Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease

Role of airway glucose in bacterial infections in patients with chronic obstructive pulmonary disease

(2018) Patrick Mallia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exacerbation induces a microbiota shift in sputa of COPD patients

(2018) Eric Jubinville et al.   PLoS One

Effects of fluticasone propionate and budesonide on the expression of immune defense genes in bronchial epithelial cells

(2018) M. van den Berge et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

(2018) Aran Singanayagam et al.   Nature Communications

The lung tissue microbiota of mild and moderate chronic obstructive pulmonary disease

(2018) Alexa A. Pragman et al.   Microbiome

Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease

(2017) Louise J.P Persson et al.   EUROPEAN RESPIRATORY JOURNAL

Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD

(2017) Marco Contoli et al.   EUROPEAN RESPIRATORY JOURNAL

Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis

(2017) Kohei Hasegawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke

(2017) Gimano D. Amatngalim et al.   Journal of Innate Immunity

Airway Mucin Concentration as a Marker of Chronic Bronchitis

(2017) Mehmet Kesimer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhaled Corticosteroids and Respiratory Infections in Children With Asthma: A Meta-analysis

(2017) Cristine Cazeiro et al.   PEDIATRICS

The impact of persistent bacterial bronchitis on the pulmonary microbiome of children

(2017) Leah Cuthbertson et al.   PLoS One

Lung tissue proteomics identifies elevated transglutaminase 2 levels in stable chronic obstructive pulmonary disease

(2016) Steffen Ohlmeier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD

(2016) Joseph Footitt et al.   CHEST

Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line

(2016) Nikhil Nitin Kulkarni et al.   IMMUNOBIOLOGY

Critical Role of Antimicrobial Peptide Cathelicidin for ControllingHelicobacter pyloriSurvival and Infection

(2016) Lin Zhang et al.   JOURNAL OF IMMUNOLOGY

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

(2016) Silke M. Currie et al.   JOURNAL OF IMMUNOLOGY

Predictors of Severe Sepsis among Patients Hospitalized for Community-Acquired Pneumonia

(2016) Beatriz Montull et al.   PLoS One

A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD

(2015) Aran Singanayagam et al.   CLINICAL SCIENCE

Cathelicidin Antimicrobial Peptide: A Novel Regulator of Islet Function, Islet Regeneration, and Selected Gut Bacteria

(2015) Lynley D. Pound et al.   DIABETES

Using Corticosteroids to Reshape the Gut Microbiome

(2015) Edmond Y. Huang et al.   INFLAMMATORY BOWEL DISEASES

Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers

(2015) Hasitha Shilpa Anantaraju et al.   MOLECULAR DIVERSITY

Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium

(2014) G. J. Zijlstra et al.   EUROPEAN RESPIRATORY JOURNAL

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

(2014) Paula E. Beaumont et al.   PLoS One

Clinical Features, Etiology and Outcomes of Community-Acquired Pneumonia in Patients with Chronic Obstructive Pulmonary Disease

(2014) Joan Gómez-Junyent et al.   PLoS One

Extrafine beclomethasone/formoterol in severe COPD patients with history of exacerbations

(2014) J.A. Wedzicha et al.   RESPIRATORY MEDICINE

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

(2013) Alison Morris et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Budesonide suppresses pulmonary antibacterial host defense by down-regulating cathelicidin-related antimicrobial peptide in allergic inflammation mice and in lung epithelial cells

(2013) Peng Wang et al.   BMC IMMUNOLOGY

Invasive pneumococcal disease in patients with an underlying pulmonary Disorder

(2013) M. Inghammar et al.   CLINICAL MICROBIOLOGY AND INFECTION

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

The Expression and Activity of Cathepsins D, H and K in Asthmatic Airways

(2013) Alen Faiz et al.   PLoS One

Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella Pneumoniae in mice

(2013) Craig M Patterson et al.   RESPIRATORY RESEARCH

Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials

(2013) Mark T Dransfield et al.   Lancet Respiratory Medicine

Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease

(2012) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease

(2012) Marc A. Sze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Muramyl dipeptide mediated activation of human bronchial epithelial cells interacting with basophils: a novel mechanism of airway inflammation

(2012) H. N. Qiu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cathelicidin-Related Antimicrobial Peptide Is Required for Effective Lung Mucosal Immunity in Gram-Negative Bacterial Pneumonia

(2012) M. A. Kovach et al.   JOURNAL OF IMMUNOLOGY

Beta Defensin-2 Is Reduced in Central but Not in Distal Airways of Smoker COPD Patients

(2012) Elisabetta Pace et al.   PLoS One

The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease

(2012) John Steer et al.   THORAX

Behavioral and Structural Differences in Migrating Peripheral Neutrophils from Patients with Chronic Obstructive Pulmonary Disease

(2011) Elizabeth Sapey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Severity and outcomes of hospitalised community-acquired pneumonia in COPD patients

(2011) A. Liapikou et al.   EUROPEAN RESPIRATORY JOURNAL

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

Toll-like receptor expression in smokers with and without COPD

(2011) Ida von Scheele et al.   RESPIRATORY MEDICINE

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Risks of Pneumonia in Patients with Asthma Taking Inhaled Corticosteroids

(2010) Paul M. O'Byrne et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reported Pneumonia in Patients With COPD

(2010) Peter M.A. Calverley et al.   CHEST

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Urokinase-type plasminogen activator system and human cationic antimicrobial protein 18 in serum and induced sputum of patients with chronic obstructive pulmonary disease

(2010) Yuanyuan JIANG et al.   RESPIROLOGY

Assigning strains to bacterial species via the internet

(2009) Cynthia J Bishop et al.   BMC BIOLOGY

Defective macrophage phagocytosis of bacteria in COPD

(2009) A. E. Taylor et al.   EUROPEAN RESPIRATORY JOURNAL

LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic Saline

(2009) G. Bergsson et al.   JOURNAL OF IMMUNOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy

(2008) Xin Zheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke

(2008) Esmaeil Mortaz et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

Cigarette smoke decreases MARCO expression in macrophages: Implication in Mycoplasma pneumoniae infection

(2008) Misbah Baqir et al.   RESPIRATORY MEDICINE

The Prevention of Chronic Obstructive Pulmonary Disease Exacerbations by Salmeterol/Fluticasone Propionate or Tiotropium Bromide

(2007) Jadwiga A. Wedzicha et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE