Article
Cell Biology
Peter C. Reifsnyder, Kevin Flurkey, Rosalinda Doty, Nigel A. Calcutt, Robert A. Koza, David E. Harrison
Summary: Rapamycin treatment has both positive and negative effects on the progression of type 2 diabetes (T2D) in a mouse model, but combination treatment with metformin can mitigate the negative effects while maintaining the benefits.
Article
Biochemistry & Molecular Biology
Yueqiu Liu, Wen Zheng, Lu Zhang, Liqiang Hu, Xin Liu, Jingqiu Cheng, Guoliang Li, Meng Gong
Summary: This study investigated the hypoglycemic and metabolic effects of Ficus racemosa fruit in diabetic mice and explored its potential mechanisms using a metabolomics approach. The results showed that Ficus racemosa fruit could lower blood glucose levels and improve tissue lesions, primarily by altering amino acid, organic acid, and nucleotide metabolism.
Article
Nanoscience & Nanotechnology
Yanxin Du, Zehang Zhang, Yu Yang, Ting Liu, Tianfeng Chen, Xiaoling Li
Summary: This study demonstrates that selenium nanoparticles combined with metformin can enhance the immunotherapeutic effects of NK cells against osteosarcoma cancer. The nanoparticles are metabolized into selenoproteins, which regulate the redox balance in the tumor microenvironment and reinforce the anticancer effect of NK cells.
Article
Nutrition & Dietetics
Barbara R. Cardoso, Sabine Braat, Ross M. Graham
Summary: The study investigated the association between blood selenium concentration and glucose markers in the representative sample of the US population, finding a positive correlation between selenium and insulin, as well as HOMA-IR. While the associations with insulin and HOMA-IR remained after further adjustments, the correlation with glucose was no longer significant.
FRONTIERS IN NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Jin-Long Tian, Xu Si, Chi Shu, Yue-Hua Wang, Hui Tan, Zhi-Huan Zang, Wei-Jia Zhang, Xu Xie, Yi Chen, Bin Li
Summary: The simultaneous use of metformin and anthocyanin-rich foods has a synergistic effect in reducing blood glucose levels and improving insulin resistance in diabetic patients. The combination treatment also regulates signaling pathways and alters gut microbial composition, leading to enhanced therapeutic efficacy.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Raphaelle Corremans, Benjamin A. Vervaet, Geert Dams, Patrick C. D'Haese, Anja Verhulst
Summary: Diabetic Kidney Disease (DKD) is a common complication for diabetic patients and a leading cause of chronic kidney disease. The study compared the renoprotective effects of various antidiabetic drugs in a rat model of DKD and found that metformin and canagliflozin both showed protective effects against DKD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kelly Yichen Li, Claudia Ha Ting Tam, Hongbo Liu, Samantha Day, Cadmon King Poo Lim, Wing Yee So, Chuiguo Huang, Guozhi Jiang, Mai Shi, Heung Man Lee, Hui-yao Lan, Cheuk-Chun L. Szeto, Robert L. G. Hanson, Robert G. Nelson, Katalin Susztak, Juliana C. N. Y. Chan, Kevin Y. Yip, Ronald C. W. Ma
Summary: In this study, the authors identified CpG sites associated with kidney function and subsequent decline, highlighting the potential of methylation markers in risk stratification of kidney disease in individuals with type 2 diabetes. The use of both single-site and multisite analysis proved to have functional significance in the kidney.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Roisin Hambly, Niamh Kearney, Rosalind Hughes, Jean M. Fletcher, Brian Kirby
Summary: Hidradenitis suppurativa (HS) is an inflammatory disease that affects both the skin and the whole body, causing significant impact on mental health and quality of life. Metformin is commonly used for HS treatment and has shown effectiveness for certain patients, although its mechanism of action is not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Samuel Asamoah Sakyi, Edwin Ferguson Laing, Richard Mantey, Alexander Kwarteng, Eddie-Williams Owiredu, Richard Ephraim Dadzie, Benjamin Amoani, Stephen Opoku, Bright Oppong Afranie, Daniel Boakye
Summary: Prolonged use of metformin in diabetic patients is associated with vitamin B12 deficiency and peripheral neuropathy. This study found a high prevalence of vitamin B12 deficiency in metformin-treated T2DM patients, with correlations to immunological markers and cardiometabolic risk factors.
Article
Medicine, General & Internal
Zhaohua Zhu, Jing-Yang Huang, Guangfeng Ruan, Peihua Cao, Shibo Chen, Yan Zhang, Weiyu Han, Tianyu Chen, Xiaoyan Cai, Jia Liu, Yujin Tang, Na Yu, Qian Wang, David J. Hunter, James Cheng-Chung Wei, Changhai Ding
Summary: This study found a significant association between the use of metformin and a reduced risk of joint replacement in patients with type 2 diabetes mellitus.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2022)
Article
Cell Biology
Ehsan Ranaei Pirmardan, Yuanlin Zhang, Aliaa Barakat, Marzieh Naseri, Christoph Russmann, Ali Hafezi-Moghadam
Summary: This study reveals the cellular and molecular causes of cataractogenesis, indicating the migration of immune cells and epithelial-mesenchymal transformation as underlying causes.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Catarina Chaves, Filipe Cunha, Mariana Martinho, Susana Garrido, Margarida Silva-Vieira, Catarina Estevinho, Anabela Melo, Odete Figueiredo, Ana Morgado, Maria Ceu Almeida, Margarida Almeida
Summary: The study found that women with gestational diabetes mellitus (GDM) treated with insulin plus metformin had similar obstetric and neonatal outcomes, as well as gestational weight gain and insulin dose, compared to those treated with insulin alone.
ACTA DIABETOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Fan Gu, Liang Tao, Runling Chen, Jiao Zhang, Xingzhong Wu, Min Yang, Jun Sheng, Yang Tian
Summary: This study demonstrated that Moringa oleifera leaf polysaccharides (MOLP) have antioxidant activity and α-glucosidase inhibitory activity, and can alleviate high glucose-induced insulin resistance. The results provide new ideas for the in-depth study of MOLP in basic research and industrial application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Sevgican Demir, Peter P. Nawroth, Stephan Herzig, Bilges Ekim Ustunel
Summary: Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance and high blood sugar levels, with complications affecting various organs. Effective therapies are lacking, and further research on novel treatment targets is needed to pave the way for potential prevention and treatment of this disease.
Article
Multidisciplinary Sciences
Jestin Chellian, Kit-Kay Mak, Dinesh Kumar Chellappan, Purushotham Krishnappa, Mallikarjuna Rao Pichika
Summary: The combination of quercetin and metformin has a stronger antidiabetic effect than either drug alone and can reverse endothelial dysfunction in diabetic rats.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Mahmoud Balbaa, Razan Hammoud, Hoda Yusef
LETTERS IN DRUG DESIGN & DISCOVERY
(2016)
Editorial Material
Cell Biology
Salah A. Sheweita, Mahmoud Balbaa, Samy L. Habib
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2016)
Article
Cell Biology
Mahmoud Balbaa, Marwa El-Zeftawy, Doaa Ghareeb, Nabil Taha, Abdel Wahab Mandour
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2016)
Article
Environmental Sciences
S. A. Sheweita, Y. Y. El Banna, M. Balbaa, I. A. Abdullah, H. E. Hassan
ENVIRONMENTAL TOXICOLOGY
(2017)
Article
Toxicology
Mahmoud Balbaa, Heba Omran, Nihad Abdel-Monem, Mohamed El-Sayed, Nabila Abdelmeguid
Article
Environmental Sciences
Y. R. Shahin, N. M. Elguindy, A. Abdel Bary, M. Balbaa
ENVIRONMENTAL TOXICOLOGY
(2018)
Article
Multidisciplinary Sciences
Mahmoud Balbaa, Shaymaa A. Abdulmalek, Sofia Khalil
Article
Chemistry, Medicinal
Mahmoud Balbaa, Doaa Awad, Ahmad Abd Elaal, Shimaa Mahsoub, Mayssaa Moharram, Omayma Sadek, Nadjet Rezki, Mohamed Reda Aouad, Mohamed El-Taher Ibrahim Badawy, El Sayed Helmy El Ashry
LETTERS IN DRUG DESIGN & DISCOVERY
(2019)
Review
Biochemistry & Molecular Biology
Mahmoud Balbaa, Marwa El-Zeftawy, Shaymaa A. Abdulmalek
Summary: The study of diabetes mellitus patterns reveals important facts such as oxidative stress, inflammation, and cellular death. Lack of drug therapies for DM emphasizes the crucial need for discovering and developing novel therapeutics. The increasing use of medicinal plants as alternative and natural cures for diabetes highlights the importance of examining the effectiveness of these plants in managing the disease.
Article
Multidisciplinary Sciences
Shaymaa Abdulmalek, Asmaa Eldala, Doaa Awad, Mahmoud Balbaa
Summary: In this study, CurNPs and ZnONPs were found to be effective therapeutic adjuvants against T2DM complications, delaying progression by activating AKT pathway and down-regulating MAPK pathway. The findings suggest the potential application of nanoparticles with low toxicity in T2DM treatment.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Shaymaa Abdulmalek, Mayada Nasef, Doaa Awad, Mahmoud Balbaa
Summary: The study demonstrates that CurNP and ZnONP have the potential to improve hippocampal structure and function in T2DM-induced rats, alleviating neuronal damage and inflammation.
Article
Urology & Nephrology
Sarah Fawwaz, Mahmoud Balbaa, Hana Fakhoury, Jamila Borjac, Rajaa Fakhoury
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2017)
Letter
Endocrinology & Metabolism
Mahmoud Balbaa, Marwa El-Zeftawy, Nabil Taha, Abdel-Wahab Mandour
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2017)
Article
Parasitology
M. Balbaa, R. Ibrahim, D. Awad, D. A. Ghareeb, N. Abdel-Monem
TROPICAL BIOMEDICINE
(2016)