Article
Oncology
Mohamed Abdelaal, Pamela J. Mosher, Abha Gupta, Breffni Hannon, Christine Cameron, Malka Berman, Rahim Moineddin, Jonathan Avery, Laura Mitchell, Madeline Li, Camilla Zimmermann, Ahmed Al-Awamer
Summary: Adolescents and young adults with cancer often experience high levels of distress and lack effective palliative care services. Establishing a specialized integrated palliative care and psychiatry clinic has shown promising results in improving symptom scores and end-of-life planning.
Article
Pediatrics
Liwei L. Hua
Summary: Pediatricians are often the first healthcare providers to encounter adolescents and young adults presenting with psychotic symptoms, and they play a critical role in identifying, evaluating, collaborating with specialists, and referring patients. Premature diagnosis should be avoided, and other contributing factors such as co-occurring substance abuse or trauma should be considered to optimize outcomes. This clinical report provides information on psychotic and psychotic-like symptoms in pediatric patients, as well as etiology, risk factors, and recommendations for pediatricians.
Article
Medicine, General & Internal
Sumit Gupta, Qing Li, Alisha Kassam, Adam Rapoport, Kimberley Widger, Karine Chalifour, Nancy N. Baxter, Paul C. Nathan, Natalie G. Coburn, Rinku Sutradhar
Summary: Adolescents and young adults (AYAs) with cancer often experience significant symptom burden, and specialty palliative care (SPC) is important for improving symptom management. However, SPC is often not involved or involved late in their treatment.
Article
Cell Biology
Jun Ah Lee, Jiwon Lim, Hye Young Jin, Meerim Park, Hyeon Jin Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Young-Joo Won
Summary: The study compared the clinical features and survival rates of osteosarcoma in adolescents and young adults (AYA) with other age groups. It found that AYA had the highest male-to-female ratio, with most tumors located in extremities. The treatment mainly consisted of local treatment and systemic chemotherapy, and the 5-year overall survival rate of AYA was closer to that of children.
Article
Oncology
Takatoshi Hirayama, Satoru Ikezawa, Ryo Okubo, Tomoko Mizuta, Shintaro Iwata, Tatsuya Suzuki
Summary: The actual state of mental health care use and related factors in adolescent and young adult (AYA) patients with cancer in Japan remains unclear. This retrospective study examined the mental health care use among AYA patients with cancer and identified socio-demographic and related factors associated with its use. The findings may contribute to early mental health intervention for AYA patients with cancer.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Multidisciplinary Sciences
Nupur Mittal, Aniket Saha, Viswatej Avutu, Varun Monga, David R. Freyer, Michael Roth
Summary: Enrollment of adolescent and young adult (AYA) in cancer clinical trials (CCT) is not optimal, with various barriers and facilitators identified. Improving coordination between pediatric and medical oncology, providing supportive research infrastructure, and having advocates may help increase AYA enrollment in clinical trials.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jennifer W. Mack, Colin Cernik, Hajime Uno, Lanfang Xu, Cecile A. Laurent, Lauren Fisher, Nancy Cannizzaro, Julie Munneke, Robert M. Cooper, Joshua R. Lakin, Corey M. Schwartz, Mallory Casperson, Andrea Altschuler, Lori Wiener, Lawrence Kushi, Chun R. Chao
Summary: This study aimed to characterize the prevalence and timing of conversations about goals of care and advance care planning among adolescents and young adults (AYAs) with cancer at the end of life, and to analyze the relationship between such conversations and end-of-life care measures.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura C. Hart, Joseph Sirrianni, Steve Rust, Christopher Hanks
Summary: This study describes the patient features associated with timely transfer to adult health care for autistic individuals.
Article
Pediatrics
Rachel H. Alinsky, Scott E. Hadland, Joanna Quigley, Stephen W. Patrick
Summary: This article introduces the guidance recommendations of the American Academy of Pediatrics (AAP) on the terminology used by pediatricians, media, policymakers, and government agencies regarding substance use. The recommendations emphasize the importance of medically accurate, person-first, and nonstigmatizing language in promoting the health of children and adolescents.
Article
Pediatrics
Mark L. Hudak
Summary: Timely access to appropriate health care from the prenatal period onward is crucial for optimizing the health of children and facilitating their transition into adulthood. Legislation passed in 1967 established a standard for early and periodic screening, diagnostic, and treatment services for children enrolled in Medicaid.
Review
Oncology
Atsushi Makimoto
Summary: Due to their rarity, there is limited understanding of rhabdomyosarcomas (RMS) in adolescents and young adults (AYA), resulting in poor treatment outcomes. This review aims to integrate new developments with existing evidence to explore factors and potential solutions in RMS in AYA.
Article
Oncology
Michael Roth, Melissa Beauchemin, Justine M. Kahn, Archie Bleyer
Summary: This study finds that Black adolescent and young adult (AYA) patients were less likely to enroll in NCI-sponsored CTTs compared to Black children from 2000 to 2015. Enrollment of Black AYA males decreased with increasing age, highlighting disparities in CTT enrollment among this specific population.
Article
Immunology
Lise Lund Berven, Joel Selvakumar, Lise Havdal, Tonje Stiansen-Sonerud, Gunnar Einvik, Truls Michael Leegaard, Trygve Tjade, Annika E. Michelsen, Tom Eirik Mollnes, Vegard Bruun Bratholm Wyller
Summary: Mild and subacute COVID-19 in young people are associated with inflammatory enhancement but normal pulmonary function. Clinical symptoms are associated with age and female sex, but not with inflammatory and pulmonary function markers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Kenneth M. Carlson, Suzanne K. Berman, Jonathan Price
Summary: Managed care arrangements are a method of healthcare delivery that, when well-designed and implemented, can improve utilization of services, access to quality care, and medication availability. They support the Quadruple Aim of reducing costs, improving population health, enhancing patient and provider experiences. The American Academy of Pediatrics encourages the use of key principles in designing managed care arrangements to improve pediatric healthcare effectiveness.
Article
Endocrinology & Metabolism
Kelsey B. Eitel, Alissa J. Roberts, Ralph D'Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker
Summary: This study examined the association between diabetes stigma and HbA1c, treatment plan, and acute and chronic complications in adolescents and young adults with type 1 or type 2 diabetes. The results showed that diabetes stigma was associated with clinical factors and had an impact on acute and chronic complications in these patients. Therefore, addressing diabetes stigma is important in providing comprehensive diabetes care.
Review
Oncology
Rebecca H. Johnson, Carey K. Anders, Jennifer K. Litton, Kathryn J. Ruddy, Archie Bleyer
PEDIATRIC BLOOD & CANCER
(2018)
Article
Oncology
Morgan Atkinson, Andrew Murnane, Thomas Goddard, Cathy Pendergrast, Paul Rogers, Rebecca Manudhane, Michael Osborn
Summary: This study aimed to investigate the effects of a structured 10-week exercise intervention on cardiorespiratory fitness, fatigue, and quality of life in adolescents and young adults who have recently completed cancer treatment. The exercise group showed significant improvement in VO2peak at 10 weeks compared to controls, with no significant differences in fatigue or total quality of life scores between groups. The plateau in VO2peak at six months suggests the potential benefit of a maintenance exercise program.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Pandora Patterson, Kimberley R. Allison, Helen Bibby, Kate Thompson, Jeremy Lewin, Taia Briggs, Rick Walker, Michael Osborn, Meg Plaster, Allan Hayward, Roslyn Henney, Shannyn George, Dominic Keuskamp, Antoinette Anazodo
Summary: Adolescents and young adults diagnosed with cancer face unique medical and psychosocial challenges, which require tailored and comprehensive care. The Australian Youth Cancer Services have been providing developmentally appropriate care since 2011, focusing on clinical trial participation, oncofertility, psychosocial care, and survivorship. National data collection and monitoring have facilitated improvements in the coordination and accountability of quality youth cancer care.
Review
Oncology
Elizabeth J. Cathcart-Rake, Kathryn J. Ruddy, Archie Bleyer, Rebecca H. Johnson
Summary: The incidence of invasive breast cancer has increased among women under 42 in the United States, leading to more aggressive subtypes and advanced disease challenges. Early genetic testing and multidisciplinary treatment including chemotherapy with adjunctive ovarian function suppression and personalized cancer therapy are crucial for improving patient survival.
JCO ONCOLOGY PRACTICE
(2021)
Article
Oncology
Rebecca L. Jacobsen, Catherine Fiona Macpherson, Bethann Mangel Pflugeisen, Rebecca H. Johnson
Summary: The study found that AYAs treated at academic centers are more likely to be offered clinical trials and be aware of supportive services, while those treated at academic centers are more satisfied with support, communication, and overall treatment. Respondents treated at academic centers were more likely to receive information relevant to their age group and reported higher overall satisfaction with their healthcare team's knowledge of AYAs.
JCO ONCOLOGY PRACTICE
(2021)
Review
Hematology
David T. O. Yeung, Michael P. Osborn, Deborah L. White
Summary: This review summarizes the genomic pathology of B-ALL at diagnosis, including mutations detectable by traditional methods and advanced molecular techniques. These studies not only help with prognosis and diagnosis, but also provide opportunities for targeted therapies.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Joanna E. Fardell, Claire E. Wakefield, Richard De Abreu Lourenco, Christina Signorelli, Maria McCarthy, Jordana McLoone, Michael Osborn, Melissa Gabriel, Antoinette Anazodo, Frank Alvaro, Liane Lockwood, Thomas Walwyn, Jane Skeen, Ramon Tillemans, Richard J. Cohn
Summary: This study investigates the HRQoL of young childhood cancer survivors and their parents, finding that parents report lower HRQoL for their children compared to population norms. Factors influencing child HRQoL include late effects and non-surgical treatments. While parents' average HRQoL is high, a subset report clinically meaningful differences from perfect health, with more anxiety/depression issues than the general population.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Ursula M. Sansom-Daly, Claire E. Wakefield, Christina Signorelli, Mark W. Donoghoe, Antoinette Anazodo, Susan M. Sawyer, Michael Osborn, Rosalie Viney, Nicholas Daniell, Kate Faasse, Richard J. Cohn
Summary: Adolescent and young adult cancer survivors face significant physical/mental health late effects following cancer treatment, which can be minimized through tailored healthcare use. A cross-sectional study found that cancer survivors reported greater use of medical and mental health services, particularly females, those diagnosed with brain/solid tumors, and those more recently finished treatment. Further research is needed to determine if the healthcare accessed by these survivors is appropriate and meets their needs.
Article
Hematology
Matthew Greenwood, Toby Trahair, Rosemary Sutton, Michael Osborn, John Kwan, Sally Mapp, Rebecca Howman, Antoinette Anazodo, Brenton Wylie, James D'Rozario, Mark Hertzberg, Ian Irving, David Yeung, Luke Coyle, Amanda Jager, Dan Engeler, Nicola Venn, Chris Frampton, Andrew H. Wei, Kenneth Bradstock, Luciano Dalla-Pozza
Summary: The ALL06 study aimed to evaluate if patients aged 15 to 39 could receive pediatric ALL regimen. The results showed that this therapy was safe and feasible in AYA patients, with similar ability to complete induction/consolidation therapy as children. The study revealed that BMI >30 kg/m(2) and day 79 MRD positivity were associated with poorer disease-free survival and overall survival rates.
Article
Oncology
Susan L. Heatley, Elyse C. Page, Laura N. Eadie, Barbara J. McClure, Jacqueline Rehn, David T. Yeung, Michael Osborn, Tamas Revesz, Maria Kirby, Deborah L. White
Summary: Children with neurofibromatosis are at higher risk of developing certain types of leukemia, but rarely develop B-cell acute lymphoblastic leukemia (B-ALL). A study identified a new mutation in a relapsed/refractory Ph-like B-ALL patient with neurofibromatosis, which resulted in cytokine independence and increased RAS signaling, indicating leukemic transformation. Furthermore, these cells showed sensitivity to MEK inhibitors. The findings suggest a potential precision medicine target for neurofibromatosis patients with B-ALL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Psychology, Multidisciplinary
Pandora Patterson, Fiona E. J. McDonald, Kimberley R. Allison, Helen Bibby, Michael Osborn, Karen Matthews, Ursula M. Sansom-Daly, Kate Thompson, Meg Plaster, Antoinette Anazodo
Summary: The study demonstrates that the AYA-POST is a suitable tool for psychosocial screening of AYAs with cancer, facilitating the identification of distress and unique concerns in this population and valuable in triaging and tailoring care for young cancer patients. Participants' responses show high levels of satisfaction with the tool, indicating its appropriateness, practicability, and acceptability, as well as its role in facilitating communication about psychosocial needs and prompt referrals. Ratings of clinical utility did not differ significantly between AYA and HCP groups, suggesting consistency in perceptions of the tool's effectiveness across different stakeholders.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Genetics & Heredity
Laura N. Eadie, Jacqueline A. Rehn, James Breen, Michael P. Osborn, Sophie Jessop, Charlotte E. J. Downes, Susan L. Heatley, Barbara J. McClure, David T. Yeung, Tamas Revesz, Benjamin Saxon, Deborah L. White
Summary: Chromosomal rearrangements involving the KMT2A gene are common in acute lymphoblastic leukemia (ALL), particularly in infants less than 1 year old. KMT2A-rearranged ALL (KMT2Ar ALL) has a poor prognosis and often co-occurs with other chromosomal abnormalities, including disruption of the IKZF1 gene. This study reports a case of aggressive infant KMT2Ar ALL with rare IKZF1 gene fusions, and highlights the genomic complexity of this disease with the identification of novel gene fusions IKZF1::TUT1 and KDM2A::IKZF1.
Article
Oncology
Jacob J. Henderson, Anirban Das, Daniel A. Morgenstern, Sumedha Sudhaman, Vanessa Bianchi, Jill Chung, Logine Negm, Melissa Edwards, David E. Kram, Michael Osborn, Cynthia Hawkins, Eric Bouffet, Yoon-Jae Cho, Uri Tabori
JCO PRECISION ONCOLOGY
(2022)