Intestinal organoids in infants and children

Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning

(2018) Marit Navis et al.   EMBO REPORTS

Human Milk Oligosaccharides Increase Mucin Expression in Experimental Necrotizing Enterocolitis

(2018) Richard You Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Neonatal intestinal organoids as an ex vivo approach to study early intestinal epithelial disorders

(2018) Bo Li et al.   PEDIATRIC SURGERY INTERNATIONAL

Long-term outcomes of pediatric intestinal failure

(2017) Brenna S. Fullerton et al.   Seminars in Pediatric Surgery

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine

(2017) Christopher R. Schlieve et al.   Stem Cell Reports

A whole new ball game: Stem cell-derived epithelia in the study of host–microbe interactions

(2016) Jhansi L. Leslie et al.   ANAEROBE

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Modeling human disease using organotypic cultures

(2016) Pawel J Schweiger et al.   CURRENT OPINION IN CELL BIOLOGY

In vitropatterning of pluripotent stem cell-derived intestine recapitulatesin vivohuman development

(2016) Yu-Hwai Tsai et al.   DEVELOPMENT

Organoids from adult liver and pancreas: Stem cell biology and biomedical utility

(2016) Christopher J. Hindley et al.   DEVELOPMENTAL BIOLOGY

Gastrointestinal organoids: How they gut it out

(2016) Sebastian R. Merker et al.   DEVELOPMENTAL BIOLOGY

hPSC-derived lung and intestinal organoids as models of human fetal tissue

(2016) Megan Aurora et al.   DEVELOPMENTAL BIOLOGY

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

Organoid Models of Human Gastrointestinal Development and Disease

(2016) Priya H. Dedhia et al.   GASTROENTEROLOGY

Fetal liver cell-containing hybrid organoids improve cell viability and albumin production upon transplantation

(2016) Jingjia Ye et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

(2016) Faranak Fattahi et al.   NATURE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Human and Murine Tissue-Engineered Colon Exhibit Diverse Neuronal Subtypes and Can Be Populated by Enteric Nervous System Progenitor Cells When Donor Colon Is Aganglionic

(2016) Minna M. Wieck et al.   TISSUE ENGINEERING PART A

Development of an Advanced Primary HumanIn VitroModel of the Small Intestine

(2016) Matthias Schweinlin et al.   TISSUE ENGINEERING PART C-METHODS

Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche

(2016) Agnieszka Pastuła et al.   Stem Cells International

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xLMutant Gene

(2015) Yasuhito Nagamoto et al.   CELL TRANSPLANTATION

Assessment and outcome of children with intestinal failure referred for intestinal transplantation

(2015) S. Ganousse-Mazeron et al.   CLINICAL NUTRITION

Recent advances in cystic fibrosis

(2015) Carlos E. Milla et al.   CURRENT OPINION IN PEDIATRICS

The future of CFTR modulating therapies for cystic fibrosis

(2015) Jane C. Davies   CURRENT OPINION IN PULMONARY MEDICINE

Generating human intestinal tissues from pluripotent stem cells to study development and disease

(2015) K. L. Sinagoga et al.   EMBO JOURNAL

Hybrid organoids consisting of extracellular matrix gel particles and hepatocytes for transplantation

(2015) Jingjia Ye et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes

(2015) Akihiro Asai et al.   Nature Reviews Gastroenterology & Hepatology

Targeted therapies to improve CFTR function in cystic fibrosis

(2015) Malcolm Brodlie et al.   Genome Medicine

Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids

(2015) S. R. Finkbeiner et al.   Biology Open

Cystic Fibrosis

(2015)   Nature Reviews Disease Primers

Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming

(2014) Atsushi Miyajima et al.   Cell Stem Cell

How to make an intestine

(2014) J. M. Wells et al.   DEVELOPMENT

Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon

(2014) Masayoshi Fukuda et al.   GENES & DEVELOPMENT

Ex vivo culture of the intestinal epithelium: strategies and applications

(2014) Marc Leushacke et al.   GUT

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

Type I Collagen as an Extracellular Matrix for the In Vitro Growth of Human Small Intestinal Epithelium

(2014) Ziyad Jabaji et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Short bowel syndrome in children: Surgical and medical perspectives

(2014) Riccardo Coletta et al.   Seminars in Pediatric Surgery

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

(2013) Robert P. Fordham et al.   Cell Stem Cell

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Hirschsprung disease

(2013) Jacob C. Langer   CURRENT OPINION IN PEDIATRICS

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

Hepatic stem cell niches

(2013) Claus Kordes et al.   JOURNAL OF CLINICAL INVESTIGATION

Human tissue-engineered small intestine forms from postnatal progenitor cells

(2013) Daniel E. Levin et al.   JOURNAL OF PEDIATRIC SURGERY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Tissue engineering: A promising therapeutic approach to necrotizing enterocolitis

(2013) Christa N. Grant et al.   Seminars in Pediatric Surgery

Use of Collagen Gel as an Alternative Extracellular Matrix for the In Vitro and In Vivo Growth of Murine Small Intestinal Epithelium

(2013) Ziyad Jabaji et al.   TISSUE ENGINEERING PART C-METHODS

Highly Efficient Differentiation of Functional Hepatocytes From Human Induced Pluripotent Stem Cells

(2013) Xiaocui Ma et al.   Stem Cells Translational Medicine

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Self-formation of layered neural structures in three-dimensional culture of ES cells

(2012) Mototsugu Eiraku et al.   CURRENT OPINION IN NEUROBIOLOGY

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Tissue Engineering of the Intestine in a Murine Model

(2012) Erik R. Barthel et al.   Jove-Journal of Visualized Experiments

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Efficient generation of functional hepatocyte-like cells from human fetal hepatic progenitor cells in vitro

(2011) Weitao Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Intestinal lineage commitment of embryonic stem cells

(2010) Li Cao et al.   DIFFERENTIATION

Risk Factors for Intestinal Failure in Infants with Necrotizing Enterocolitis: A Glaser Pediatric Research Network Study

(2010) Debora Duro et al.   JOURNAL OF PEDIATRICS

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin

(2009) Andrea Haegebarth et al.   AMERICAN JOURNAL OF PATHOLOGY

The stem cells of small intestinal crypts: where are they?

(2009) C. S. Potten et al.   CELL PROLIFERATION

Stem Cells and Liver Regeneration

(2009) Andrew W. Duncan et al.   GASTROENTEROLOGY

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Short bowel syndrome: epidemiology and etiology

(2009) Paul W. Wales et al.   Seminars in Pediatric Surgery

The hepatic stem cell niche: Identification by label-retaining cell assay

(2008) Reiichiro Kuwahara et al.   HEPATOLOGY

The stem cell niche of human livers: Symmetry between development and regeneration

(2008) Lili Zhang et al.   HEPATOLOGY