Review
Environmental Sciences
Tahereh Farkhondeh, Michael Aschner, Mahmood Sadeghi, Omid Mehrpour, Kobra Naseri, Alireza Amirabadizadeh, Babak Roshanravan, Hamed Aramjoo, Saeed Samarghandian
Summary: The study established an association between DZN exposure and hyperglycemia in rodents and fish, which is dose- and gender-dependent.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Environmental Sciences
Hamed Aramjoo, Tahereh Farkhondeh, Micheal Aschner, Kobra Naseri, Omid Mehrpour, Parisa Sadighara, Babak Roshanravan, Saeed Samarghandian
Summary: The systematic and meta-analysis study revealed that DZN significantly increased total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels in rodents and fish species, while significantly decreasing high-density lipoprotein cholesterol levels. These effects were found to be dose-dependent.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Lilia M. Bliznashka, Aditi Roy, David Christiani, Antonia Calafat, Maria M. Ospina, Nancy Diao, Maitreyi Mazumdar, Lindsay Jaacks
Summary: This study examined the association between pesticide exposure during pregnancy and child development. The findings showed a negative relationship between pesticide exposure and motor development in rural Bangladesh, while the association with cognitive development was minimal. Additionally, a systematic review and meta-analysis of studies conducted in low- and middle-income countries concluded that pregnancy pesticide exposure was not significantly associated with cognitive, language, or motor development. The study highlights the importance of interventions to reduce prenatal pesticide exposure in low-income and middle-income countries for the protection of child development.
Review
Neurosciences
Joel Arvin Rodrigues, Rekha K. Narasimhamurthy, Manjunath B. Joshi, Herman Sunil Dsouza, Kamalesh Dattaram Mumbrekar
Summary: Exposure to pesticides leads to alterations in metabolites that are linked to the pathogenesis of neurodegenerative diseases.
NEUROTOXICITY RESEARCH
(2022)
Article
Environmental Sciences
Mahdiyar Saraji, Khalil Talebi, Mahdi Balali-Mood, Sohrab Imani
Summary: This study investigated the effects of diazinon and chlorpyrifos on urinary metabolites in agricultural workers exposed to pesticides. The results showed that both farm workers and sprayer operators had detectable levels of the metabolites, while the control group did not. The IMPy levels of sprayer operators were significantly higher than the TCPy levels. Additionally, there was a significant relationship between metabolite levels and the use of personal protective equipment and working time.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2022)
Article
Nanoscience & Nanotechnology
Yunxia Yang, Qian Liu, Yisong Zhao, Jianmin Chen, Bing Chen, Yanling Yan, Faming Gao
Summary: This study explored CuPt alloy nanotubes with an open end, which have a larger electrochemical active surface area and more active sites for enzyme immobilization, thus improving the efficiency and sensitivity of the biosensor.
Article
Multidisciplinary Sciences
Iffat Imran, Asma Ansari, Saima Saleem, Abid Azhar, Sitwat Zehra
Summary: This study evaluated the toxic potential of different pesticides at a cellular and genetic level in Sanghar, Sindh, Pakistan. The results showed that locally consumed pesticides had cytotoxic effects on cells and exposed individuals showed significant differences in genotypic and allelic frequencies compared to controls.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Li Zhang, Jiaxin Ma, Peipei Liu, Anxiang Qi, Haiyan Jin, Renming Jia, Zhenming Zheng, Cheng Yan, Minghong Cai
Summary: With the prohibition of conventional organochlorine pesticides, the use of current-use pesticides such as organic amine pesticides and organophosphate pesticides in agriculture and mariculture activities has become a global concern. A study in the Beibu Gulf, a subtropical agricultural and maricultural zone, found that pesticides were widely present in seawater and sediment, with the most abundant categories being organic amine pesticides and organophosphate pesticides. The spatial distribution of pesticides showed a decrease from coastal areas to the sea, indicating the impact of anthropogenic activities on pesticides pollution.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Chemistry, Physical
Nayana Bhat, Bodee Nutho, Alisa Vangnai, Kaito Takahashi, Thanyada Rungrotmongkol
Summary: This study investigated the binding interactions of three organophosphate pesticides with GpdQ enzyme using computational approaches. The results showed that the pesticides binding could stabilize the enzyme structure in the active conformation, allowing the substrate to be catalyzed into less harmful products. The in silico analysis presented here could be informative for enhancing enzyme stability and activity in the future.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Engineering, Environmental
Xiali Zhong, Yuejin Yu, Can Wang, Qicheng Zhu, Jingwei Wu, Weijian Ke, Di Ji, Congying Niu, Xifei Yang, Yanhong Wei
Summary: TPHP exposure affects learning and memory behaviors by disturbing synaptogenesis and neurotransmission, as evidenced by reduced protein levels of TUBB3 and SYP in synapses, downregulated gene expression of neurotransmitter receptors, and inhibited synaptic exocytosis in the hippocampus.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Environmental Sciences
Efthimios Dardiotis, Panagiotis Skouras, Orfeas-Petros Varvarelis, Athina-Maria Aloizou, Antonio F. Hernandez, Ioannis Liampas, Dimitrios Rikos, Metaxia Dastamani, Kirill S. Golokhvast, Dimitrios P. Bogdanos, Aristidis Tsatsakis, Vasileios Siokas, Panayiotis D. Mitsias, Georgios M. Hadjigeorgiou
Summary: Pesticides can cause tremors and other diseases related to the nervous system. More research and preventive measures are needed to protect exposed populations from potential disabilities and social drawbacks.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Steven B. Symington, Abigail C. Toltin, Edwin Murenzi, David Lansky, John M. Clark
Summary: Microtransplantation of neurolemma tissue fragments from mammalian brain into Xenopus laevis oocytes is a useful method for studying ion channels and receptors associated with the central nervous system. Adult neurolemma displayed higher expression levels of voltage-sensitive sodium channels (VSSCs) compared with juvenile neurolemma, and juvenile neurolemma showed higher sensitivity to pyrethroids. However, the age-related differences are not likely to be toxicologically relevant due to the low exposure concentrations in human brains.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Environmental Sciences
Hongxiu Liu, Anna Maria Campana, Yuyan Wang, Kurunthachalam Kannan, Mengling Liu, Hongkai Zhu, Shilpi Mehta-Lee, Sara G. Brubaker, Linda G. Kahn, Leonardo Trasande, Akhgar Ghassabian
Summary: The study found that pregnant women in NYC had lower levels of OP pesticide metabolites than pregnant populations in Europe, Asia, and other regions in the U.S. Lower pre-pregnancy body mass index, being Asian, employed, and single were associated with higher DAP metabolite concentrations, while fruit and grain intakes were associated with higher Sigma DM, Sigma DE, and Sigma DAP levels.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Majid Zeinali, Azam Shafaei, Houshang Rafatpanah, Arman Mosavat, Naser Tayebi-Meybodi, Hossein Hosseinzadeh, Seyed Abdolrahim Rezaee
Summary: This study investigated the sub-acute toxicity of diazinon (DZN) and the protective activities of chrysin (CH) on the immune system of mice. The results showed that DZN can damage the liver and suppress immune cell populations and functions, while CH can overcome the toxic effects of DZN and enhance immune cell and antibody production.
SCIENTIFIC REPORTS
(2022)
Article
Toxicology
Wanyu He, Jiaqi Ding, Ning Gao, Lingyan Zhu, Lin Zhu, Jianfeng Feng
Summary: This study expands the understanding of the toxicity of organophosphate esters (OPEs) and systematically identifies the mechanism of OPEs toxicity under the framework of adverse outcome pathway (AOP). The results show that the toxicity mechanism of OPEs on aquatic organisms and mammals differ, primarily due to their different biological metabolic systems.
ARCHIVES OF TOXICOLOGY
(2023)