Article
Cell Biology
Liguo Xie, Guodong Zhu, Junjie Shang, Xuemei Chen, Chunting Zhang, Xiuling Ji, Qi Zhang, Yunlin Wei
Summary: Lovastatin, a secondary metabolite isolated from fungi, has been shown to have various effects such as reducing blood lipid concentration, anti-inflammatory, anti-cancer, and neuroprotective effects. Studies have demonstrated its significant inhibitory effect on cancer cell viability in various cancers, as well as its ability to increase the sensitivity of some cancer cells to chemotherapeutic drugs, enhancing the therapeutic effect.
CELLULAR SIGNALLING
(2021)
Review
Chemistry, Medicinal
Eslam R. El-Sawy, Gilbert Kirsch
Summary: Marine products, particularly aplysinopsins, are valuable sources of biologically active compounds. Aplysinopsins, derived from various marine organisms such as sponges, corals, sea anemone, and nudibranch, have been isolated from different geographic regions including the Pacific, Indonesia, Caribbean, and Mediterranean. This review provides an up-to-date overview of the sources, synthesis, and biological activities of aplysinopsin derivatives.
Article
Agronomy
Zhe Chen, Xiaojing Li, Xianli Xia
Summary: The study found a significant positive correlation between socioeconomic status and the adoption rate of biological control technology, with farmers of various socioeconomic status showing significant differences in adoption rate. Exploratory learning and exploitative learning under dual learning had a significant mediating effect on farmers' socioeconomic status in relation to BCT adoption.
PEST MANAGEMENT SCIENCE
(2022)
Article
Food Science & Technology
Mercedes Taroncher, Pilar Vila-Donat, Josefa Tolosa, Maria Jose Ruiz, Yelko Rodriguez-Carrasco
Summary: Plant nutraceuticals are gaining international attention for their potential health benefits, but safety concerns arise due to the possibility of containing residues from pesticides and other contaminants during production.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Review
Chemistry, Applied
Sunan Wang, Yi Qiu, Fan Zhu
Summary: Kiwifruit is a commercially important fruit crop with various dietary nutrients and functional ingredients. It exhibits multiple health benefits, but evidence of its impact on preventing and treating chronic diseases is not yet clear. Future research should focus on sustainable utilization of kiwifruit resources, purification of bioactive compounds, and the physiological mechanisms and clinical significance of kiwifruits.
Review
Plant Sciences
Alexandra Cristina Tocai (Motoc), Tijana Kokeric, Septimiu Tripon, Lucian Barbu-Tudoran, Ana Barjaktarevic, Snezana Cupara, Simona Ioana Vicas
Summary: Plants have been cultivated for their nutritional and medicinal properties throughout history. The genus Sanguisorba, which includes Sanguisorba officinalis L. and Sanguisorba minor Scop., has a long history of medicinal use. Our research focuses on gathering extensive information on Sanguisorba minor, including its history, taxonomy, habitat, distribution, bioactive components, and biological activities. This study also provides electron microscopy observations of plant parts and information on potential pests or beneficial insects. The goal is to provide a solid foundation for future research on Sanguisorba minor Scop.
Review
Biochemistry & Molecular Biology
Altijana Hromic-Jahjefendic, Abas Sezer, Alaa A. A. Aljabali, Angel Serrano-Aroca, Murtaza M. Tambuwala, Vladimir N. Uversky, Elrashdy M. Redwan, Debmalya Barh, Kenneth Lundstrom
Summary: COVID-19 vaccines have been widely used to reduce the incidence and disease severity of COVID-19. Recent concerns have been raised about a possible association between COVID-19 vaccines and myocarditis. Myocarditis can be caused by infections, immune reactions, or toxic exposure. The incidence rate of myocarditis after vaccination is lower than that after SARS-CoV-2 infection, and it is more common in adolescent males following mRNA vaccination.
Review
Oncology
Reisya R. R. Riantiningtyas, Florence Carrouel, Amandine Bruyas, Wender L. P. Bredie, Camille Kwiecien, Agnes Giboreau, Anestis Dougkas
Summary: The present review highlights the changes in food perception among head and neck cancer patients, including taste, texture, temperature, and other oral sensations. These changes not only have physiological importance but also convey psychological and psychosocial values. Comprehensive assessment of patients' food perception can lead to personalized dietary interventions to improve their eating experience and quality of life. More studies on oral somatosensory perception with larger sample sizes and standardized assessment methods are needed to fully understand its impact on eating behavior and quality of life.
Review
Biochemistry & Molecular Biology
Drishti Ghelani, Simon Alesi, Aya Mousa
Summary: The role of vitamin D in modulating the immune system in the context of COVID-19 has been discussed in research, with evidence suggesting that low levels of vitamin D may lead to poor prognosis but supplementation can help mitigate these effects, although its benefits remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Felix Recillas-Targa
Summary: Cancer is a complex disease caused by genetic and epigenetic alterations in cell division control. Understanding the origin and evolution of tumorigenic processes through cancer genomics and epigenomics has advanced our knowledge of the molecular causes of cancer. The interplay between genetic and epigenetic mutations, as well as their interaction with environmental factors such as the microbiome, influences cellular metabolism and proliferation rates, leading to tumorigenesis. Integrating and improving our understanding of these processes can enhance cancer diagnosis, prognosis, and genetic and epigenetic therapies.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Weronika Majchrzak, Ilona Motyl, Krzysztof Smigielski
Summary: The cosmetics industry is searching for innovative ingredients with higher bioactivity and bioavailability. Bioferments are extracted from natural raw materials through fermentation with appropriate strains of microorganisms, mainly plant-based. They have a broad range of applications in areas like skin whitening, antioxidant properties, anti-aging, hydration, and anti-allergic effects. Fermentation increases the biochemical and physiological activity of the substrate, making fermented raw materials more compatible compared to unfermented ones.
Review
Chemistry, Multidisciplinary
Audrey Nsamela, Aidee Itandehui Garcia Zintzun, Thomas D. Montenegro-Johnson, Juliane Simmchen
Summary: This article reviews the recent development of biomimicking behaviors in active colloids, focusing on the swimming mechanisms and mechanosensory response parameters of both biological and artificial microswimmers. The comparison of these two classes of microswimmers provides analogies in terms of fuel dependence, interaction with boundaries, and stimuli-induced motion.
Review
Immunology
Alessio Facciola, Giuseppa Visalli, Antonio Lagana, Angela Di Pietro
Summary: Vaccines are crucial in preventing infectious diseases, and adjuvants play a key role in enhancing vaccine efficacy. Recent research has focused on developing new compounds with effective adjuvant properties and improved safety. Modern technologies like nanotechnologies and molecular biology have improved vaccine production by enhancing both antigen and adjuvant components. Microparticles, emulsions, and immune stimulators are being explored for their potential in vaccine production. While vaccine adjuvants may have potential side effects, the significant value of vaccines cannot be denied, particularly in managing future pandemics. Research into adjuvants could play a leading role in producing more effective vaccines.
Review
Oncology
Itaru Hashimoto, Takashi Oshima
Summary: This review highlights the biological and clinical significance of claudin (CLDN) expression in gastric cancer (GC), with a focus on CLDN18.2 and clinical trials centered around it. Abnormal expression of CLDNs, particularly CLDN18, is observed in GC. CLDNs are potential targets for antibody drugs in GC treatment.
Review
Biochemistry & Molecular Biology
Sophie Negrel, Jean Michel Brunel
Summary: Polyamine conjugates have been highlighted in various biological and medicinal fields, with recent focus on natural polyamines and advancements in understanding fundamental mechanisms and therapeutic applications of polyamine derivatives.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Renata Bortolus, Francesca Filippini, Francesca Chiaffarino, Silvia Udali, Marianna Rinaldi, Giorgio Gandini, Martina Montagnana, Giuseppe Lippi, Oliviero Olivieri, Fabio Parazzini, Simonetta Friso
Summary: This study investigated the iron status of healthy blood donors in Italy and found that a large proportion of the subjects had adequate plasma iron and ferritin concentrations. There was a relationship between folate-related genetic polymorphisms and iron metabolism, which warrants further investigation.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Medical Laboratory Technology
Gian Luca Salvagno, Brandon M. Henry, Giulio Bongiovanni, Simone De Nitto, Laura Pighi, Giuseppe Lippi
Summary: This proof of concept study demonstrates the potential feasibility of using rapid diagnostic tests to gather information on viral load in patients with acute SARS-CoV-2 infection.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Wayne J. Dimech, Giuseppe A. Vincini, Mario Plebani, Giuseppe Lippi, James H. Nichols, Oswald Sonntag
Summary: As testing for infectious diseases evolves, the methods for controlling these assays need to change as well. Traditional quality control methods used in clinical chemistry are not suitable for infectious disease serology due to the many differences between the two. This paper outlines these differences and provides recommendations for quality control in infectious disease serology.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Letter
Otorhinolaryngology
Riccardo Nocini, Giuseppe Lippi, Camilla Mattiuzzi
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Letter
Medicine, General & Internal
Camilla Mattiuzzi, Giuseppe Lippi
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Letter
Hematology
Giuseppe Lippi, Valeria Perilli
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Editorial Material
Hematology
Emmanuel J. Favaloro, Leonardo Pasalic, Giuseppe Lippi
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Medicine, General & Internal
Laura Pighi, Brandon M. Henry, Simone De Nitto, Gianluca Gianfilippi, Gian Luca Salvagno, Giuseppe Lippi
Summary: This study presents a real-world assessment of the clinical performance of the COVID-VIRO ALL IN device. Although its diagnostic performance does not exactly match that of the manufacturer, it has a high negative predictive value in high viral load samples, allowing for rapid identification of highly contagious individuals.
Editorial Material
Medicine, General & Internal
Giuseppe Lippi, Brandon M. Henry
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Giuseppe Lippi, Brandon Michael Henry, Fabian Sanchis-Gomar
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Giuseppe Lippi, Brandon M. Henry
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Immunology
Kin Israel Notarte, Jesus Alfonso Catahay, Princess Juneire Peligro, Jacqueline Veronica Velasco, Abbygail Therese Ver, Jonathan Jaime Guerrero, Jin Liu, Giuseppe Lippi, Stefanie W. Benoit, Brandon Michael Henry, Cesar Fernandez-de-las-Penas
Summary: This systematic review aimed to assess the humoral response of hemodialysis patients post-mRNA SARS-CoV-2 vaccination. A total of nine studies met the inclusion criteria, and the results showed that hemodialysis patients developed lower antibody levels compared to the control group. These findings imply the need for robust vaccination strategies to address waning immune responses in vulnerable populations.
Letter
Medical Laboratory Technology
Simone De Nitto, Laura Pighi, Gian Luca Salvagno, Giuseppe Lippi
ADVANCES IN LABORATORY MEDICINE-AVANCES EN MEDICINA DE LABORATORIO
(2023)
Letter
Medicine, General & Internal
Giuseppe Lippi, Fabian Sanchis-Gomar, Brandon M. Henry
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Oncology
Brandon Michael Henry, Giuseppe Lippi, Ameen Nasser, Patryk Ostrowski
Summary: The study analyzed phase IV clinical trials in oncology from ClinicalTrials.gov registry data. It examined trials conducted from January 2013 to December 2022 for key characteristics such as outcomes, interventions, sample sizes, study design, cancer types, and regions. The analysis included 368 phase IV oncology studies. Findings showed that 50% of the studies examined safety and efficacy, 43.5% reported only efficacy outcomes, and 6.5% described only safety outcomes. Only 16.9% of the studies were powered to detect rare adverse events. Targeted therapies accounted for the majority (53.5%) of the studies, with breast and hematological cancers being the most investigated types. Limited sample sizes in phase IV oncology studies hindered the detection of rare adverse events, emphasizing the need for additional education and participation in spontaneous reporting processes.
