Gene therapy research for kidney diseases

Transforming growth factor-β1-overexpressing mesenchymal stromal cells induced local tolerance in rat renal ischemia/reperfusion injury

(2019) Jieru Cai et al.   CYTOTHERAPY

Nephron segment-specific gene expression using AAV vectors

(2018) Laureano D. Asico et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Efficient Gene Transfer to Kidney Mesenchymal Cells Using a Synthetic Adeno-Associated Viral Vector

(2018) Yoichiro Ikeda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity

(2018) Nicole K. Paulk et al.   MOLECULAR THERAPY

Axicabtagene ciloleucel (KTE-C19), an anti-CD19 CAR T therapy for the treatment of relapsed/refractory aggressive B-cell non-Hodgkin’s lymphoma

(2018) Michael D Jain et al.   Therapeutics and Clinical Risk Management

Lentivirus-mediated knockdown of FcγRI (CD64) attenuated lupus nephritis via inhibition of NF-κB regulating NLRP3 inflammasome activation in MRL/lpr mice

(2018) Hongfeng Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

(2018) Gerard A. Rodrigues et al.   PHARMACEUTICAL RESEARCH

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

(2018) Stephanie Vairy et al.   Drug Design Development and Therapy

Transparenchymal Renal Pelvis Injection of Recombinant Adeno-Associated Virus Serotype 9 Vectors Is a Practical Approach for Gene Delivery in the Kidney

(2018) Xufeng Shen et al.   Human Gene Therapy Methods

Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway

(2018) Yi-Ming Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting gene expression to specific cells of kidney tubules in vivo, using adenoviral promoter fragments

(2017) Sumiyo Watanabe et al.   PLoS One

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

(2016) M. Richter et al.   BLOOD

Local gene therapy with indoleamine 2,3-dioxygenase protects against development of transplant vasculopathy in chronic kidney transplant dysfunction

(2016) D Vavrincova-Yaghi et al.   GENE THERAPY

Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid

(2016) Koen Vercauteren et al.   MOLECULAR THERAPY

An essential receptor for adeno-associated virus infection

(2016) S. Pillay et al.   NATURE

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

(2016) Eloah Rabello Suarez et al.   Oncotarget

Effect of Adenoviral Catalase Gene Transfer on Renal Ischemia/Reperfusion Injury in Rats

(2015) Chih-Ching Yang   CHINESE JOURNAL OF PHYSIOLOGY

Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway

(2015) LI HUANG et al.   Molecular Medicine Reports

A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules

(2015) Judit Espana-Agusti et al.   Scientific Reports

rAAV9 combined with renal vein injection is optimal for kidney-targeted gene delivery: conclusion of a comparative study

(2014) C J Rocca et al.   GENE THERAPY

Targeting of Receptor for Advanced Glycation End Products Suppresses Cyst Growth in Polycystic Kidney Disease

(2014) Eun Young Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

(2014) Kei Adachi et al.   Nature Communications

Novel Adeno-associated Viruses Derived From Pig Tissues Transduce Most Major Organs in Mice

(2014) Alexander Bello et al.   Scientific Reports

Kidney-specific expression of GFP by in-utero delivery of pseudotyped adeno-associated virus 9

(2014) Jason L Picconi et al.   Molecular Therapy-Methods & Clinical Development

An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models

(2014) Catherine Gérard et al.   Molecular Therapy-Methods & Clinical Development

Chaperone-mediated gene therapy with recombinant AAV-PPCA in a new mouse model of type I sialidosis

(2013) Erik J. Bonten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adeno-associated Virus 9 Mediated FKRP Gene Therapy Restores Functional Glycosylation of α-dystroglycan and Improves Muscle Functions

(2013) Lei Xu et al.   MOLECULAR THERAPY

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

(2013) Leszek Lisowski et al.   NATURE

Is genetic rescue of cystinosis an achievable treatment goal?

(2013) S. Cherqui   NEPHROLOGY DIALYSIS TRANSPLANTATION

Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

(2013) Wenli Zhang et al.   PLoS One

Comparison of the transduction efficiency of tyrosine-mutant adeno-associated virus serotype vectors in kidney

(2012) Yan F. Qi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes

(2012) D. K. Kim et al.   DIABETOLOGIA

Hematopoietic Stem Cell Gene Therapy for the Multisystemic Lysosomal Storage Disorder Cystinosis

(2012) Frank Harrison et al.   MOLECULAR THERAPY

Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria

(2011) Ayesha Ghayur et al.   AMERICAN JOURNAL OF PATHOLOGY

The Assembly-Activating Protein Promotes Capsid Assembly of Different Adeno-Associated Virus Serotypes

(2011) F. Sonntag et al.   JOURNAL OF VIROLOGY

Sphingosine kinase 1 protects against renal ischemia–reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation

(2011) Sang Won Park et al.   KIDNEY INTERNATIONAL

Preclinical Dose-Finding Study With a Liver-Tropic, Recombinant AAV-2/8 Vector in the Mouse Model of Galactosialidosis

(2011) Huimin Hu et al.   MOLECULAR THERAPY

Modulation of 11 -hydroxysteroid dehydrogenase 1 by  2-adrenoceptor in the ischaemia-reperfused rat kidney

(2011) A. Nakamura et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Adenovirus-mediated anti-sense ERK2 gene therapy inhibits tubular epithelial–mesenchymal transition and ameliorates renal allograft fibrosis

(2011) Zhao Ding et al.   TRANSPLANT IMMUNOLOGY

Lentiviral-Human Heme Oxygenase Targeting Endothelium Improved Vascular Function in Angiotensin II Animal Model of Hypertension

(2010) Jian Cao et al.   HUMAN GENE THERAPY

Selective intrarenal human A1 adenosine receptor overexpression reduces acute liver and kidney injury after hepatic ischemia reperfusion in mice

(2010) Sang Won Park et al.   LABORATORY INVESTIGATION

Combined Paracrine and Endocrine AAV9 mediated Expression of Hepatocyte Growth Factor for the Treatment of Renal Fibrosis

(2010) Stephanie Schievenbusch et al.   MOLECULAR THERAPY

Kidney-specific reconstitution of the A1 adenosine receptor in A1 adenosine receptor knockout mice reduces renal ischemia–reperfusion injury

(2009) Minjae Kim et al.   KIDNEY INTERNATIONAL

Protection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of  2-adrenoceptor

(2009) A. Nakamura et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model

(2009) Anurag Sharma et al.   VIROLOGY

Adeno-associated viral vector transduction of green fluorescent protein in kidney: effect of unilateral ureteric obstruction

(2008) Keiichi Ito et al.   BJU INTERNATIONAL

Self-complementary AAV Vectors; Advances and Applications

(2008) Douglas M McCarty   MOLECULAR THERAPY

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

Role of Tissue Kallikrein in Prevention and Recovery of Gentamicin-Induced Renal Injury

(2008) Grant Bledsoe et al.   TOXICOLOGICAL SCIENCES