Article
Oncology
Morgan Atkinson, Angela Tully, Carol A. A. Maher, Christopher Innes-Wong, Ray N. N. Russo, Michael P. P. Osborn
Summary: Robot-based training aims to enhance rehabilitation through the use of robotic orthotics. This study assessed the safety, feasibility, and efficacy of rehabilitation robotics in children and AYAs during or after cancer treatment. The results suggest that robot-based rehabilitation is safe and feasible, with significant beneficial effects on functional and patient-reported outcomes.
Article
Medicine, General & Internal
Alexandru-Dan Costache, Mihai Roca, Cezar Honceriu, Irina-Iuliana Costache, Maria-Magdalena Leon-Constantin, Ovidiu Mitu, Radu-Stefan Miftode, Alexandra Mastaleru, Dan Iliescu-Halitchi, Codruta-Olimpiada Halitchi-Iliescu, Adriana Ion, Stefania-Teodora Duca, Delia-Melania Popa, Beatrice Abalasei, Veronica Mocanu, Florin Mitu
Summary: Constant and intense physical activity can cause physiological adaptive changes in the human body, but it can also trigger adverse events. This study aimed to assess the combined use of cardiopulmonary exercise testing (CPET) and cardiac biomarkers in young professional athletes. The results showed significant correlations between CPET parameters and changes in Myo, CK-MB, and D-dimers. This suggests the potential of using CPET and biomarkers to evaluate professional athletes, and further research is encouraged.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Megan Morand, Michael Roth, Susan K. Peterson, Erica M. Bednar, Aarti Ramdaney, J. Andrew Livingston, Angela Yarbrough, Jessica Corredor
Summary: The study found that AYA cancer patients have similar motivational factors to pursue genetic counseling and testing, such as learning about the availability of genetic counseling services and concern about the impact of hereditary syndromes on family members. However, the younger age of diagnosis may alter how these factors affect decision-making.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Brooke Cherven, Amani Sampson, Sharon L. Bober, Kristin Bingen, Natasha Frederick, David R. Freyer, Gwendolyn P. Quinn
Summary: This study summarizes the literature on sexual function among adolescent and young adult cancer survivors, finding that they experience a burden of sexual dysfunction and interventions are needed to support sexual health and psychosexual adjustment. Collaboration between organizations is necessary to advance assessment of sexual dysfunction and test interventions to improve sexual health among this population.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Obstetrics & Gynecology
Chelsea Anderson, Victoria Fitz, Allison Deal, Darios Getahun, Marilyn L. Kwan, Jennifer E. Mersereau, Lawrence H. Kushi, Chun R. Chao, Hazel B. Nichols
Summary: This study examines the association between demographic and cancer-related characteristics and factors such as fertility discussion and fertility preservation use with attempting pregnancy after adolescent and young adult cancer. The use of fertility preservation strategies was found to be significantly associated with attempting pregnancy after cancer.
FERTILITY AND STERILITY
(2023)
Article
Cardiac & Cardiovascular Systems
Yaoshan Dun, Thomas P. Olson, Cui Li, Ling Qiu, Siqian Fu, Zeng Cao, Jeffrey W. Ripley-Gonzalez, Baiyang You, Qiuxia Li, Lihua Deng, Qingfang Li, Suixin Liu
Summary: This study provides reference values and predictive equations of CPX variables for the Chinese adult population, showing good predictive accuracy in predicting CPX variables. The predictive equations derived from this study are more appropriate for interpreting the response to maximal ramp incremental cycle ergometry in the Chinese population.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Oncology
Silvie H. M. Janssen, Winette T. A. van der Graaf, Daniel J. van der Meer, Eveliene Manten-Horst, Olga Husson
Summary: Adolescent and young adult (AYA) cancer patients, aged 15-39 years old, face unique challenges in their disease trajectory. Although the number of AYA cancer survivors has increased, they are at risk of long-term and late effects. Research efforts are needed to inform survivorship care for this growing population.
Article
Transplantation
Eva Pella, Afroditi Boutou, Aristi Boulmpou, Christodoulos E. Papadopoulos, Aikaterini Papagianni, Pantelis Sarafidis
Summary: Chronic kidney disease (CKD), especially end-stage kidney disease (ESKD), leads to increased risks of cardiovascular events and mortality. Exercise intolerance and reduced cardiovascular reserve are common in CKD patients. Cardiopulmonary exercise testing (CPET) is a non-invasive technique that evaluates cardiovascular, pulmonary, neuropsychological, and metabolic function during exercise, serving as the gold standard for identifying exercise limitations. Despite being widely used in other medical fields, CPET is not frequently utilized in everyday practice for CKD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
Eric Adjei Boakye, Katherine M. Polednik, Teresa L. Deshields, Arun Sharma, Yamile Molina, Lidia Schapira, Justin M. Barnes, Nosayaba Osazuwa-Peters
Summary: This study examined emotional distress in cancer survivors diagnosed as adolescents or young adults compared to survivors diagnosed as middle/older adults and the general population without a history of cancer. The findings showed that emotional distress was more prevalent among young adult cancer survivors than middle/older adult survivors. However, there was no difference in emotional distress between young adult cancer survivors and the general population without cancer.
ANNALS OF EPIDEMIOLOGY
(2022)
Review
Oncology
Maxime Caru, Ariane Levesque, Pooja Rao, Smita Dandekar, Christopher Terry, Valerie Brown, Lisa McGregor, Kathryn Schmitz
Summary: This scoping review summarizes previous studies on physical activity interventions in AYA cancer survivors, indicating that such interventions are feasible and acceptable. The interventions mainly focused on individualized and aerobic activities. However, the current evidence in this area is limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Raheel Rizwan, Kimberlee Gauvreau, Cheryl Vinograd, Jessica M. Yamada, Christina Mangano, Andrea K. Ng, Mark E. Alexander, Ming Hui Chen
Summary: The study found that cardiorespiratory fitness in adult survivors of HL treated with mediastinal radiation therapy progressively declines, with women developing abnormalities earlier than men. Abnormal cardiorespiratory fitness is associated with an increased risk of cardiovascular events.
JACC: CARDIOONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Jayeon Kim, Brian W. Whitcomb, Brian Kwan, David Zava, Patrick M. Sluss, Andrew Dietz, Ksenya Shliakhtsitsava, Sally A. D. Romero, Loki Natarajan, H. Irene Su
Summary: There was no association found between psychosocial stress and ovarian function in adolescent and young adult cancer survivors.
HUMAN REPRODUCTION
(2021)
Review
Oncology
Mary Jane Lim-Fat, Maria Macdonald, Sarah Lapointe, Seth Andrew Climans, Chantel Cacciotti, Manik Chahal, Sebastien Perreault, Derek S. Tsang, Andrew Gao, Stephen Yip, Julia Keith, Julie Bennett, Vijay Ramaswamy, Jay Detsky, Uri Tabori, Sunit Das, Cynthia Hawkins
Summary: The 2021 World Health Organization classification of CNS tumors includes molecular signatures with histology and emphasizes the differences between pediatric and adult-type CNS tumors. This study aims to propose a comprehensive approach to molecular testing for adolescent and young adult (AYA) patients across this spectrum, in order to improve their diagnosis and care.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Anke Smits, Claire-Marie Agius, Dominic Blake, Christine Ang, Ali Kucukmetin, Maaike van Ham, Johanna M. A. Pijnenborg, Joanne Knight, Stuart Rundle
Summary: This study aimed to assess the value of cardiopulmonary exercise testing (CPET) in predicting surgical complications in ovarian cancer surgery. The results showed that patients with a raised VE/VCO2 during CPET experienced more surgical complications. However, there was no relationship found with other outcomes such as hospital stay, readmission, and resectability of disease.
Article
Oncology
Claire Munsie, Jay Ebert, David Joske, Timothy Ackland
Summary: Exercise intervention has shown superior improvements in strength and global quality of life in adolescent and young adult (AYA) cancer patients undergoing treatment. Regardless of group allocation, enrollment in the exercise study appears to mitigate the expected decline in AYA patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Pediatrics
T. Goddard, S. Sonnappa
Summary: CPET is a non-invasive, reproducible method for assessing cardiovascular, ventilatory, and metabolic responses to exercise, used to determine exercise capacity and personalized interventions in children. EID can be caused by various factors, requiring different treatments for each cause.
PAEDIATRIC RESPIRATORY REVIEWS
(2021)
Article
Oncology
David Mizrahi, Andrew Murnane, Sharni Quinn, Jessica Crowe, Simon Rosenbaum, Diana Adams, Morgan Atkinson
Summary: The study found a high awareness among oncology professionals about the importance of exercise for cancer survivors and a majority support referring patients to exercise professionals. While fitness levels and physical activity did not impact referral habits, understanding evidence-based exercise guidelines can still lead to improved patient outcomes in cancer care.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Andrew Murnane, Nicole Kiss, Steve F. Fraser, Jeremy Lewin
Summary: In this study, adolescent and young adult cancer survivors from a single Australian institution, on average 5 years post treatment, exhibited better health behaviors compared to Australian normative data, but still below recommended guidelines. However, they continue to experience issues with fatigue and reduced health-related quality of life, especially in those not meeting the physical activity guidelines.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Pandora Patterson, Kimberley R. Allison, Helen Bibby, Kate Thompson, Jeremy Lewin, Taia Briggs, Rick Walker, Michael Osborn, Meg Plaster, Allan Hayward, Roslyn Henney, Shannyn George, Dominic Keuskamp, Antoinette Anazodo
Summary: Adolescents and young adults diagnosed with cancer face unique medical and psychosocial challenges, which require tailored and comprehensive care. The Australian Youth Cancer Services have been providing developmentally appropriate care since 2011, focusing on clinical trial participation, oncofertility, psychosocial care, and survivorship. National data collection and monitoring have facilitated improvements in the coordination and accountability of quality youth cancer care.
Review
Hematology
David T. O. Yeung, Michael P. Osborn, Deborah L. White
Summary: This review summarizes the genomic pathology of B-ALL at diagnosis, including mutations detectable by traditional methods and advanced molecular techniques. These studies not only help with prognosis and diagnosis, but also provide opportunities for targeted therapies.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Anel van Zyl, Paul C. Rogers, Mariana Kruger
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2021)
Article
Oncology
Susan L. Heatley, Elyse C. Page, Laura N. Eadie, Barbara J. McClure, Jacqueline Rehn, David T. Yeung, Michael Osborn, Tamas Revesz, Maria Kirby, Deborah L. White
Summary: Children with neurofibromatosis are at higher risk of developing certain types of leukemia, but rarely develop B-cell acute lymphoblastic leukemia (B-ALL). A study identified a new mutation in a relapsed/refractory Ph-like B-ALL patient with neurofibromatosis, which resulted in cytokine independence and increased RAS signaling, indicating leukemic transformation. Furthermore, these cells showed sensitivity to MEK inhibitors. The findings suggest a potential precision medicine target for neurofibromatosis patients with B-ALL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Psychology, Multidisciplinary
Pandora Patterson, Fiona E. J. McDonald, Kimberley R. Allison, Helen Bibby, Michael Osborn, Karen Matthews, Ursula M. Sansom-Daly, Kate Thompson, Meg Plaster, Antoinette Anazodo
Summary: The study demonstrates that the AYA-POST is a suitable tool for psychosocial screening of AYAs with cancer, facilitating the identification of distress and unique concerns in this population and valuable in triaging and tailoring care for young cancer patients. Participants' responses show high levels of satisfaction with the tool, indicating its appropriateness, practicability, and acceptability, as well as its role in facilitating communication about psychosocial needs and prompt referrals. Ratings of clinical utility did not differ significantly between AYA and HCP groups, suggesting consistency in perceptions of the tool's effectiveness across different stakeholders.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Anel Van Zyl, Mariana Kruger, Sandile Ndlovu, Sue-Ann Meehan, Paul C. Rogers
Summary: A cohort study was conducted on a group of childhood cancer survivors in South Africa to investigate their psychological distress levels. The study found that the use of different case rules based on the GSI T scores (>=50, >=57, and >=63) identified varying proportions of survivors with psychological distress.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Genetics & Heredity
Laura N. Eadie, Jacqueline A. Rehn, James Breen, Michael P. Osborn, Sophie Jessop, Charlotte E. J. Downes, Susan L. Heatley, Barbara J. McClure, David T. Yeung, Tamas Revesz, Benjamin Saxon, Deborah L. White
Summary: Chromosomal rearrangements involving the KMT2A gene are common in acute lymphoblastic leukemia (ALL), particularly in infants less than 1 year old. KMT2A-rearranged ALL (KMT2Ar ALL) has a poor prognosis and often co-occurs with other chromosomal abnormalities, including disruption of the IKZF1 gene. This study reports a case of aggressive infant KMT2Ar ALL with rare IKZF1 gene fusions, and highlights the genomic complexity of this disease with the identification of novel gene fusions IKZF1::TUT1 and KDM2A::IKZF1.
Article
Oncology
Judy Schoeman, Ilde-Marie Kellerman, Paul C. Rogers, Elena J. Ladas, Carl J. Lombard, Ronelle Uys, Mariana Kruger
Summary: This study investigated the prevalence of vitamin and iron deficiencies among pediatric cancer patients in South Africa. The research found that nearly half of the patients had iron deficiency, while a third had deficiencies in Vitamins A, D, or folate. Associations were observed between moderate acute malnutrition and low levels of Vitamins A, B12, and folate, as well as between Vitamin D deficiency and wasting. The study highlights the need for micronutrient assessment at diagnosis to ensure optimal nutritional support.
PEDIATRIC HEMATOLOGY AND ONCOLOGY
(2023)
Article
Oncology
Jacob J. Henderson, Anirban Das, Daniel A. Morgenstern, Sumedha Sudhaman, Vanessa Bianchi, Jill Chung, Logine Negm, Melissa Edwards, David E. Kram, Michael Osborn, Cynthia Hawkins, Eric Bouffet, Yoon-Jae Cho, Uri Tabori
JCO PRECISION ONCOLOGY
(2022)