Liu, Zhengyu Jin, Jianchun Yu
Summary: This study found that patients with gastric cancer undergoing radical gastrectomy have worse survival outcomes when experiencing significant loss of adipose tissue during neoadjuvant treatment. The loss of visceral adipose tissue and subcutaneous adipose tissue during treatment was associated with poorer overall survival and disease-free survival, while changes in skeletal muscle mass and body weight did not affect survival.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2021)
Article
Nutrition & Dietetics
Yingjing Zhang, Zijian Li, Lin Jiang, Zhigang Xue, Zhiqiang Ma, Weiming Kang, Xin Ye, Yuqin Liu, Zhengyu Jin, Jianchun Yu
Summary: This study aimed to investigate the association between body composition and clinical outcomes in individuals with gastric cancer. Results suggest that sarcopenia, high visceral adipose tissue, and low subcutaneous adipose tissue may affect the incidence of postoperative complications and long-term survival in these patients.
Article
Oncology
Xianze Wang, Hao Chen, Rui Jiang, Xiafei Hong, Junya Peng, Wenyan Chen, Jialin Jiang, Jie Li, Dan Huang, Hongmei Dai, Wenze Wang, Junliang Lu, Yupei Zhao, Wenming Wu
Summary: The study confirmed the pro-tumor effects of IL-17 and Notch pathways in PanIN/PDAC progression and identified a positive correlation between IL-17 and Notch. Furthermore, co-inhibition of IL-17 and Notch pathways was shown to enhance therapeutic efficacy by restricting tumor growth.
Article
Oncology
Lin Jiang, Zhiqiang Ma, Xin Ye, Weiming Kang, Jianchun Yu
Summary: In a retrospective study on gastric cancer patients, factors such as age <60, histological type of poor differentiation or signet-ring cell carcinoma, and weight loss during neoadjuvant chemotherapy were identified as independent risk factors for the effect of neoadjuvant chemotherapy. Patients with weight loss >2.95% during neoadjuvant chemotherapy may have a worse chemotherapy effect. Providing timely nutritional support such as oral nutritional supplements to maintain patients' body weight is crucial for improving the effect of neoadjuvant chemotherapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Xuehan Gao, Yuanjing Gao, Xin Ye, Weiming Kang
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Juan Sun, Xianze Wang, Zimu Zhang, Ziyang Zeng, Siwen Ouyang, Weiming Kang
Summary: Research on predicting the sensitivity of NACT for gastric cancer spans multiple aspects including biomarkers, inflammatory indicators, and imaging assessments. While numerous studies have been conducted on biomarkers, a unified conclusion has not yet been reached. Inflammatory indicators have been shown to be associated with the survival and prognosis of patients undergoing NACT, and imaging assessments such as CT, MRI, and PET may offer unique advantages in early screening for NACT-sensitive patients through careful integration and optimization.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ziyang Zeng, Kang Li, Xianze Wang, Siwen Ouyang, Zimu Zhang, Zhen Liu, Juan Sun, Xin Ye, Weiming Kang, Jianchun Yu
Summary: An increase in iodine intake has been associated with the rising incidence of papillary thyroid cancer (PTC). However, lower iodine intake was found to be a protective factor for central lymph node metastasis (CLNM) in PTC, particularly in cases with tumors smaller than 1 cm. These results suggest that iodine may play a dual role in PTC development, both as an initiator and a promoter of tumorigenesis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Xianze Wang, Jialin Jiang, Wenmin Guan, Wei Yu, Tao Xu, Mei Li, Jia Zhang
Summary: Clustered vertebral compression fractures (C-VCFs) are rare adverse consequences of severe osteoporosis, and glucocorticoid treatment, recent fracture history, and lower trabecular bone score (TBS) are unique risk factors for C-VCFs.
ENDOCRINE PRACTICE
(2022)
Article
Surgery
Ziyang Zeng, Kang Li, Weiming Kang, Jianchun Yu, Xianze Wang, Zimu Zhang, Juan Sun, Siwen Ouyang
