Implication of human drug transporters to toxicokinetics and toxicity of pesticides

Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives

(2019) Laure-Alix Clerbaux et al.   ENVIRONMENT INTERNATIONAL

Induction of multidrug resistance-associated protein 3 expression by diesel exhaust particle extract in human bronchial epithelial BEAS-2B cells

(2019) Marc Le Vée et al.   TOXICOLOGY IN VITRO

Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium

(2018) Sook Wah Yee et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium

(2018) Raymond Evers et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting

(2018) Edward T. Morgan et al.   DRUG METABOLISM AND DISPOSITION

Interactions of pesticides with membrane drug transporters: implications for toxicokinetics and toxicity

(2018) Lisa Chedik et al.   Expert Opinion on Drug Metabolism & Toxicology

Small-molecule inhibitors of multidrug resistance-associated protein 1 and related processes: A historic approach and recent advances

(2018) Sven Marcel Stefan et al.   MEDICINAL RESEARCH REVIEWS

Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers

(2018) Yugo Hamada et al.   PHARMACOLOGY

In vitro to in vivo extrapolation for high throughput prioritization and decision making

(2018) Shannon M. Bell et al.   TOXICOLOGY IN VITRO

Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters

(2018) Lisa Chedik et al.   XENOBIOTICA

Food Chemicals Disrupt Human Gut Microbiota Activity And Impact Intestinal Homeostasis As Revealed By In Vitro Systems

(2018) Clémence Defois et al.   Scientific Reports

Transport of 2,4-dichloro phenoxyacetic acid by human Na+-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8)

(2018) Kazuaki Sugio et al.   Drug Metabolism and Pharmacokinetics

Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein

(2018) Elaine F. Enright et al.   MOLECULAR PHARMACEUTICS

Vectorizing agrochemicals: enhancing bioavailability via carrier‐mediated transport

(2018) Hanxiang Wu et al.   PEST MANAGEMENT SCIENCE

Effects of environmental pollutants on gut microbiota

(2017) Yuanxiang Jin et al.   ENVIRONMENTAL POLLUTION

Concentrations of organochlorine pesticides in pooled human serum by age and gender

(2017) Aleysha Thomas et al.   ENVIRONMENTAL RESEARCH

Implicating ABC Transporters in Insecticide Resistance: Research Strategies and a Decision Framework

(2017) Ryan C. Gott et al.   JOURNAL OF ECONOMIC ENTOMOLOGY

The impact of pesticides on oxidative stress level in human organism and their activity as an endocrine disruptor

(2017) Agata Jabłońska-Trypuć et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES

The Organic Anion–Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers

(2017) Markus Keiser et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Microbiome facilitated pest resistance: potential problems and uses

(2017) Jonathan Gressel   PEST MANAGEMENT SCIENCE

Insights Into a Possible Influence on Gut Microbiota and Intestinal Barrier Function During Chronic Exposure of Mice to Imazalil

(2017) Cuiyuan Jin et al.   TOXICOLOGICAL SCIENCES

In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans

(2017) Lisa Chedik et al.   International Journal of Environmental Research and Public Health

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin

(2017) Lisa Chedik et al.   PLoS One

The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues

(2016) Jiaqiang Xu et al.   CHEMOSPHERE

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice

(2016) Takuya Kuno et al.   MOLECULAR PHARMACEUTICS

Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure

(2016) S. C. T. Nicklisch et al.   Science Advances

Nature and uses of fluorescent dyes for drug transporter studies

(2015) Olivier Fardel et al.   Expert Opinion on Drug Metabolism & Toxicology

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

(2014) Dennis Smith et al.   MOLECULAR PHARMACEUTICS

MDR1 Transporter Protects Against Paraquat-Induced Toxicity in Human and Mouse Proximal Tubule Cells

(2014) Xia Wen et al.   TOXICOLOGICAL SCIENCES

The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism

(2013) Béatrice B. Roques et al.   BIOCHEMICAL PHARMACOLOGY

Disposition of fipronil in rats

(2013) J.P. Cravedi et al.   CHEMOSPHERE

Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium

(2013) K M Hillgren et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulation of Hepatic Drug Transporter Activity and Expression by Organochlorine Pesticides

(2013) Simon Bucher et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications

(2013) David E. Smith et al.   MOLECULAR ASPECTS OF MEDICINE

Lack of P-Glycoprotein-Mediated Efflux and the Potential Involvement of an Influx Transport Process Contributing to the Intestinal Uptake of Deltamethrin, cis-Permethrin, and trans-Permethrin

(2013) Jason Zastre et al.   TOXICOLOGICAL SCIENCES

Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells

(2013) Marc Le Vee et al.   TOXICOLOGY IN VITRO

Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake

(2012) Min-Koo Choi et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants

(2012) Michele La Merrill et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Approach to Improve Compound Recovery in a High-Throughput Caco-2 Permeability Assay Supported by Liquid Chromatography–Tandem Mass Spectrometry

(2012) Xianmei Cai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of human cytochrome P450 induction by pesticides

(2012) Khaled Abass et al.   TOXICOLOGY

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

(2012) Sébastien Anthérieu et al.   TOXICOLOGY IN VITRO

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

ABC Multidrug Transporters: Target for Modulation of Drug Pharmacokinetics and Drug-Drug Interactions

(2011) Beatrice Marquez et al.   CURRENT DRUG TARGETS

Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics

(2011) Olivier Fardel et al.   Expert Opinion on Drug Metabolism & Toxicology

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression

(2010) Shuhua Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals

(2010) Daniel M. Rotroff et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Aryl Hydrocarbon Receptor Is a Transcriptional Activator of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) K. P. Tan et al.   MOLECULAR PHARMACOLOGY

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Drug transporters in the human blood-placental barrier

(2009) Kirsi Vähäkangas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines

(2009) Olivier Fardel et al.   Expert Opinion on Drug Metabolism & Toxicology

MDR1 variants and risk of Parkinson disease

(2009) Katja Zschiedrich et al.   JOURNAL OF NEUROLOGY

The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay

(2009) Leslie Z. Benet   MOLECULAR PHARMACEUTICS

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function

(2009) Ying Chen et al.   PHARMACOGENOMICS JOURNAL

Toxicogenomic effects common to triazole antifungals and conserved between rats and humans

(2009) Amber K. Goetz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interaction of pesticides with p-glycoprotein and other ABC proteins: A survey of the possible importance to insecticide, herbicide and fungicide resistance

(2007) D.S. Buss et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY