Review
Health Care Sciences & Services
Nachiket Gudi, Prashanthi Kamath, Trishnika Chakraborty, Anil G. Jacob, Shradha S. Parsekar, Suptendra Nath Sarbadhikari, Oommen John
Summary: Although there is recognition of the scientific value of data sharing from clinical trials, there are various limitations and challenges in implementing data sharing practices. This review highlights the need for a pragmatic data-sharing mechanism to improve research and innovations, and calls for the development of flexible yet comprehensive data-sharing policies. It also emphasizes the importance of institutional mechanisms and policy interventions in facilitating data sharing, particularly in low- and middle-income countries.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Yu Zhang, Jie Wang, Jiakai Chen, Weizhong Liu
Summary: This study explores the impact of China's environmental regulation policy on the business performance of manufacturing enterprises. The empirical results show a positive correlation between the policy and business performance, with an inverted U-shaped relationship. The promotion effect is mainly seen in non-state-owned, western, and technological-intensive enterprises, and is reflected through the innovation compensation mechanism. This study provides reference for the Chinese government to adjust environmental regulation policies and achieve sustainable development.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Immunology
Joanna Balcerek, Brian R. Shy, Amy L. Putnam, Lisa M. Masiello, Angela Lares, Florinna Dekovic, Luis Acevedo, Michael R. Lee, Vinh Nguyen, Weihong Liu, Sreenivasan Paruthiyil, Jingying Xu, Ashley S. Leinbach, Jeffrey A. Bluestone, Qizhi Tang, Jonathan H. Esensten
Summary: The manufacturing outcomes of PolyTreg products were consistent across different clinical trials and production dates, with cell fold expansion primarily correlated to the initial cell number. Parameters such as manufacturing date, patient sex, and age did not significantly affect Treg cell expansion during product manufacturing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Economics
Zhiming Hu, Jie Xiong, Jie Yan, Zhe Yuan, Shubho Chakraborty
Summary: The study reveals that the Chinese government emphasizes both horizontal and vertical coordination in the formulation and implementation of policies for industrial upgrading. The same set of policy instruments are applied by governments at all levels, with environmental instruments being the most frequently used, followed by supply- and demand-side instruments. The key policy topics include innovation, industrial transformation, industrial agglomeration, demonstration projects, and service-oriented manufacturing.
Review
Pharmacology & Pharmacy
Dipak Kumar Gupta, Mohd Humair Ali, Asad Ali, Pooja Jain, Md. Khalid Anwer, Zeenat Iqbal, Mohd. Aamir Mirza
Summary: The widespread consumerization of 3D printing innovation has revolutionized its access in various industries, particularly in healthcare. Despite its promising applications in pharmaceutical and clinical fields, 3D printing still faces regulatory challenges that need to be carefully addressed for its successful implementation.
JOURNAL OF DRUG TARGETING
(2022)
Review
Medicine, General & Internal
Abed El-Hakim El-Kadiry, Moutih Rafei, Riam Shammaa
Summary: Cell therapy practices have a long history dating back to the 19th century, and continue to evolve with a focus on investigational and investment aspects. There are different types of cell therapies, including both stem cell and non-stem cell-based therapies, with varied immunophenotypic profiles and mechanisms of action. The benefits of cell therapies in regenerative medicine, immune diseases, and cancer have been reported, leading to a shift towards combined therapy approaches and highlighting the attractiveness of multicellular therapies over unicellular ones.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Sergio G. Garcia, Noelia Sandoval-Hellin, Marcella Franquesa
Summary: Bregs are gaining attention in the context of kidney injury, as their restoration and balance could serve as potential therapeutic tools. Efforts are being made to identify specific markers defining Bregs as a unique cell subset, while exploring induction mechanisms for further research and applications in kidney disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Henrique Rodrigues Scherer Coelho, Silvia Cordeiro das Neves, Jovino Nogueira da Silva Menezes, Andreia Conceicao Milan Brochado Antoniolli-Silva, Rodrigo Juliano Oliveira
Summary: This research evaluated the effects of cell therapy with adipose tissue-derived stem cells on the treatment of detrusor underactivity in men. The results showed that cell therapy improved voiding function, increased maximum flow and urinated volume, and reduced residual volume. The International Consultation on Incontinence Questionnaire scores also decreased, indicating an improvement in quality of life. Adipose tissue-derived stem cell therapy is a safe and effective new option for the treatment of detrusor underactivity.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Kristy Ou, Dania Hamo, Anne Schulze, Andy Roemhild, Daniel Kaiser, Gilles Gasparoni, Abdulrahman Salhab, Ghazaleh Zarrinrad, Leila Amini, Stephan Schlickeiser, Mathias Streitz, Joern Walter, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Julia K. Polansky
Summary: The study found that DNA methylation changes occur during the manufacturing process of Treg products, which may impact the functionality of Treg products by possibly shifting to an effector Treg phenotype with enhanced functional activity or by risking destabilization of Treg identity and impaired TCR activation. Additionally, epigenetic profiling is valuable for evaluating T cell product manufacturing pipelines.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Leila Amini, Jaspal Kaeda, Enrico Fritsche, Andy Roemhild, Daniel Kaiser, Petra Reinke
Summary: Rejection of solid organ transplant and graft versus host disease (GvHD) remain challenging in transplantation management. Adoptive T cell (ATC) therapy has emerged as a promising approach in regenerative medicine, with various cell types actively investigated as potential therapeutic agents. Preclinical models have shown efficacy, and early clinical trials have confirmed safety and tolerability of cellular therapeutics. Specifically, CD4(+)CD25+FOXP3+ regulatory T cells (Tregs) have been approved and used to minimize immune response and reduce immunosuppression in transplant recipients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K. James, Niels Olsen Saraiva Camara, S. M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Zheng Liu, Chaohong Liu
Summary: In this article, the authors summarize the regulatory relationship between B cells and T cells, mainly focusing on T follicular regulatory cells and regulatory B cells. They introduce a new subset of regulatory T cells induced by B cells, and discuss the role of B cells in ensuring the survival of regulatory T cells. This review provides an updated overview of immunoregulatory networks and identifies potential targets for therapeutic interventions against cancer, autoimmune diseases, and allograft rejection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
David F. Stroncek, Robert P. T. Somerville, Steven L. Highfill
Summary: The use of cellular therapies for various diseases is rapidly increasing, leading to the development of reagents and automated instruments for production. There is a growing interest in decentralized manufacturing for clinical trials, but this requires harmonization of processes and quality control between multiple sites.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Bo Wang, Junping Yu, Rui Wu
Summary: China has committed to achieving carbon neutrality by 2060. However, this task is considerably difficult. By analyzing policies and laws issued in China from 2019 to the present, this study assesses how the Chinese government plans to achieve its carbon neutrality targets. The results show that China's carbon neutrality policies and laws emphasize comprehensive coverage, rational use of executive power, and development of low-carbon technologies. However, existing policies and laws remain unclear, with low levels of legislation and insufficient public participation.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Energy & Fuels
Argjenta Veseli, Simon Moser, Klaus Kubeczko, Verena Madner, Anna Wang, Klaus Wolfsgruber
Summary: The legal framework designed for an established energy regime presents barriers for innovative solutions in energy transition. Testing solutions in regulatory sandboxes, despite the lack of explicit authorization in Austrian energy law, can be a constructive tool for innovation policy. This paper investigates the practical need for regulatory sandboxes in Austria and proposes necessary changes for energy law eligibility, considering European law.
Article
Green & Sustainable Science & Technology
Muhammad Asyraf Azni, Rasyikah Md Khalid
Summary: Researchers reviewed the legal framework for HFC in the United States, Germany, and South Korea, finding that these countries have established proper legal frameworks for HFC.
Review
Biophysics
K. K. Ballen, F. Verter, J. Kurtzberg
BONE MARROW TRANSPLANTATION
(2015)
Article
Cell & Tissue Engineering
Pedro S. Couto, Alexey Bersenev, Frances Verter
REGENERATIVE MEDICINE
(2017)
Article
Cell & Tissue Engineering
Pedro S. Couto, Gocha Shatirishvili, Alexey Bersenev, Frances Verter
REGENERATIVE MEDICINE
(2019)
Review
Biotechnology & Applied Microbiology
P. Silva Couto, M. C. Rotondi, A. Bersenev, C. J. Hewitt, A. W. Nienow, F. Verter, Q. A. Rafiq
BIOTECHNOLOGY ADVANCES
(2020)
Article
Meteorology & Atmospheric Sciences
Michael G. Bosilovich, Jon D. Radakovich, Arlindo da Silva, Ricardo Todling, Frances Verter
JOURNAL OF THE METEOROLOGICAL SOCIETY OF JAPAN
(2007)
Article
Astronomy & Astrophysics
F Verter, L Magnani, E Dwek, LJ Rickard
ASTROPHYSICAL JOURNAL
(2000)
