Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus

Impaired long-term immune protection following pneumococcal 13-valent/23-valent polysaccharide vaccine in systemic lupus erythematosus (SLE)

(2018) Karim Sacre et al.   ANNALS OF THE RHEUMATIC DISEASES

Self-Reactive B Cells in the Germinal Center Reaction

(2018) Robert Brink et al.   Annual Review of Immunology

Lupus and vaccinations

(2018) Alexis Mathian et al.   CURRENT OPINION IN RHEUMATOLOGY

Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected repertoires

(2018) Alaitz Aranburu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function

(2018) Peter T. Sage et al.   JOURNAL OF IMMUNOLOGY

Regulation of age-associated B cells by IRF5 in systemic autoimmunity

(2018) Michela Manni et al.   NATURE IMMUNOLOGY

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination

(2018) Deborah L. Burnett et al.   SCIENCE

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

(2018) Shu Wang et al.   Nature Communications

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

(2017) Kira Rubtsova et al.   JOURNAL OF CLINICAL INVESTIGATION

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

(2017) Takeshi Inoue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SHIP-1 Deficiency in AID+B Cells Leads to the Impaired Function of B10 Cells with Spontaneous Autoimmunity

(2017) Yingjia Chen et al.   JOURNAL OF IMMUNOLOGY

Age-Associated B Cells Express a Diverse Repertoire of VHand Vκ Genes with Somatic Hypermutation

(2017) Lisa M. Russell Knode et al.   JOURNAL OF IMMUNOLOGY

Autoimmunity and primary immunodeficiency: two sides of the same coin?

(2017) Reinhold E. Schmidt et al.   Nature Reviews Rheumatology

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Immunogenicity of pneumococcal polysaccharide vaccine in adult systemic lupus erythematosus patients undergoing immunosuppressive treatment

(2016) R P V Rezende et al.   LUPUS

TLR7, IFNγ, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity

(2015) Kira Rubtsova et al.   CELLULAR IMMUNOLOGY

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response

(2015) Clément Jacquemin et al.   IMMUNITY

Age-associated B cells: key mediators of both protective and autoreactive humoral responses

(2015) Martin S. Naradikian et al.   IMMUNOLOGICAL REVIEWS

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

(2015) Anatoly V. Rubtsov et al.   JOURNAL OF IMMUNOLOGY

MiXCR: software for comprehensive adaptive immunity profiling

(2015) Dmitriy A Bolotin et al.   NATURE METHODS

Current issues in chronic graft-versus-host disease

(2014) G. Socie et al.   BLOOD

Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics

(2014) Radhika Goenka et al.   EXPERIMENTAL GERONTOLOGY

Colocalization of Antigen-Specific B and T Cells within Ectopic Lymphoid Tissue following Immunization with Exogenous Antigen

(2014) J. S. Weinstein et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

B Cell Antigen Presentation in the Initiation of Follicular Helper T Cell and Germinal Center Differentiation

(2014) L. G. Barnett et al.   JOURNAL OF IMMUNOLOGY

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

(2014) Leontios Pappas et al.   NATURE

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Signals via the Adaptor MyD88 in B Cells and DCs Make Distinct and Synergistic Contributions to Immune Activation and Tissue Damage in Lupus

(2013) Lino L. Teichmann et al.   IMMUNITY

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

(2013) Dirk Baumjohann et al.   IMMUNITY

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Control of TFH cell numbers: why and how?

(2013) Alvin Pratama et al.   IMMUNOLOGY AND CELL BIOLOGY

Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies

(2013) A Danza et al.   LUPUS

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

(2013) Heping Xu et al.   NATURE

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Aberrant antibody affinity selection in SHIP-deficient B cells

(2012) Wai-Hang Leung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy

(2011) Shannon K. O'Neill et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

(2011) Baidong Hou et al.   IMMUNITY

Genetic Segregation of Inflammatory Lung Disease and Autoimmune Disease Severity in SHIP-1-/- Mice

(2011) M. J. Maxwell et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity during Salmonella typhimurium Infection

(2010) Patricia Neves et al.   IMMUNITY

Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity

(2010) Wenzhong Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction

(2010) J. Rolf et al.   JOURNAL OF IMMUNOLOGY

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Cell Proliferation, Somatic Hypermutation, Class Switch Recombination, and Autoantibody Production in Ectopic Lymphoid Tissue in Murine Lupus

(2009) D. C. Nacionales et al.   JOURNAL OF IMMUNOLOGY

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

(2009) Tomoko Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms

(2008) Baidong Hou et al.   IMMUNITY