Circadian clock-controlled drug metabolism and transport

The nuclear receptor Rev-erbα participates in circadian regulation of Ugt2b enzymes in mice

(2019) Tianpeng Zhang et al.   BIOCHEMICAL PHARMACOLOGY

The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice

(2019) Yongbin Tong et al.   BIOCHEMICAL PHARMACOLOGY

Circadian Cyp3a11 metabolism contributes to chronotoxicity of hypaconitine in mice

(2019) Yanke Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling

(2019) Alper Okyar et al.   Scientific Reports

Role of the CLOCK protein in liver detoxification

(2019) Mengjing Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression

(2019) Cui Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Cyp3a11 metabolism-based chronotoxicity of brucine in mice

(2019) Ziyue Zhou et al.   TOXICOLOGY LETTERS

Diurnal expression of ABC and SLC transporters in jejunum is modulated by adrenalectomy

(2019) Karla Vagnerová et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice

(2018) Mengjing Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor Gamma

(2018) Jiangming Deng et al.   DRUG METABOLISM AND DISPOSITION

The Clock Protein Bmal1 Regulates Circadian Expression and Activity of Sulfotransferase 1a1 in Mice

(2018) Lianxia Guo et al.   DRUG METABOLISM AND DISPOSITION

Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite

(2017) Laura Kervezee et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Circadian Clock Is Involved in Regulation of Hepatobiliary Transport Mediated by Multidrug Resistance-Associated Protein 2

(2017) Ju-Hee Oh et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

(2015) Jay Tibbitts et al.   mAbs

Identification of Circadian Determinants of Cancer Chronotherapy through In Vitro Chronopharmacology and Mathematical Modeling

(2015) S. Dulong et al.   MOLECULAR CANCER THERAPEUTICS

Circadian Clock Proteins and Immunity

(2014) Anne M. Curtis et al.   IMMUNITY

Bile Acid-regulated Peroxisome Proliferator-activated Receptor-α (PPARα) Activity Underlies Circadian Expression of Intestinal Peptide Absorption Transporter PepT1/Slc15a1

(2014) Ayako Okamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hepatic Circadian Clock Modulates Xenobiotic Metabolism in Mice

(2014) Jason P. DeBruyne et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Chronopharmacology: New Insights and Therapeutic Implications

(2013) Robert Dallmann et al.   Annual Review of Pharmacology and Toxicology

PHASE II DRUG METABOLIZING ENZYMES

(2012) Petra Jancova et al.   BIOMEDICAL PAPERS-OLOMOUC

Modulation of the ATPase and Transport Activities of Broad-Acting Multidrug Resistance Factor ABCC10 (MRP7)

(2012) E. V. Malofeeva et al.   CANCER RESEARCH

Circadian Regulation of the Hepatic Endobiotic and Xenobitoic Detoxification Pathways: The Time Matters

(2012) Ursula Prosenc Zmrzljak et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Reactions and enzymes in the metabolism of drugs and other xenobiotics

(2012) Bernard Testa et al.   DRUG DISCOVERY TODAY

Clocks, Metabolism, and the Epigenome

(2012) Dan Feng et al.   MOLECULAR CELL

Circadian clocks and drug delivery systems: impact and opportunities in chronotherapeutics

(2011) Francis Lévi et al.   Expert Opinion on Drug Delivery

Circadian clock and cardiovascular disease

(2011) Norihiko Takeda et al.   Journal of Cardiology

PharmGKB summary

(2011) Torben S. Mikkelsen et al.   Pharmacogenetics and Genomics

Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum

(2011) Alper Okyar et al.   PLoS One

Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner

(2011) Naomi Tanimura et al.   TOXICOLOGY

Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species

(2011) Ling Ye et al.   TOXICOLOGY LETTERS

Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action☆

(2010) Siddharth Sukumaran et al.   ADVANCED DRUG DELIVERY REVIEWS

Chronotherapy and the molecular clock: Clinical implications in oncology☆

(2010) Pasquale F. Innominato et al.   ADVANCED DRUG DELIVERY REVIEWS

The Role of Clock Genes in Pharmacology

(2010) Georgios K. Paschos et al.   Annual Review of Pharmacology and Toxicology

Molecular Modeling of Cytochrome P450 and Drug Metabolism

(2010) Jing-Fang Wang et al.   CURRENT DRUG METABOLISM

The role of circadian timing system on drug metabolism and detoxification

(2010) Frédéric Gachon et al.   Expert Opinion on Drug Metabolism & Toxicology

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data

(2009) Tycho Heimbach et al.   AAPS Journal

LIVER CIRCADIAN CLOCK, A PHARMACOLOGIC TARGET OF CYCLIN-DEPENDENT KINASE INHIBITOR SELICICLIB

(2009) Ida Iurisci et al.   CHRONOBIOLOGY INTERNATIONAL

Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers

(2009) T. Izukawa et al.   DRUG METABOLISM AND DISPOSITION

Circadian clock genes and sleep homeostasis

(2009) P. Franken et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Circadian Dysregulation Disrupts Bile Acid Homeostasis

(2009) Ke Ma et al.   PLoS One

Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1)

(2008) Hirofumi Saito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Circadian Clock-Controlled Intestinal Expression of the Multidrug-Resistance Gene mdr1a in Mice

(2008) Yuichi Murakami et al.   GASTROENTEROLOGY

The molecular mechanism regulating 24-hour rhythm ofCYP2E1expression in the mouse liver

(2008) Naoya Matsunaga et al.   HEPATOLOGY

Phase III, Double-Blind, Randomized Study Comparing Lapatinib Plus Paclitaxel With Placebo Plus Paclitaxel As First-Line Treatment for Metastatic Breast Cancer

(2008) Angelo Di Leo et al.   JOURNAL OF CLINICAL ONCOLOGY

Diurnal Rhythmicity in the Transcription of Jejunal Drug Transporters

(2008) Adam T. Stearns et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Circadian Variations in Rat Liver Gene Expression: Relationships to Drug Actions

(2008) R. R. Almon et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

(2008) Andrew C. Liu et al.   PLoS Genetics