Multi-Targeting by β-Elemene and Its Anticancer Properties: A Good Choice for Oncotherapy and Radiochemotherapy Sensitization

Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

(2018) Willemien J. van Driel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase

(2017) Yi Zhang et al.   Molecular Medicine Reports

Beta-elemene treatment is associated with improved outcomes of patients with esophageal squamous cell carcinoma

(2017) Zhiwei Chang et al.   SURGICAL ONCOLOGY-OXFORD

Anticancer effects of β-elemene with hyperthermia in lung cancer cells

(2017) Zhibing Wu et al.   Experimental and Therapeutic Medicine

A Review of the Symptomatic Management of Malignant Gliomas in Adults

(2017) Umang Shah et al.   Journal of the National Comprehensive Cancer Network

Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells

(2017) JingJing Wu et al.   Scientific Reports

Comparative efficacy of whole-brain radiotherapy with and without elemene liposomes in patients with multiple brain metastases from non-small-cell lung carcinoma

(2016) Y.N. Sun et al.   Current Oncology

β-Elemene enhances the efficacy of gefitinib on glioblastoma multiforme cells through the inhibition of the EGFR signaling pathway

(2016) Lin Mu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Gastric cancer

(2016) Eric Van Cutsem et al.   LANCET

Nasopharyngeal carcinoma

(2016) Melvin L K Chua et al.   LANCET

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

(2016) Eswar Shankar et al.   SEMINARS IN CANCER BIOLOGY

β-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression

(2015) Zhaoyang Hu et al.   ANTI-CANCER DRUGS

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

β-Elemene Reverses Chemoresistance of Breast Cancer Cells by Reducing Resistance Transmission via Exosomes

(2015) Jun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The effect of elemene on lung adenocarcinoma A549 cell radiosensitivity and elucidation of its mechanism

(2015) K Zou et al.   Clinics

International Variations and Trends in Renal Cell Carcinoma Incidence and Mortality

(2015) Ariana Znaor et al.   EUROPEAN UROLOGY

β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1

(2015) ShunYu Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective

(2015) Anne W.M. Lee et al.   JOURNAL OF CLINICAL ONCOLOGY

Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules

(2015) Tingzhun Zhu et al.   Journal of Translational Medicine

Global survival patterns: potential for cancer control

(2015) Linda C Harlan et al.   LANCET

Inhibition of tumor growth by β-elemene through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model

(2015) Hong Shi et al.   MELANOMA RESEARCH

Acute Lymphoblastic Leukemia in Children

(2015) Stephen P. Hunger et al.   NEW ENGLAND JOURNAL OF MEDICINE

β-elemene enhances both radiosensitivity and chemosensitivity of glioblastoma cells through the inhibition of the ATM signaling pathway

(2015) SIWEI LIU et al.   ONCOLOGY REPORTS

β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation

(2015) Jun-Song Liu   WORLD JOURNAL OF GASTROENTEROLOGY

Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives

(2014) Jichao Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

�-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression

(2014) Jun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

LncRNA profile study reveals a three-lncRNA signature associated with the survival of patients with oesophageal squamous cell carcinoma

(2014) Jiagen Li et al.   GUT

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

β-elemene inhibits stemness, promotes differentiation and impairs chemoresistance to temozolomide in glioblastoma stem-like cells

(2014) TING-ZHUN ZHU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

RETRACTED: β-Elemene against human lung cancer via up-regulation of P53 protein expression to promote the release of exosome

(2014) Jianying Li et al.   LUNG CANCER

β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9

(2014) Hong Shi et al.   MELANOMA RESEARCH

β-Elemene inhibits proliferation through crosstalk between glia maturation factor β and extracellular signal-regulated kinase 1/2 and impairs drug resistance to temozolomide in glioblastoma cells

(2014) TING-ZHUN ZHU et al.   Molecular Medicine Reports

Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis

(2014) Hai-Wei Xie et al.   TUMOR BIOLOGY

β-elemene reverses the drug resistance of A549/DDP lung cancer cells by activating intracellular redox system, decreasing mitochondrial membrane potential and P-glycoprotein expression, and inducing apoptosis

(2014) Chengcai Yao et al.   Thoracic Cancer

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells

(2013) Zhi-Jun Dai et al.   Cancer Cell International

Elemene, One Ingredient of a Chinese Herb, Against Malignant Tumors: A Literature-based Meta-analysis

(2013) Hong-Bin Xu et al.   CANCER INVESTIGATION

New Perspectives of Curcumin in Cancer Prevention

(2013) W. Park et al.   Cancer Prevention Research

Upregulation of the Long Non-coding RNA PlncRNA-1 Promotes Esophageal Squamous Carcinoma Cell Proliferation and Correlates with Advanced Clinical Stage

(2013) Chun-Mei Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

The Role of E3 Ubiquitin Ligase Cbl Proteins in β-Elemene Reversing Multi-Drug Resistance of Human Gastric Adenocarcinoma Cells

(2013) Ye Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers

(2013) Feng Shi et al.   International Journal of Nanomedicine

β-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK

(2013) QUENTIN Q. LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs

(2013) Q. Quentin Li et al.   MEDICAL ONCOLOGY

β-elemene decreases cell invasion by upregulating E-cadherin expression in MCF-7 human breast cancer cells

(2013) XIAN ZHANG et al.   ONCOLOGY REPORTS

Beta-Elemene Blocks Epithelial-Mesenchymal Transition in Human Breast Cancer Cell Line MCF-7 through Smad3-Mediated Down-Regulation of Nuclear Transcription Factors

(2013) Xian Zhang et al.   PLoS One

β-Elemene Induces Apoptosis in Human Renal-cell Carcinoma 786-0 Cells through Inhibition of MAPK/ERK and PI3K/Akt/mTOR Signalling Pathways

(2012) Yun-Hong Zhan et al.   Asian Pacific Journal of Cancer Prevention

Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor α (ERα) re-expression

(2012) Bin Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

TGF-β signalling and its role in cancer progression and metastasis

(2012) Yvette Drabsch et al.   CANCER AND METASTASIS REVIEWS

Down-Regulation of Survivin and Hypoxia-Inducible Factor-1α by β-elemene Enhances the Radiosensitivity of Lung Adenocarcinoma Xenograft

(2012) Guoquan Li et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Enhancement of cisplatin-induced apoptosis by β-elemene in resistant human ovarian cancer cells

(2012) Qingdi Quentin Li et al.   MEDICAL ONCOLOGY

β-elemene inhibits the proliferation of T24 bladder carcinoma cells through upregulation of the expression of Smad4

(2012) XINSHENG LU et al.   Molecular Medicine Reports

β-elemene acts as an antitumor factor and downregulates the expression of survivin, Bcl-xL and Mta-1

(2012) Luoyan Yang   Molecular Medicine Reports

Potential role of β-elemene on histone H1 in the H22 ascites hepatoma cell line

(2012) Hong Zhang   Molecular Medicine Reports

Reversion of Multidrug Resistance in a Chemoresistant Human Breast Cancer Cell Line by ß-Elemene

(2012) Hong-Bin Xu et al.   PHARMACOLOGY

β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis

(2011) Jing Liu et al.   BMC CANCER

Lysosomal membrane permeabilization contributes to elemene emulsion-induced apoptosis in A549 cells

(2011) Long-Jie Li et al.   FREE RADICAL RESEARCH

Esophageal Cancer: A Critical Evaluation of Systemic Second-Line Therapy

(2011) Christiane Maria Rosina Thallinger et al.   JOURNAL OF CLINICAL ONCOLOGY

Amelioration of Experimental Autoimmune Encephalomyelitis by β-elemene Treatment is Associated with Th17 and Treg Cell Balance

(2011) Rongwei Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells

(2011) Jing Liu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cbl-regulated Akt and ERK signals are involved in β-elemene-induced cell apoptosis in lung cancer cells

(2011) Xuejun Hu   Molecular Medicine Reports

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

β-elemene inhibits proliferation of human glioblastoma cells through the activation of glia maturation factor β and induces sensitization to cisplatin

(2011) Yinghui Xu   ONCOLOGY REPORTS

Anti-cancer natural products isolated from chinese medicinal herbs

(2011) Wen Tan et al.   Chinese Medicine

Does ocular treatment of uveal melanoma influence survival?

(2010) B Damato   BRITISH JOURNAL OF CANCER

Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma

(2010) E. G. Van Meir et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis

(2010) Wenxing Chen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Preparation, characterization and relative bioavailability of oral elemene o/w microemulsion

(2010) Zhaowu Zeng   International Journal of Nanomedicine

ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6

(2010) Xu   INTERNATIONAL JOURNAL OF ONCOLOGY

Phase II Evaluation of Pemetrexed in the Treatment of Recurrent or Persistent Platinum-Resistant Ovarian or Primary Peritoneal Carcinoma: A Study of the Gynecologic Oncology Group

(2009) David S. Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

An investigation of the ability of elemene to pass through the blood-brain barrier and its effect on brain carcinomas

(2009) Xue Shen Wu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Adjuvant radiation therapy for high-risk nodal metastases from cutaneous melanoma

(2009) B Ashleigh Guadagnolo et al.   LANCET ONCOLOGY

Synthesis and in vitro anti-proliferative activity of β-elemene monosubstituted derivatives in HeLa cells mediated through arrest of cell cycle at the G1 phase

(2008) Yanhong Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-tumor effect of β-elemene in glioblastoma cells depends on p38 MAPK activation

(2008) Yi-Qun Yao et al.   CANCER LETTERS

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

Systemic therapy for metastatic malignant melanoma - from deeply disappointing to bright future?

(2008) Paul Lorigan et al.   EXPERIMENTAL DERMATOLOGY

Malignant Gliomas in Adults

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Chylothorax with Elemene

(2008) Q. Jianjun et al.   THORACIC AND CARDIOVASCULAR SURGEON